Metal based neurodegenerative diseases—From molecular mechanisms to therapeutic strategies

Protein aggregation and neurodegenerative disease

Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120

Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)

Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,357

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

Uchida, K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00014-6 · Cited by 1,164

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

Sian, J., Dexter, D. T., Lees, A. J., Daniel, S., Agid, Y., Javoy‐Agid, F., Jenner, P., & Marsden, C. D. (1994) · Annals of Neurology · doi:10.1002/ana.410360305 · Cited by 1,161

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897

Metallochaperones, an Intracellular Shuttle Service for Metal Ions

O'Halloran, T. V., & Culotta, V. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000006200 · Cited by 806

Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

Curtain, C. C., Ali, F. E. A., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K. T., Barrow, C. J., Masters, C. L., Bush, A. I., & Barnham, K. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100175200 · Cited by 658

Involvement of oxidative stress in Alzheimer disease

Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611

A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease

Alam, Z. I., Daniel, S. E., Lees, A. J., Marsden, D. C., Jenner, P. G., & Halliwell, B. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031326.x · Cited by 547

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

Sayre, L. M., Perry, G. L., Harris, P. L. R., Liu, Y. A., Schubert, K. A., & Smith, M. A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740270.x · Cited by 543

Cholinergic modulation of microglial activation by α7 nicotinic receptors

Shytle, R. D., Mori, T., Townsend, K. P., Vendrame, M., Sun, N., Zeng, J., Ehrhart, J. C., Silver, A. A., Sanberg, P. R., & Tan, J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02347.x · Cited by 537

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

Zecca, L., Stroppolo, A., Gatti, A., Tampellini, D., Toscani, M., Gallorini, M., Giaveri, G., Arosio, P., Santambrogio, P., Fariello, R. G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403495101 · Cited by 495

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

Gabbita, S. P., Lovell, M. A., & Markesbery, W. R. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052034.x · Cited by 479

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed Central · Cited by 425

Movement of zinc and its functional significance in the brain

Takeda, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00044-8 · Cited by 422

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

Gaeta, A., & Hider, R. C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706416 · Cited by 411

Redox-active iron mediates amyloid-β toxicity

Rottkamp, C. A., Raina, A. K., Zhu, X., Gaier, E., Bush, A. I., Atwood, C., Chevion, M., Perry, G. L., & Smith, M. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00494-9 · Cited by 379

Synaptically released zinc: Physiological functions and pathological effects

Frederickson, C. J., & Bush, A. I. (2001) · BioMetals · doi:10.1023/a:1012934207456 · Cited by 360

The Relevance of Iron in the Pathogenesis of Parkinson's Disease

Götz, M. E., Double, K. L., Gerlach, M., Youdim, M. B. H., & RIEDERERE, P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.017 · Cited by 343

Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions

Loeffler, D. A., Connor, J. R., Juneau, P. L., Snyder, B. S., Kanaley, L., DeMaggio, A. J., Nguyen, H., Brickman, C. M., & LeWitt, P. A. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020710.x · Cited by 334

Metals and Alzheimer's disease

Adlard, P. A., & Bush, A. I. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-102-303 · Cited by 324

Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease

Castellani, R. J., Smith, M. A., Richey, G. L., & Perry, G. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00729-9 · Cited by 315

Glutathione‐related enzymes in brain in Parkinson's disease

Sian, J., Dexter, D. T., Lees, A. J., Daniel, S. E., Jenner, P. G., & MARSDEN, C. D. (1994) · Annals of Neurology · doi:10.1002/ana.410360306 · Cited by 296

Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

Zecca, L., Zucca, F. A., Wilms, H., & Sulzer, D. L. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.009 · Cited by 265

Iron deposits in multiple sclerosis and Alzheimer's disease brains

LeVine, S. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00470-8 · Cited by 258

Decreased ferritin levels in brain in Parkinson's disease

Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08814.x · Cited by 258

Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences

Crichton, R. R. (2001) · Cited by 244

Heme oxygenase expression in human central nervous system disorders

Schipper, H. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.015 · Cited by 237

Amyloid-beta precursor protein processing in neurodegeneration

Wilquet, V., & Strooper, B. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.08.001 · Cited by 236

Metal Ions Differentially Influence the Aggregation and Deposition of Alzheimer's β-Amyloid on a Solid Template

Ha, C., Ryu, J., & Park, C. B. (2007) · Biochemistry · doi:10.1021/bi7000032 · Cited by 231

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification

Takeda, A., Smith, M. A., Ávila, J., Nunomura, A., Siedlak, S. L., Zhu, X., Perry, G. L., & Sayre, L. M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751234.x · Cited by 206

Production of Reactive Oxygen Species from Aggregating Proteins Implicated in Alzheimers Disease, Parkinsons Disease and Other Neurodegenerative Diseases

Tabner, B. S. P. B. J., Turnbull, B. S. P. S., El-Agnaf, B. S. P. O. M. A., & Allsop, B. S. P. D. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394822 · Cited by 174

Abnormal localization of iron regulatory protein in Alzheimer’s disease

Smith, M. A., Wehr, K., Harris, P. L. R., Siedlak, S. L., Connor, J. R., & Perry, G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00002-x · Cited by 162

Nanoparticle and other metal chelation therapeutics in Alzheimer disease

Liu, G., Garrett, M. R., Men, P., Zhu, X., Perry, G. L., & Smith, M. A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.06.006 · Cited by 160

Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase

Harris, F. M., Brecht, W. J., Xu, Q., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408127200 · Cited by 151

Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases

Youdim, M. B. H., Fridkin, M., & Zheng, H. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.023 · Cited by 128

The galvanization of β-amyloid in Alzheimer's disease

Bush, A. I., & Tanzi, R. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122249699 · Cited by 122

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

Moreira, P. I., Siedlak, S. L., Aliev, G., Zhu, X., Cash, A., Smith, M. A., & Perry, G. L. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0242-8 · Cited by 119

Lack of up-regulation of ferritin is associated with sustained iron regulatory protein-1 binding activity in the substantia nigra of patients with Parkinson's disease

Faucheux, B. A., Martin, M., Beaumont, C., Hunot, S., Hauw, J., Agid, Y., & Hirsch, E. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01118.x · Cited by 116

Mechanism of zinc‐induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH‐SY5Y neuroblastoma cells

An, W., Björkdahl, C., Liu, R., Cowburn, R. F., Winblad, B. G., & Pei, J.-J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02948.x · Cited by 107

Iron Deficient and Manganese Supplemented Diets Alter Metals and Transporters in the Developing Rat Brain

Garcia, S. J., Gellein, K., Syversen, T. L. M., & Aschner, M. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl139 · Cited by 102

Estrogen Decreases Zinc Transporter 3 Expression and Synaptic Vesicle Zinc Levels in Mouse Brain

Lee, J., Kim, J.-H., Hong, S. H., Lee, J. Y., Cherny, R. A., Bush, A. I., Palmiter, R. D., & Koh, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309730200 · Cited by 98

Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage alzheimer’s disease

Lovell, M. A., Smith, J. L., Xiong, S., & Markesbery, W. R. (2005) · Neurotoxicity Research · doi:10.1007/bf03033884 · Cited by 91

Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias

Magaki, S., Raghavan, R., Mueller, C., Oberg, K. C., Vinters, H. V., & Kirsch, W. M. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.077 · Cited by 77

Metal‐based Neurodegeneration

Crichton, R. R., & Ward, R. J. (2005) · Wiley eBooks · doi:10.1002/0470022574 · Cited by 73

The influence of brain acetaldehyde on oxidative status, dopamine metabolism and visual discrimination task

Heap, L., Ward, R. J., Abiaka, C., Dexter, D. T., Lawlor, M., PRATT, O. E., Thomson, A. D., Shaw, K., & Peters, T. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)00539-x · Cited by 65

Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells

Johnson, D., Bayele, H. K., Johnston, K. L., Tennant, J. P., Srai, S. K., & Sharp, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.081 · Cited by 60

Iron genes, iron load and risk of Alzheimer’s disease

Lehmann, D. J., Worwood, M., Ellis, R., Wimhurst, V. L. J., Merryweather‐Clarke, A. T., Warden, D. R., Smith, A. D., & Robson, K. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.040519 · Cited by 49

Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians

Zambenedetti, P., Bellis, G. D., Biunno, I., Musicco, M., & Zatta, P. F. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5601 · Cited by 46

Amyloid-β: a (life) preserver for the brain

Obrenovich, M. E., Joseph, J. A., Atwood, C., Perry, G. L., & Smith, M. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00038-6 · Cited by 44

Identification of a Heme-sensing Domain in Iron Regulatory Protein 2

Jeong, J., Rouault, T. A., & Levine, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407562200 · Cited by 31

Effect of chronic chloroquine administration on iron loading in the liver and reticuloendothelial system and on oxidative responses by the alveolar macrophages

Legssyer, R., Ward, R. J., Crichton, R. R., & Boelaert, J. R. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00368-2 · Cited by 26

Neurodegeneration: How Does Parkin Prevent Parkinson's Disease?

Cookson, M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00446-9 · Cited by 18

Amyloid-β Vaccination: Testing the Amyloid Hypothesis?

Lee, H., Zhu, X., Nunomura, A., Perry, G. L., & Smith, M. A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060633 · Cited by 18

Desferrioxamine for Alzheimer's disease

Flaten, T. P., Garruto, R. M., Davies, P., Weiner, M., Holleman, D. R., Goldstone, J. R., Andrews, D. F., McLachlan, D. R. C., Dalton, A. J., Kruck, T. P. A., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)90472-2 · Cited by 18

Multicenter Metal–Organic Framework‐Based Ratiometric Fluorescent Sensors

Wu, S., Min, H., Shi, W., & Cheng, P. (2019) · Advanced Materials · doi:10.1002/adma.201805871 · Cited by 715

Highly Sensitive and Selective Colorimetric and Off−On Fluorescent Chemosensor for Cu2+ in Aqueous Solution and Living Cells

Zhao, Y., Zhang, X., Han, Z., Qiao, L., Li, C., Jian, L., Shen, G., & Yu, R. (2009) · Analytical Chemistry · doi:10.1021/ac901127n · Cited by 456

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Prachayasittikul, V., Prachayasittikul, V., Prachayasittikul, S., & Ruchirawat, S. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s49763 · Cited by 461

Environmental-induced oxidative stress in neurodegenerative disorders and aging

Migliore, L., & Coppedè, F. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.09.013 · Cited by 397

Chemodosimeters: An approach for detection and estimation of biologically and medically relevant metal ions, anions and thiols

Kaur, K., Saini, R., Kumar, A., Luxami, V., Kaur, N., Singh, P., & Kumar, S. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.04.013 · Cited by 381

The transition metals copper and iron in neurodegenerative diseases

Rivera-Mancía, S., Pérez‐Neri, I., Ríos, C., Tristán-López, L. A., Rivera-Espinosa, L., & Montes, S. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.010 · Cited by 247

Metal-based neurodegeneration. From molecular mechanisms to therapeutic strategies, 2nd Edition

Crichton, R. R., & Ward, R. J. (2013) · DIAL (Catholic University of Leuven) · doi:10.1002/9781118553480 · Cited by 1

ROLA METALI W ROZWOJU CHOROBY ALZHEIMERA I PARKINSONA

Żygowska, J., & Szymańska, A. (2022) · Wiadomości Chemiczne · doi:10.53584/wiadchem.2022.1.1

Redox active metals in neurodegenerative diseases

Acevedo, K. M., Masaldan, S., Opazo, C., & Bush, A. I. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01731-9 · Cited by 102

The Relevance of Metals in the Pathophysiology of Neurodegeneration, Pathological Considerations

Jellinger, K. A. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-410502-7.00002-8 · Cited by 101