CoChat
Sign Up
Cited by 284

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

Wei, Junping, Wunderlich, Mark, Fox, Catherine, Alvarez, Sara, Cigudosa, Juan C., Wilhelm, Jamie S., Zheng, Yi, Cancelas, Jose A., Gu, Yi, Jansen, Michael, DiMartino, Jorge F., Mulloy, James C.·2008·Cancer Cell
DOI 10.1016/j.ccr.2008.04.020
Open this paper in CoChat — free account

Abstract

Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Some leukemia stem cells (LSC) were multipotent and could be lineage directed by altering either the growth factors or the recipient strain of mouse, highlighting the importance of microenvironmental cues. Other LSC were strictly lineage committed, demonstrating the heterogeneity of the stem cell compartment in MLL disease. Targeting the Rac signaling pathway by pharmacologic or genetic means resulted in rapid and specific apoptosis of MLL-AF9 cells, suggesting that the Rac signaling pathway may be a valid therapeutic target in MLL-rearranged AML.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2008.04.020

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 7 references

Research works printed but not linked: 37

  1. Armstrong, 2002, MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia, Nat. Genet., 30, 41, 10.1038/ng765 · DOI
  2. Armstrong, 2003, Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification, Cancer Cell, 3, 173, 10.1016/S1535-6108(03)00003-5 · DOI
  3. Armstrong, 2004, FLT3 mutations in childhood acute lymphoblastic leukemia, Blood, 103, 3544, 10.1182/blood-2003-07-2441 · DOI
  4. Baer, 1998, Acute myeloid leukemia with 11q23 translocations: Myelomonocytic immunophenotype by multiparameter flow cytometry, Leukemia, 12, 317, 10.1038/sj.leu.2400933 · DOI
  5. Barabe, 2007, Modeling the initiation and progression of human acute leukemia in mice, Science, 316, 600, 10.1126/science.1139851 · DOI
  6. Bullinger, 2004, Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia, N. Engl. J. Med., 350, 1605, 10.1056/NEJMoa031046 · DOI
  7. Chen, 2006, A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy, Blood, 108, 669, 10.1182/blood-2005-08-3498 · DOI
  8. Corral, 1996, An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes, Cell, 85, 853, 10.1016/S0092-8674(00)81269-6 · DOI
  9. Cozzio, 2003, Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors, Genes Dev., 17, 3029, 10.1101/gad.1143403 · DOI
  10. Cumano, 1992, Bipotential precursors of B cells and macrophages in murine fetal liver, Nature, 356, 612, 10.1038/356612a0 · DOI
  11. De Braekeleer, 2005, The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia, Anticancer Res., 25, 1931
  12. Dimartino, 1999, Mll rearrangements in haematological malignancies: Lessons from clinical and biological studies, Br. J. Haematol., 106, 614, 10.1046/j.1365-2141.1999.01439.x · DOI
  13. DiMartino, 2002, The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10, Blood, 99, 3780, 10.1182/blood.V99.10.3780 · DOI
  14. DiMartino, 2006, Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein, Leukemia, 20, 426, 10.1038/sj.leu.2404102 · DOI
  15. Ford, 1993, In utero rearrangements in the trithorax-related oncogene in infant leukaemias, Nature, 363, 358, 10.1038/363358a0 · DOI
  16. Gao, 2004, Rational design and characterization of a Rac GTPase-specific small molecule inhibitor, Proc. Natl. Acad. Sci. USA, 101, 7618, 10.1073/pnas.0307512101 · DOI · Paper page
  17. Iwasaki, 2003, GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages, Immunity, 19, 451, 10.1016/S1074-7613(03)00242-5 · DOI
  18. Iwasaki, 2006, The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages, Genes Dev., 20, 3010, 10.1101/gad.1493506 · DOI · Paper page
  19. Lacayo, 2004, Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes, Blood, 104, 2646, 10.1182/blood-2003-12-4449 · DOI
  20. Lavau, 1997, Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL, EMBO J., 16, 4226, 10.1093/emboj/16.14.4226 · DOI
  21. Montecino-Rodriguez, 2001, Bipotential B-macrophage progenitors are present in adult bone marrow, Nat. Immunol., 2, 83, 10.1038/83210 · DOI
  22. Mulloy, 2003, Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element, Blood, 102, 4369, 10.1182/blood-2003-05-1762 · DOI
  23. Ozeki, 2004, Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia, Blood, 103, 1901, 10.1182/blood-2003-06-1845 · DOI
  24. Ross, 2004, Gene expression profiling of pediatric acute myelogenous leukemia, Blood, 104, 3679, 10.1182/blood-2004-03-1154 · DOI
  25. Schoch, 2003, AML with 11q23/MLL abnormalities as defined by the WHO classification: Incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases, Blood, 102, 2395, 10.1182/blood-2003-02-0434 · DOI
  26. Secker-Walker, 1998, General report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997, Leukemia, 12, 776, 10.1038/sj.leu.2401011 · DOI
  27. So, 2003, MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice, Cancer Cell, 3, 161, 10.1016/S1535-6108(03)00019-9 · DOI
  28. So, 2003, Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias, Cancer Cell, 4, 99, 10.1016/S1535-6108(03)00188-0 · DOI
  29. Somervaille, 2006, Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia, Cancer Cell, 10, 257, 10.1016/j.ccr.2006.08.020 · DOI · Paper page
  30. Stam, 2005, Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia, Blood, 106, 2484, 10.1182/blood-2004-09-3667 · DOI
  31. Stubbs, 2007, FLT3 as a therapeutic target in childhood acute leukemia, Curr. Drug Targets, 8, 703, 10.2174/138945007780830782 · DOI
  32. Stubbs, 2008, MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: Development of a model for rapid therapeutic assessment, Leukemia, 22, 66, 10.1038/sj.leu.2404951 · DOI
  33. Warner, 2005, Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells, Leukemia, 19, 1794, 10.1038/sj.leu.2403917 · DOI
  34. Wunderlich, 2006, Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability, Blood, 108, 1690, 10.1182/blood-2005-12-012773 · DOI
  35. Xie, 2004, Stepwise reprogramming of B cells into macrophages, Cell, 117, 663, 10.1016/S0092-8674(04)00419-2 · DOI
  36. Yang, 2000, Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells, Immunity, 12, 557, 10.1016/S1074-7613(00)80207-1 · DOI · Paper page
  37. Zeisig, 2003, The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell, Oncogene, 22, 1629, 10.1038/sj.onc.1206104 · DOI

Cited by

Metadata

Authors
Wei, J., Wunderlich, M., Fox, C., Alvarez, S., Cigudosa, J. C., Wilhelm, J. S., Zheng, Y., Cancelas, J. A., Gu, Y., Jansen, M., DiMartino, J. F., & Mulloy, J. C.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2008-06
Volume
13
Issue
6
Pages
483-495
ISSN
1535-6108
DOI
10.1016/j.ccr.2008.04.020
Cited by
284
References
7
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review