Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

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1. Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?
   Markus David Siegelin · 2013 · Cancer Letters
2. HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer
   Karem A. Court, Hiroto Hatakeyama, Sherry Y. Wu, Mangala S. Lingegowda, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Lee Ju-Seog, Carlos Rinaldi, Eduardo J. Juan, Anil K. Sood et al. · 2017 · Molecular Cancer Therapeutics
3. HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
   Jacqueline H. L. Fok, Somaieh Hedayat, Lei Zhang, Lauren I. Aronson, Fabio Mirabella, Charlotte Pawlyn, Michael D. Bright, Christopher P. Wardell, Jonathan J. Keats, Emmanuel de Billy et al. · 2018 · Clinical Cancer Research
4. Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition
   Anna Budina-Kolomets, Gregor M. Balaburski, Anastasia Bondar, Neil Beeharry, Tim J. Yen, Maureen E. Murphy · 2013 · Cancer Biology & Therapy
5. The role of the cytosolic HSP70 chaperone system in diseases caused by misfolding and aberrant trafficking of ion channels
   Jason C. Young · 2014 · Disease Models & Mechanisms
6. Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells
   Chenghai Li, Kristifor Sunderic, Steven B. Nicoll, Sihong Wang · 2018 · Scientific Reports
7. Molecular biology of chronic myeloid leukemia
   Yoshiro Maru · 2012 · Cancer Science
8. Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges
   Peter W. Piper, Stefan H. Millson · 2011 · Pharmaceuticals
9. Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70
   Tony Taldone, Yanlong Kang, Hardik J. Patel, Maulik R Patel, Pallav D. Patel, Anna Rodina, Yogita Patel, Alexander Gozman, Ronnie Maharaj, Cristina Corina Clement et al. · 2014 · Journal of Medicinal Chemistry
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    Cheryl A. London, Misty D. Bear, Jennifer McCleese, Kevin P. Foley, Reji Paalangara, Takayo Inoue, Weiwen Ying, James Barsoum · 2011 · PLoS ONE
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    Xiandan Cui, Hyo‐Kyoung Choi, Young-Seok Choi, Soo‐Yeon Park, Gi‐Jun Sung, Yoo‐Hyun Lee, Jeongmin Lee, Woo Jin Jun, Kyung‐Sup Kim, Kyung‐Chul Choi et al. · 2014 · Cancer Letters
12. Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia
    Huilin Huang, Hengyou Weng, Bowen Dong, Panpan Zhao, Hui Zhou, Liang‐Hu Qu · 2017 · Scientific Reports
13. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades
    Sharan R. Srinivasan, Laura C. Cesa, Xiaokai Li, Olivier Julien, Min Zhuang, Hao Shao, Jooho Chung, Ivan P. Maillard, James A. Wells, Colin S. Duckett et al. · 2017 · Molecular Cancer Research
14. Hsp90: Still a viable target in prostate cancer
    Margaret M. Centenera, Alyssa K. Fitzpatrick, Wayne D. Tilley, Lisa M. Butler · 2012 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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    Laura O’Regan, Josephina Sampson, Mark W. Richards, Axel Knebel, Daniel Röth, Fiona E. Hood, Anne Straube, Stephen Royle, Richard W. Bayliss, Andrew M. Fry · 2015 · The Journal of Cell Biology
16. mTOR Inhibition Potentiates HSP90 Inhibitor Activity via Cessation of HSP Synthesis
    Jaime Acquaviva, Suqin He, Jim Sang, Donald Lawrence Smith, Manuel Sequeira, Chaohua Zhang, Richard C. Bates, David A. Proia · 2014 · Molecular Cancer Research
17. An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target
    Matthew K. Howe, Brittany L. Speer, Philip F. Hughes, David R. Loiselle, Subhash G. Vasudevan, Timothy Haystead · 2016 · Antiviral Research
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    Ryou‐u Takahashi, Fumitaka Takeshita, Kimi Honma, Masaya Ono, Kikuya Kato, Takahiro Ochiya · 2013 · Scientific Reports
19. Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor
    Ting Li, Xin Chen, Xiao-Yang Dai, Bin Wei, Qinjie Weng, Xiuping Chen, Defang Ouyang, Ru Yan, Zhangjian Huang, Hu‐Lin Jiang et al. · 2017 · Toxicology and Applied Pharmacology
20. Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy
    Sihan Du, Ying Liu, Yuan Yuan, Yuran Wang, Yanfang Chen, Shuai Wang, Yuhua Chi · 2022 · Frontiers in Cell and Developmental Biology
21. Tumor suppression by apoptotic and anti‐angiogenic effects of mortalin‐targeting adeno‐oncolytic virus
    Ji Young Yoo, Jihoon Ryu, Ran Gao, Tomoko Yaguchi, Sunil C. Kaul, Renu Wadhwa, Chae‐Ok Yun · 2010 · The Journal of Gene Medicine
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    Seyedeh Elham Mostafavinia, Mohsen Khorashadizadeh, Reyhane Hoshyar · 2016 · DNA and Cell Biology
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    Javiera Ríos, Álvaro Sequeida, Amelina Albornoz, Mauricio Budini · 2021 · Frontiers in Oncology
24. Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90
    Mirela Matokanović, Karmela Barišić, Jelena Filipović‐Grčić, Dušica Maysinger · 2013 · European Journal of Pharmaceutical Sciences
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    Shardule P. Shah, Sagar Lonial, Lawrence Boise · 2015 · Molecular Cancer Research
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    Anna Budina-Kolomets, Marie R. Webster, Julia I-Ju Leu, Matthew Jennis, Clemens Krepler, Anastasia Guerrini, Andrew V. Kossenkov, Wei Xu, Giorgos Constantine Karakousis, Lynn Mara Schuchter et al. · 2016 · Cancer Research
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    Lijun Zhang, Xiao Zhang, Guihong Lu, Feng Li, Weier Bao, Cui Song, Wei Wei, Guanghui Ma · 2019 · Small
28. Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiation
    Hyeon‐Ok Jin, Sung‐Eun Hong, Ji‐Young Kim, Mi‐Ri Kim, Yoon Hwan Chang, Young Joon Hong, Jinsun Lee, In‐Chul Park · 2019 · Oncology Reports
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    Aaron Carman Sarah Kishinevsky, John Koren III Wenjie Lou · 2013 · Journal of Alzheimer’s Disease & Parkinsonism
30. Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer
    Nuramalina H Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenço, Fiona F. Cahill, Yanyan Jiang, Anthony H. Kong, Anderson Joseph Ryan · 2019 · BMC Cancer
31. Targeting GRP75 Improves HSP90 Inhibitor Efficacy by Enhancing p53-Mediated Apoptosis in Hepatocellular Carcinoma
    Weiwei Guo, Lichong Yan, Ling Yang, Xiaoyu Liu, E Qiukai, Peiye Gao, Xiaofei Ye, Wen Liu, Ji Zuo · 2014 · PLoS ONE
32. The Ras Signaling Inhibitor LOX-PP Interacts with Hsp70 and c-Raf To Reduce Erk Activation and Transformed Phenotype of Breast Cancer Cells
    Seiichi Sato, Philip C. Trackman, Joni M. Mäki, Johanna Myllyharju, Kathrin H. Kirsch, Gail E. Sonenshein · 2011 · Molecular and Cellular Biology
33. Correction: Functional Analysis of Hsp70 Inhibitors
    Rainer Schlecht, Sebastian Scholz, Heike Dahmen, Ansgar A. Wegener, Christian Sirrenberg, Djordje Müsil, Joerg Bomke, Hans‐Michael Eggenweiler, Matthias P. Mayer, Bernd Bukau · 2013 · PLoS ONE
34. High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex
    Isabelle R. Taylor, Bryan M. Dunyak, Tomoko Komiyama, Hao Shao, Ran Xu, Victoria A. Assimon, Chakrapani Kalyanaraman, Jennifer N. Rauch, Matthew P. Jacobson, Erik R. P. Zuiderweg et al. · 2018 · Journal of Biological Chemistry
35. A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies
    Anna Spreafico, Jean‐Pierre Delord, Leticia De Mattos‐Arruda, Yann Bergé, Jordi Ahnert Rodon, Ewa Cottura, Philippe Lucien Bedard, Mikhail Akimov, Hong Laura Lu, Scott Pain et al. · 2015 · British Journal of Cancer
36. Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors
    Yan-qun Zeng, Ruiyuan Cao, Tianhong Zhang, Song Li, Wu Zhong · 2015 · European Journal of Medicinal Chemistry
37. Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70
    Matthew D. Cheeseman, Isaac M. Westwood, Olivier R. Barbeau, Martin Rowlands, Sarah E. Dobson, Alan M. Jones, Fiona Jeganathan, Rosemary Burke, Nadia Kadi, Paul Workman et al. · 2016 · Journal of Medicinal Chemistry
38. Relationship between HSP90a, NPC2 and L-PGDS proteins to boar semen freezability
    Julián Valencia, Germán Gómez, Walter Ricardo López, Henry Mesa, Francisco Henao · 2017 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
39. Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90
    Stefan H. Millson, Chun‐Song Chua, Stephen Mark Roe, Sigrun Polier, Svetlana E. Solovieva, Laurence H. Pearl, Tiow‐Suan Sim, Chrisostomos Prodromou, Peter W. Piper · 2011 · The FASEB Journal
40. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
    Marissa V. Powers, Melanie R. Valenti, Susana Miranda, Alison Maloney, Suzanne A. Eccles, GEORGE V. THOMAS, Paul Andrew Clarke, Paul Workman · 2013 · Oncotarget
41. Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma
    Amit J. Sabnis, Christopher J. Guerriero, Victor R. Olivas, Anin Sayana, Jonathan Shue, Jennifer Flanagan, Saurabh Asthana, Adrienne W. Paton, James C. Paton, Jason E. Gestwicki et al. · 2016 · Proceedings of the National Academy of Sciences
42. The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine
    M. Lazenby, Robert Kerrin Hills, Alan K. Burnett, Joanna Zabkiewicz · 2015 · Leukemia Research
43. Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants
    Elizabeth V. Nguyen, Margaret M. Centenera, Max V. Moldovan, Rajdeep Das, Swati Irani, Andrew D. Vincent, Howard Chan, Lisa Glen Horvath, David John Lynn, Roger J. Daly et al. · 2018 · Molecular & Cellular Proteomics
44. Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2
    Zundong Liu, Xiaolin Sang, Min Wang, Yichao Liu, Jiao Liu, Xuefei Wang, Pixu Liu, Hai-Ling Margaret Cheng · 2021 · Oncogene
45. Heat shock proteins and cancer: The FoxM1 connection
    Zahra Alimardan, Maryam Abbasi, Farshid Hasanzadeh, Mahmud Aghaei, Ghadamali Khodarahmi, Khosrow Kashfi · 2023 · Biochemical Pharmacology
46. POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim
    Chun‐Hua Wang, Shi-Xun Lu, Li-Li Liu, Yong Li, Xia Yang, Yang-Fan He, Shi-Lu Chen, Shaohang Cai, Hong Wang, Jing‐Ping Yun · 2018 · Neoplasia
47. The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth
    Daniela Brünnert, Clara Langer, Luise Zimmermann, Ralf Christian Bargou, Martin Burchardt, Manik Chatterjee, Matthias Bernhard Stope · 2019 · Journal of Cellular Biochemistry
48. Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy
    Nagaraj S. Nagathihalli, Om V. Singh, Nipun B. Merchant · 2010 · Expert Review of Proteomics
49. The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition
    Daniela Schilling, Carmen Garrido, Stephanie Elisabeth Combs, Gabriele Multhoff · 2017 · Cancer Letters
50. Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells
    Alisha R. Yallowitz, Amr M. Ghaleb, Lucas Garcia, Evguenia M. Alexandrova, Natalia D. Marchenko · 2018 · Cell Death and Disease
51. The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways
    Wonkyoung Cho, Xiongjie Jin, Junfeng Pang, Yan Wang, Nahid F. Mivechi, Demetrius Moskophidis · 2019 · Molecular and Cellular Biology
52. Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress
    Zhang, Lei, Fok, Jacqueline J.L., Mirabella, Fabio, Aronson, Lauren I., Fryer, Rosemary A., Workman, Paul, Morgan, Gareth J., Davies, Faith E. · 2013 · Cancer Letters
53. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance
    Hongwei Luo, Haitian Quan, Chengying Xie, Yongping Xu, L Fu, Liguang Lou · 2010 · Leukemia
54. Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer
    Andrew Eichholz, Roberta Ferraldeschi, Gerhardt Attard, Johann Sebastian De Bono · 2011 · Molecular and Cellular Endocrinology
55. Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors
    Håkon Reikvam, Ina Nepstad, André Sulen, Bjørn Tore Gjertsen, Kimberley Joanne Hatfield, Øystein Bruserud · 2013 · Expert Opinion on Investigational Drugs
56. Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines
    Alpa V. Patel, Swee Y. Sharp, Katelan Hall, William Lewis, Malcolm F. G. Stevens, Paul Workman, Christopher J. Moody · 2016 · Organic & Biomolecular Chemistry
57. Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment
    Damian Robert Sojka, Agnieszka Gogler‐Pigłowska, Natalia Vydra, Alexander Jorge Cortez, Piotr Teodor Filipczak, Zdzisław Krawczyk, Dorota Ścieglińska · 2019 · Scientific Reports
58. Protein chaperones: a composition of matter review (2008 – 2013)
    Tony Taldone, Hardik Patel, Alexander Bolaender, Maulik R Patel, Gabriela Chiosis · 2014 · Expert Opinion on Therapeutic Patents
59. Increased expression of a set of genes enriched in oxygen binding function discloses a predisposition of breast cancer bone metastases to generate metastasis spread in multiple organs
    Mattia Capulli, Adriano Angelucci, Keltouma Driouch, Teresa Garcia, Philippe Clément-Lacroix, Francesco Martella, Luca Ventura, Mauro Bologna, Stefano Flamini, Oreste Moreschini et al. · 2012 · Journal of Bone and Mineral Research
60. The expanding proteome of the molecular chaperone HSP90
    Rahul S. Samant, Paul Andrew Clarke, Paul Workman · 2012 · Cell Cycle
61. Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit
    Martin Rowlands, Craig McAndrew, Chrisostomos Prodromou, Laurence H. Pearl, Andrew Kalusa, Keith Jones, Paul Workman, Wynne Aherne · 2010 · SLAS DISCOVERY
62. Discorhabdin N, a South African Natural Compound, for Hsp72 and Hsc70 Allosteric Modulation: Combined Study of Molecular Modeling and Dynamic Residue Network Analysis
    Arnold Amusengeri, Özlem Taştan Bishop · 2019 · Molecules
63. Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives
    Jiao Wang, Jin Chi Zhang, Zeyu Guo, Hui Ming Hua, Hongying Zhang, Yongliang Liu, Yangfu Jiang · 2023 · Phytomedicine
64. Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer
    Magdalena Zajac, Gonzalo Goméz-López, Javier J. Benitez, Beatriz Martínez–Delgado · 2010 · BMC Medical Genomics
65. Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer
    Alice H. Cavanaugh, Brendon Juengst, Kathleen M. Sheridan, John F. Danella, Heinric Williams · 2015 · Oncotarget
66. Panobinostat for the treatment of acute myelogenous leukemia
    Fortunato Morabito, Maria Teresa Voso, Stefan Hohaus, Massimo Gentile, Ernesto Vigna, Anna Grazia Recchia, Lorenzo Iovino, E. Benedetti, Francesco Lo‐Coco, Sara Galimberti · 2016 · Expert Opinion on Investigational Drugs
67. A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms
    Alan M. Jones, Isaac M. Westwood, James D. Osborne, Thomas P. Matthews, Matthew D. Cheeseman, Martin Rowlands, Fiona Jeganathan, Rosemary Burke, David Lee, Nadia Kadi et al. · 2016 · Scientific Reports
68. A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response
    Heather Armstrong, Yen Chin Koay, Swati Irani, Rajdeep Das, Zeyad D. Nassar, The Australian Prostate Cancer BioResource, Luke A. Selth, Margaret M. Centenera, Shelli R. McAlpine, Lisa M. Butler · 2016 · The Prostate
69. Stress-induced interaction between p38 MAPK and HSP70
    Xiaowei Gong, Tingting Luo, Peng Deng, Zhenxi Liu, Jiancheng Xiu, Hongqin Shi, Yong Jiang · 2012 · Biochemical and Biophysical Research Communications
70. HSP90 inhibitor AUY922 abrogates up‐regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer
    Si-Meng Chen, Chen-liang Guo, Jia‐Jie Shi, Yi‐Chao Xu, Yi Chen, Yanyan Shen, Yi Su, Jian Ding, Ling‐Hua Meng · 2014 · International Journal of Cancer
71. Engaging the Lysosome and Lysosome-Dependent Cell Death in Cancer
    Anastasia L. Berg, Ashley R. Rowson-Hodel, Madelyn R. Wheeler, Michelle Hu, Savannah R. Free, Kermit L. Carraway · 2022 · Exon Publications eBooks
72. Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies
    James E. H. Day, Swee Y. Sharp, Martin Rowlands, Wynne Aherne, Angela Hayes, Florence I. Raynaud, William Lewis, Stephen Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl et al. · 2011 · ACS Chemical Biology
73. Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition
    Lindsay E. Evans, Matthew D. Cheeseman, Norhakim Yahya, Keith Jones · 2015 · PLoS ONE
74. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells
    Daniela Schilling, Annett Kühnel, Fabian Tetzlaff, Sarah Konrad, Gabriele Multhoff · 2015 · Cancer Immunology Immunotherapy
75. Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer
    Anna Rodina, Tony Taldone, Yanlong Kang, Pallav D. Patel, John Koren, Pengrong Yan, Erica M. Gomes-DaGama, Chenghua Yang, Maulik R Patel, Liza Shrestha et al. · 2014 · ACS Chemical Biology
76. Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98
    Hao Shao, Jason E. Gestwicki · 2020 · Bioorganic & Medicinal Chemistry Letters
77. Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells
    C Kao, Angel Chao, C L Tsai, Chou-Han Lin, W C Chuang, H W Chen, Tzu-Hai Yen, T H Wang, Chyong‐Huey Lai, Hongrui Wang · 2013 · Cell Death and Disease
78. A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors
    Kyle R. Urquhart, Yinghong Zhao, Jessica A. Baker, Ye Lu, Lei Yan, Melloni N. Cook, Byron C. Jones, Kristin M. Hamre, Lu Lu · 2016 · Neurogenetics
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    Esther Katharina Schmitt, Dominic Hoepfner, Philipp Krastel · 2015 · Journal of Industrial Microbiology & Biotechnology
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    Thomas L. Prince, Andrew Ackerman, Alice H. Cavanaugh, Brielle R. Schreiter, Brendon Juengst, Chaylen Jade Andolino, John F. Danella, Mitchell I. Chernin, Heinric Williams · 2018 · Oncotarget
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    Arum R. Yoon, Renu Wadhwa, Sunil C. Kaul, Chae‐Ok Yun · 2022 · Frontiers in Cell and Developmental Biology
82. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells
    Sara Sannino, Christopher J. Guerriero, Amit J. Sabnis, Donna Beer Stolz, Callen T. Wallace, Peter Wipf, Simon C. Watkins, Trever Grant Bivona, Jeffrey L. Brodsky · 2018 · Journal of Cell Science
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    Cholpon S. Djuzenova, Christina Blassl, Konstanze Roloff, Sebastian Kuger, Astrid Katzer, Natalia Niewidok, Nadine Günther, Bülent Polat, Vladimir L. Sukhorukov, Michael P. Flentje · 2012 · Cancer Biology & Therapy
84. Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition
    Mounia Beloueche‐Babari, Vaitha Arunan, L. Elizabeth Jackson, Nina P. Perusinghe, Swee Y. Sharp, Paul Workman, Martin O. Leach · 2010 · Oncotarget
85. The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells
    Susanne Schaefer, Tina H. Svenstrup, Bárbara Guerra · 2017 · PLoS ONE
86. Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective
    Paul Workman · 2020 · Advances in experimental medicine and biology
87. Label-Free Quantitative Mass Spectrometry Reveals a Panel of Differentially Expressed Proteins in Colorectal Cancer
    Nai‐Jun Fan, Jiang-Ling Gao, Yan Liu, Wei Song, Zhan-Yang Zhang, Chunfang Gao · 2015 · BioMed Research International · Retracted
88. P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement
    Hee Joung Kim, Kye Young Lee, Young Whan Kim, Yun Jung Choi, Jungeun Lee, Chang Choi, In-jeong Baek, Jin Kyung Rho, Jae Cheol Lee · 2015 · BMC Cancer
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    Fabiola Cervantes-Gomez, Ramadevi Nimmanapalli, Varsha V. Gandhi · 2009 · Cancer Research
90. Proteome Interrogation Using Nanoprobes To Identify Targets of a Cancer-Killing Molecule
    Liwen Li, Qiu Zhang, Aifeng Liu, Xiue Li, Hongyu Zhou, Yin Liu, Bing Yan · 2011 · Journal of the American Chemical Society
91. Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules
    Seong-Hyun Park, Won-Je Kim, Hui Li, Wonil Seo, Sang-Hyun Park, Il Hwan Kim, Sang Chul Shin, Erik R. P. Zuiderweg, Eunice EunKyeong Kim, Taebo Sim et al. · 2017 · Scientific Reports
92. Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors
    Khanh T Do, Geraldine O’Sullivan Coyne, John L. Hays, Jeffrey G. Supko, Stephen V. Liu, Kristin E. Beebe, Len Neckers, Jane B. Trepel, Min-Jung Lee, Tomoko Smyth et al. · 2020 · Cancer Chemotherapy and Pharmacology
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    Sangah Lee, Jiyae Jung, Yujin Lee, Seon‐Kyu Kim, Jung‐Ae Kim, Bo‐Kyung Kim, Kyung Chan Park, Byoung‐Mog Kwon, Dong Cho Han · 2021 · Cancers
94. Suppressing the CDC 37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth
    Zhanhui Wang, Wei Wei, Chris Kin-Wai Sun, Mei‐Sze Chua, Samuel K. So · 2014 · Liver International
95. Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells
    Dong · 2009 · International Journal of Oncology
96. The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities
    Xun Fu, Huan Liu, Jiang Liu, Michael E. DiSanto, Xinhua Zhang · 2022 · Cells
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98. Effect of Boar Sperm Proteins and Quality Changes on Field Fertility
    Ilias Michos, Maria P. Tsantarliotou, C. Boscos, Georgios Tsousis, Athina Basioura, Eleni D. Tzika, Panagiotis D. Tassis, Aristotelis G. Lymberopoulos, Ioannis A. Tsakmakidis · 2021 · Animals
99. Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor
    Wei Fu, Savitha S. Sharma, Lingfei Ma, Baoky Chu, Marilyn M. Bui, Damon R. Reed, Warren Jack Pledger · 2013 · Cell Death and Disease
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     Fatima Zahra Kabbaj, Su Lu, My El Abbés Faouzi, Bouchra Meddah, Peter Proksch, Yahia Cherrah, Hans‐Josef Altenbach, Amal Hassan Aly, Ahmed Chadli, Abdessamad Debbab · 2014 · Bioorganic & Medicinal Chemistry