The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
Open accessAbstract
We report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (INPP4B) in human epithelial cells, like knockdown of PTEN, resulted in enhanced Akt activation, anchorage-independent growth, and enhanced over all motility. In xenograft experiments overexpression of INPP4B resulted in reduced tumor growth. INPP4B preferentially hydrolyzes phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) with no effect on phosphatidylinositol-3.4.5-triphosphate (PI(3,4,5)P3), suggesting that PI(3,4)P2 and PI(3,4,5)P3 may cooperate in Akt activation and cell transformation. Dual knockdown of INPP4B and PTEN resulted in cellular senescence. Finally, we find loss-of-heterozygosity (LOH) at the INPP4B locus in a majority of basal-like breast cancers as well as in a significant fraction of ovarian cancers, which correlated with lower over all patient survival, suggesting that INPP4B is a tumor suppressor.
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Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,166
Comprehensive molecular portraits of human breast tumours
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AKT/PKB Signaling: Navigating the Network
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The emerging mechanisms of isoform-specific PI3K signalling
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Cellular Senescence: Aging, Cancer, and Injury
Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00020.2018 · Cited by 1,270
Metadata
- Authors
- Gewinner, C., Wang, Z. C., Richardson, A., Teruya-Feldstein, J., Etemadmoghadam, D., Bowtell, D., Barretina, J., Lin, W. M., Rameh, L., Salmena, L., Pandolfi, P. P., & Cantley, L. C.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 16
- Issue
- 2
- Pages
- 115-125
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2012116166
- Cited by
- 461
- References
- 48
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling. https://app.cochat.ai/papers/10.1016/j.ccr.2009.06.006
- The paper
- Gewinner, C., Wang, Z. C., Richardson, A., Teruya-Feldstein, J., Etemadmoghadam, D., Bowtell, D., Barretina, J., Lin, W. M., Rameh, L., Salmena, L., Pandolfi, P. P., & Cantley, L. C. (2009). Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling. Cancer Cell. https://doi.org/10.1016/j.ccr.2009.06.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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