The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis
Open accessAbstract
SUMMARY NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to down-regulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We generated mice deficient in Nlrp12 and studied its role in inflammatory diseases such as colitis and colorectal tumorigenesis. We show that Nlrp12-deficient mice are highly susceptible to colon inflammation and tumorigenesis, which is associated with increased production of inflammatory cytokines, chemokines and tumorigenic factors. Enhanced colon inflammation and colorectal tumor development in Nlrp12-deficient mice are due to a failure to dampen NF-κB and ERK activation in macrophages. These results reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis.
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Cites
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Cited by
Garrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404
Diverging inflammasome signals in tumorigenesis and potential targeting
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Self-citationInflammasomes in carcinogenesis and anticancer immune responses
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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
Sundaram, B., Pandian, N., Mall, R., Wang, Y., Sarkar, R., Kim, H. J., Malireddi, R. K. S., Karki, R., Janke, L. J., Vogel, P., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.005 · Cited by 423
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Metadata
- Authors
- Zaki, M. H., Vogel, P., Malireddi, R. K. S., Body-Malapel, M., Anand, P. K., Bertin, J., Green, D. R., Lamkanfi, M., & Kanneganti, T.-D.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 20
- Issue
- 5
- Pages
- 649-660
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2121722333
- Cited by
- 412
- References
- 10
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zaki, M. H., Vogel, P., Malireddi, R. K. S., Body-Malapel, M., Anand, P. K., Bertin, J., Green, D. R., Lamkanfi, M., & Kanneganti, T.-D. (2011). The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.10.022
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