The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
Open accessAbstract
The differentiation of tumorigenic cancer stem cells into non-tumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functional differences between tumorigenic and non-tumorigenic cells influence response to therapy and prognosis. However, it remains uncertain whether the model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which existing assays underestimate the frequency of tumorigenic cells. In cancers with rapid genetic change, reversible changes in cell states, or biological variability among patients the stem cell model may not be readily testable.
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Citations
Cites
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“…can arise from restricted progenitors or differentiated cells as a result of mutations that ectopically activate selfrenewal mechanisms in these cells (Figure 2A) (Cozzio et al., 2003; Huntly et al., 2004; Krivtsov et al., 2006; Schüller et al., 2008; Yang et al., 2008; Zhao et al., 2010).”
BackgroundInfluential
Cited by
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
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Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
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Stem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524
Metadata
- Authors
- Magee, J. A., Piskounova, E., & Morrison, S. J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 21
- Issue
- 3
- Pages
- 283-296
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1980714336
- Cited by
- 1,101
- References
- 17
- FWCI
- 60.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Magee, J. A., Piskounova, E., & Morrison, S. J. (2012). Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty. Cancer Cell. https://doi.org/10.1016/j.ccr.2012.03.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
