Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Open accessAbstract
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.
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Exosome sheath enhanced tumor accumulation and vascular extravasation after Doxorubicin pre-loading.
“After being pre-loaded with Doxorubicin, the exosome sheath enhanced tumor accumulation and vascular extravasation.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [61]
The PSiNP system exhibits remarkable cell absorption and cytotoxicity in tumor cells.
“In addition, this system exhibits remarkable cell absorption and cytotoxicity in tumor cells [61].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [61]
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- Authors
- Yong, T., Zhang, X., Bie, N., Zhang, H., Zhang, X., Li, F., Hakeem, A., Hu, J., Gan, L., Santos, H. A., & Yang, X.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Åbo Akademi University (FI)
- University of Helsinki (FI)
- Corresponding author
- Gan, Lu
- Santos, Hélder A.
- Yang, Xiangliang
- ORCID
- Venue
- Nature Communications
- Published
- 2019-08-23
- Volume
- 10
- Issue
- 1
- Pages
- 3838-3838
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6707218
- OpenAlex
- W2969354046
- Cited by
- 806
- References
- 59
- Citations by year
- 2026: 52 · 2025: 121 · 2024: 100 · 2023: 138 · 2022: 151 · 2021: 143 · 2020: 93 · 2019: 7 · 2013: 1
- FWCI
- 27.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Åbo Akademi University Research Portal (publishedVersion, other-oa)
- Työväentutkimus Vuosikirja (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (IRT13016, 2018QYTD01, 81627901, 81803018, 81773653, 81672937, 2015CB931800, 2018YFA0208900)
- Huazhong University of Science and Technology (2018QYTD01)
- Helsinki Institute of Life Science, Helsingin Yliopisto
- National Key Research and Development Program of China (81773653, IRT13016, 81627901, 2018YFA0208900, 2015CB931800)
- Program for Changjiang Scholars and Innovative Research Team in University (IRT13016)
- H2020 European Research Council (825020)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- tumor-derived exosomes, biomimetic nanoparticles, porous silicon nanoparticles, doxorubicin, drug carriers, targeted cancer chemotherapy, exocytosis, cancer stem cells, tumor accumulation, extravasation, tumor penetration, side population cells, metastatic cancer
- MeSH terms
- Proof of Concept Study, Animals, Disease Models, Animal, Doxorubicin, Drug Carriers, Drug Compounding, Exocytosis, Female, Humans, Male, Neoplasms, Silicon, Neoplastic Stem Cells, Porosity, Spheroids, Cellular, Xenograft Model Antitumor Assays, Cell Line, Tumor, Mice, Nanoparticles, Exosomes
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