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What do we need to know and understand about p53 to improve its clinical value?

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Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment

Rozpędek‐Kamińska, W., Pytel, D., Nowak-Zduńczyk, A., Lewko, D., Wojtczak, R., Diehl, J. A., & Majsterek, I. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180117102233 · Cited by 15 · see citing works

A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo

Comiskey, D. F., Jacob, A. G., Sanford, B. L., Montes, M., Goodwin, A., Steiner, H. E., Matsa, E., Tapia-Santos, A. S., Bebee, T. W., Grieves, J. L., et al. (2017) · Oncogene · doi:10.1038/onc.2017.282 · Cited by 13 · see citing works

Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK/ERK pathway

Che, J., Lu, Y., Sun, K., Feng, C., Dong, A., & Jiao, Y. (2013) · Oncology Reports · doi:10.3892/or.2013.2536 · Cited by 12 · see citing works

Low power lasers on genomic stability

Trajano, L. A. D. S. N., Sergio, L. P. D. S., Stumbo, A. C., Mencalha, A. L., & da Fonseca, A. D. S. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.02.010 · Cited by 11 · see citing works

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice

Carr, M. I., Roderick, J. E., Zhang, H., Woda, B. A., Kelliher, M. A., & Jones, S. N. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611798114 · Cited by 11 · see citing works

Hepatitis C virus Core overcomes all-transretinoic acid-induced apoptosis in human hepatoma cells by inhibitingp14expression via DNA methylation

Kwak, J., Choi, J., & Jang, K. L. (2017) · Oncotarget · doi:10.18632/oncotarget.20337 · Cited by 11 · see citing works

Considering the Role of Murine Double Minute 2 in the Cardiovascular System?

Lam, B., & Roudier, E. A. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00320 · Cited by 11 · see citing works

Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes

Mujoo, K., Hunt, C. R., PANDITA, R. K., Mauro Ferrari, B., Krishnan, S., Cooke, J. P., Hahn, S. M., & Pandita, T. K. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0743 · Cited by 10 · see citing works

E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting

Ong, J. Y., & Torres, J. Z. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82883 · Cited by 8 · see citing works

Ionizing Radiation Combined with PARP1 Inhibitor Reduces Radioresistance in Prostate Cancer with RB1/TP53 Loss

Fan, Y., Fan, H., Quan, Z., & Wu, X. (2021) · Cancer Investigation · doi:10.1080/07357907.2021.1899200 · Cited by 9 · see citing works

Post-translational regulation enables robust p53 regulation

Shin, Y.-J., Chen, K., Sayed, A. H., Hencey, B., & Shen, X. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-83 · Cited by 9 · see citing works

Weak Magnetic Fields Enhance the Efficacy of Radiation Therapy

Iwamoto, K. S., Sandstrom, R. E., Bryan, M., Liu, Y., Elgart, S. R., Sheng, K., Steinberg, M. L., McBride, W. H., & Low, D. A. (2021) · Advances in Radiation Oncology · doi:10.1016/j.adro.2021.100645 · Cited by 8 · see citing works

Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers

Li, Y., Feng, N.-N., Zhang, G.-H., Wang, Q., Hao, Y.-H., Ya-Nanzhang, Long, C., Li, Y., Brandt‐Rauf, P. W., & Xia, Z.-L. (2013) · International Journal of Occupational Medicine and Environmental Health · doi:10.2478/s13382-013-0155-6 · Cited by 8 · see citing works

Sensitivity‐Enhanced 13C‐NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH

Alik, A., Bouguechtouli, C., Julien, M., Bermel, W., Ghouil, R., Zinn‐Justin, S., & Theillet, F. (2020) · Angewandte Chemie · doi:10.1002/ange.202002288 · Cited by 8 · see citing works

What a Difference a Phosphate Makes: Life or Death Decided by a Single Amino Acid in MDM2

Li, Y., & Wahl, G. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.033 · Cited by 6 · see citing works

Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

Uhrík, L., Wang, L., Hároníková, L., Medina‐Medina, I., Rebolloso‐Gómez, Y., Chen, S., Vojtěšek, B., Fåhræus, R., Hernychová, L., & Olivares‐Illana, V. (2019) · Biochemical Journal · doi:10.1042/bcj20190687 · Cited by 6 · see citing works

Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms

Karakostis, K., López, I., Peña-Balderas, A. M., Fåhareus, R., & Olivares‐Illana, V. (2020) · Biomolecules · doi:10.3390/biom11010036 · Cited by 6 · see citing works

Intra molecular interactions in the regulation of p53 pathway

Chen, J. (2016) · Translational Cancer Research · doi:10.21037/tcr.2016.09.23 · Cited by 5 · see citing works

The DNA Damage Response Mediates Apoptosis and Tumor Suppression

Baran, K., Rodríguez, D. A., & Green, D. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9302-0_7 · Cited by 6 · see citing works

p53 regulation by ubiquitin and ubiquitin-like modifications

Wang, Y., Zhang, C., Wang, J., & Liu, J. (2022) · Genome Instability & Disease · doi:10.1007/s42764-022-00067-0 · Cited by 5 · see citing works

A Novel Mechanism of Ataxia Telangiectasia Mutated Mediated Regulation of Chromatin Remodeling in Hypoxic Conditions

Likhatcheva, M., Gieling, R. G., Brown, J. A. L., Demonacos, C., & Williams, K. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720194 · Cited by 4 · see citing works

HDM2 and HDMX Proteins in Human Cancer

Hároníková, L., & Vojtěšek, B. (2018) · Klinicka onkologie · doi:10.14735/amko20182s63 · Cited by 4 · see citing works

NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum

Bernardo, S., Brunet, L. J., Thomas, Q. D., Bracquemond, D., Bouclier, C., Colomb, M., Mancini, M., Fabbrizio, E., Santos, A., Rasamizafy, S. F., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00354-9 · Cited by 3 · see citing works

Nucleolus as a cornerstone linking proliferation and metabolism to cellular responses to stress: involvement of transcription factors MYC and p53

Moraleva, A. A., Антипова, Н. В., Pavlov, P., Dobrochaeva, K. L., & Rubtsov, Y. P. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1749992 · Cited by 3 · see citing works

Redox signaling in development: An emerging frontier.

Ulfig, A., & Jakob, U. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.07.005 · Cited by 1 · see citing works

Novel antagonist APG-115 targets MDM2-p53 to induce p53-mediated apoptosis and radiosensitization in colorectal cancer

Yi, H., Han, Y., Wang, X., Li, Q., Xiong, L., & Li, S. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-026-02049-y · Cited by 3 · see citing works

ATM mutation in aggressive uterine adenosarcoma in which systemic chemotherapies had remarkable effects

Koyama, M., Yamaguchi, K. D., Chigusa, Y., Yamanoi, K., Taki, M., Sunada, M., Horie, A., Hamanishi, J., Minamiguchi, S., & Mandai, M. (2023) · International Cancer Conference Journal · doi:10.1007/s13691-022-00591-6 · Cited by 2 · see citing works

hCINAP alleviates senescence by regulating MDM2 via p14ARF and the HDAC1/CoREST complex

Huang, X., Zhao, Y. T., Wei, M., Zhuge, R., & Zheng, X. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad015 · Cited by 2 · see citing works

The Role of the DNA Damage Response in Ataxia-Telangiectasia Syndrome

Ribes‐Zamora, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84902 · Cited by 1 · see citing works

Mitochondrial translocation of MDM2 and TFAM reprograms metabolism in treatment-refractory cancers

Eu, J. Q., Salleh, N. A. B. M., Hirpara, J. L., Ohi, N., Omori, E., Tan, T. Z., Seet, J. E., Hue, S. S., Chan, S. J., Lim, D. X. Y., et al. (2026) · npj Precision Oncology · doi:10.1038/s41698-025-01257-1 · Cited by 1 · see citing works

Analysis of ATM signaling pathway as an activator of p53 and NF-kB regulatory modules and the role of PPM1D.

Puszyński, K., Jonak, K., Kurpas, M. K., Janus, P., & Szołtysek, K. (2014) · IWBBIO · Cited by 1 · see citing works

Dynamics of the p53 response to ionizing and ultraviolet radiationPreprint

Fedak, E. A., Adler, F. R., Young, E. L., Abegglen, L. M., & Schiffman, J. D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/367995 · Cited by 1 · see citing works

Expression levels of MDM2 and MDMX proteins and their associated effects on P53 in human liposarcomas

Touqan, N. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)

Towards the Investigation of the Effects of Nitration on the Activity of the Human p53 Tumour Suppressor Protein. Nitration of the p53 Tumour Suppressor Protein

Husaini, R. (2014) · Bradford Scholars (University of Bradford)

THE IMPACT OF HISTAMINE RECEPTOR 2 ANTAGONISTS ON BREAST CANCER DEVELOPMENT AND MONOCYTIC POPULATIONS

Vila, A. (2018) · DalSpace (Dalhousie University)

In Vivo Discoveries in MDM2-Mediated p53 Regulation

Tackmann, N. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/z7ta-7m83

Zusammenhänge zwischen TP53-Mutationsstatus, genetischer Instabilität und Prognose bei MDS und sekundärer AML mit komplex aberrantem Karyotyp

Schaab, R. (2020) · doi:10.53846/goediss-7883

Characterization of NEK10 Tyrosine Kinase Activity in the Cellular Response to DNA Damage

Haider, N. (2018) · TSpace (University of Toronto)

Characterization of synthetic lethality between Mdm2 overexpression and genotoxic agents and identification of a novel function of the Mdmx oncogene in DNA repair

Carrillo, A. M. (2014)

Effect of stress during neutron irradiation on the microstructure of type 316 stainless steel

Brager, H. R., Garner, F. A., & Guthrie, G. L. (1976) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)

Funktionen von Trp53 in der Homöostase des Bronchialepithels und der Kontrolle pulmonaler Entzündungsreaktionen als modellhafte Perspektive auf die COPD

Scharte, J. M. (2021) · doi:10.53846/goediss-8911

3’UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activityPreprint

Hu, L., Misra, S., Karim, B. O., Kuhn, S. A., Salotti, J., Basu, S., Martín, N. C. R., Saylor, K. L., & Johnson, P. F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.04.487038

MDM2 (Murine Double Minute 2)

Bang, S., Bhatt, H. C., Chen, Y. Y., & Kurokawa, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101574

MDM2 (Murine Double Minute 2)

Bang, S., Bhatt, H. C., Chen, Y. Y., & Kurokawa, M. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101574-1

Non-canonical functions of the MDM2 oncoprotein

Manzini, V. (2022) · doi:10.53846/goediss-9537

Análise dos mecanismos de checkpoint e reparo de DNA em Trypanosoma brucei em resposta a quebras de DNA.

Muñoz, P. A. M. (2019) · doi:10.11606/t.42.2019.tde-13032023-180307

Germ cell tumor treatment resistance and liquid biopsy-based microRNA biomarkers

Timmerman, D. M. (2024) · doi:10.33540/2055

MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapyPreprint

Bernardo, S., Thomas, Q. D., Mancini, M., Santos, A., Rasamizafy, S. F., Maacha, A.-M., Giry, A., Bousquet, E., Papon, L., Goussard, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.29.591624

CD8 + T cells in patients with hypopharyngeal squamous cell carcinoma are susceptible to radiation‐induced damage

Lin, H., Ma, J., Heng, Y., Zhu, X., Jin, Q.-Y., Ding, X., Tao, L., & Lu, L. (2025) · International Journal of Cancer · doi:10.1002/ijc.35329

Études structurales de ligands peptidomimétiques de TRAIL complexés au récepteur de mort DR5

Baudin, A. (2018) · doi:10.70675/84804ca7zb134z443fz9d8czcc18ce1b7d50

Notch activation upon DNA damage : molecular characterisation and therapeutic applications in lung adenocarcinoma

Bernardo, S. (2019) · doi:10.70675/df87afcbz5843z4c32z9d7cz074065a8acf1

Plk1 mitotic phosphorylation in the N-terminal region of the BRCA2 protein : identification, characterization and role in protein interactions

Julien, M. (2021) · doi:10.70675/0cb10488z985dz4ef1zb4a3z3b031b24f069

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

Maya, R., Balass, M., Kim, S.-T., Shkedy, D., Leal, J.-F. M., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., et al. (2001) · Genes & Development · doi:10.1101/gad.886901 · Cited by 716 · see citing works

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis

Carr, M. I., Roderick, J. E., Gannon, H., Kelliher, M. A., & Jones, S. N. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.014 · Cited by 34 · see citing works

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Chehab, N. H., Malikzay, A., Stavridi, E. S., & Halazonetis, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13777 · Cited by 583 · see citing works

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

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