The role of ubiquitin modification in the regulation of p53
Open accessAbstract
The p53 tumor suppressor protein is involved in regulating a wide variety of stress responses, from senescence and apoptosis to more recently discovered roles in allowing adaptation to metabolic and oxidative stress. After 34years of research, significant progress has been made in unraveling the complexity of the p53 network, and it is clear that the regulation of p53 protein stability is critical in the control of p53 activity. This article focuses on our current understanding of how the level and activity of p53 is controlled by this seemingly simple mechanism. This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf.
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MDM2 can cooperate with MDMX to kinetically enhance p53 polyubiquitination, resulting in p53 stability and tumor occurrence.
“MDM2 can cooperate with MDMX (mouse double minute X) to kinetically enhance p53 polyubiquitination, resulting in p53 stability and the occurrence of tumors [11–13].”
From Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials (2022) · cites this paper as [11]
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- Authors
- Hock, A. K., & Vousden, K. H.
- Affiliations
- Cancer Research UK Scotland Institute (GB)
- Corresponding author
- Vousden, Karen H.
- ORCID
- Vousden, Karen H.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 1843
- Issue
- 1
- Pages
- 137-149
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2062976534
- Cited by
- 168
- References
- 275
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 9 · 2022: 12 · 2021: 27 · 2020: 9 · 2019: 9 · 2018: 15 · 2017: 17 · 2016: 18 · 2015: 19 · 2014: 15 · 2013: 3
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- CR-UK
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- p53, ubiquitin modification, protein stability, ubiquitin-proteasome system, tumor suppressor regulation, apoptosis, senescence, oxidative stress, metabolic stress, stress response
- MeSH terms
- Animals, Humans, Protein Processing, Post-Translational, Transcriptional Activation, Tumor Suppressor Protein p53, Ubiquitin, Proto-Oncogene Proteins c-mdm2, Ubiquitination, Protein Stability
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