Genome Stability Requires p53

Eischen, Christine M.

doi:10.1101/cshperspect.a026096

Cited by 165Cancer-related Molecular PathwaysDNA Repair MechanismsCell death mechanisms and regulation

Genome Stability Requires p53

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Eischen, Christine M.·2016·Cold Spring Harbor Perspectives in Medicine

DOI 10.1101/cshperspect.a026096PMC PMC4888814

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Abstract

It is now clear that functional p53 is critical to protect the genome from alterations that lead to tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 activation, much remains unknown about how p53 maintains genome stability and the proteins involved. The current understanding of the multiple ways p53 contributes to genome stability and how two of its negative regulators, Mdm2 and Mdmx, induce genome instability will be described.

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Loss of TP53 and RB1 likely occurs early in osteosarcoma transformation, with TP53 inactivation required to propagate abnormal genomes, followed by rapid accumulation of driver lesions such as MYC amplification, PTEN loss and deletion of ATRX.
“Using these genomic aberrations to infer the evolution of the tumours, loss of TP53 and RB1 likely occurs early in the transformation process (with TP53 inactivation required to propagate abnormal genomes 39,40,41 ), followed by rapid accumulation of driver lesions such as MYC amplification, PTEN loss 42 and deletion of ATRX”
From Osteosarcoma (2022) · cites this paper as [40]
The most likely order of events for osteosarcoma evolution is loss of TP53 and RB1 as early events, with TP53 loss likely initiating genomic instability, followed by whole-genome doubling, gain of 8q (CMYC) and loss of 10q (PTEN).
“The most likely order of events for osteosarcoma evolution is loss of TP53 and RB1 as early events, of which TP53 loss is likely the initiator of genomic instability 39,40,41 followed by whole-genome doubling, gain of 8q (CMYC) and loss of 10q (PTEN) 42 .”
From Osteosarcoma (2022) · cites this paper as [40]

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Mendrysa, S. M., McElwee, M. K., Michalowski, J., O'Leary, K. A., Young, K. M., & Perry, M. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.462-473.2003 · Cited by 234 · see citing works
Tumor suppressor p53 meets microRNAs
Feng, Z., Zhang, C., Wu, R., & Hu, W. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq040 · Cited by 232 · see citing works
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.
Pantoja, C., & Serrano, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202880 · Cited by 201 · see citing works
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197 · see citing works
Genomic instability and apoptosis are frequent in p53 deficient young mice
Fukasawa, K., Wiener, F., Woude, G. F. V., & Mai, S. (1997) · Oncogene · doi:10.1038/sj.onc.1201482 · Cited by 194 · see citing works
p53: Guardian of ploidy
Aylon, Y., & Oren, M. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.07.007 · Cited by 190 · see citing works
p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.Preprint
Ewen, M. E., Oliver, C. J., Sluss, H. K., Miller, S. J., & Peeper, D. S. (1995) · Genes & Development · doi:10.1101/gad.9.2.204 · Cited by 165 · see citing works
Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway
Tarapore, P., Horn, H. F., Tokuyama, Y., & Fukasawa, K. (2001) · Oncogene · doi:10.1038/sj.onc.1204424 · Cited by 158 · see citing works
Younger Age of Cancer Initiation Is Associated with Shorter Telomere Length in Li-Fraumeni Syndrome
Tabori, U. Y., Nanda, S., Druker, H. A., Lees, J., & Malkin, D. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3682 · Cited by 149 · see citing works
Another fork in the road—life or death decisions by the tumour suppressor p53
Carvajal, L. A., & Manfredi, J. J. (2013) · The EMBO Reports · doi:10.1038/embor.2013.25 · Cited by 149 · see citing works
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
Vitale, I., Senovilla, L., Jemaà, M., Michaud, M., Galluzzi, L., Kepp, O., Nanty, L., Criollo, A., Rello‐Varona, S., Manic, G., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.11 · Cited by 146 · see citing works
The good, the bad and the ugly: the practical consequences of centrosome amplification
Sluder, G., & Nordberg, J. J. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.006 · Cited by 136 · see citing works
Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair
Alt, J. R., Bouska, A., Fernandez, M. R., Cerny, R. L., Xiao, H., & Eischen, C. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413387200 · Cited by 131 · see citing works
Self-citation
Mdm2 haplo‐insufficiency profoundly inhibits Myc‐induced lymphomagenesis
Alt, J. R., Greiner, T. C., Cleveland, J. L., & Eischen, C. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg133 · Cited by 129 · see citing works
Self-citation
Mechanisms of aneuploidy
Compton, D. A. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.007 · Cited by 128 · see citing works
Attenuating the p53 Pathway in Human Cancers: Many Means to the Same EndPreprint
Wasylishen, A. R., & Lozano, G. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026211 · Cited by 128 · see citing works
Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma
Bakhoum, S. F. W., Danilova, O. V., Kaur, P., Levy, N. B., & Compton, D. A. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2049 · Cited by 126 · see citing works
p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells
Mantel, C., Braun, S. E., Reid, S., Henegariu, O., Liu, L., Hangoc, G., & Broxmeyer, H. E. (1999) · Blood · doi:10.1182/blood.v93.4.1390.404k25_1390_1398 · Cited by 120 · see citing works
p21 delays tumor onset by preservation of chromosomal stability
Barboza, J., Liu, G., Ju, Z., El‐Naggar, A. K., & Lozano, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606343104 · Cited by 108 · see citing works
Mdm2 Promotes Genetic Instability and Transformation Independent of p53
Bouska, A., Lushnikova, T., Plaza, S., & Eischen, C. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01584-07 · Cited by 105 · see citing works
Self-citation
ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice
Gannon, H. S., Woda, B. A., & Jones, S. N. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.011 · Cited by 105 · see citing works
Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes
Smid, M., Hoes, M., Sieuwerts, A. M., Sleijfer, S., Zhang, Y., Wang, Y., Foekens, J. A., & Martens, J. W. M. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1026-5 · Cited by 96 · see citing works
p53 REGULATES A MITOTIC TRANSCRIPTION PROGRAM AND DETERMINES PLOIDY IN NORMAL MOUSE LIVER
Kurinna, S., Stratton, S., Coban, Z., Schumacher, J. M., Grompe, M., Duncan, A. W., & Barton, M. (2013) · Hepatology · doi:10.1002/hep.26233 · Cited by 92 · see citing works
Increased Tumor Proliferation and Genomic Instability without Decreased Apoptosis in MMTV-ras Mice Deficient in p53
Hundley, J. E., Koester, S. K., Troyer, D. A., Hilsenbeck, S. G., Subler, M. A., & Windle, J. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.723 · Cited by 92 · see citing works
p73 Suppresses Polyploidy and Aneuploidy in the Absence of Functional p53
Talos, F., Nemajerová, A., Flores, E. R., Petrenko, O., & Moll, U. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.036 · Cited by 91 · see citing works
Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells
Adon, A. M., Zeng, X., Harrison, M. K., Sannem, S., Kiyokawa, H., Kaldis, P., & Saavedra, H. I. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00253-09 · Cited by 91 · see citing works
Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication
Shinmura, K., Bennett, R. A. O., Tarapore, P., & Fukasawa, K. (2006) · Oncogene · doi:10.1038/sj.onc.1210085 · Cited by 87 · see citing works
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
Wang, P., Lushnikova, T., Odvody, J., Greiner, T. C., Jones, S. N., & Eischen, C. M. (2008) · Oncogene · doi:10.1038/sj.onc.1210788 · Cited by 86 · see citing works
Self-citation
Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Xiong, S., Pant, V., Suh, Y.-A., Van Pelt, C. S., Wang, Y., Valentin-Vega, Y. A., Post, S. M., & Lozano, G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1457 · Cited by 82 · see citing works
The Mdm network and its regulation of p53 activities: a rheostat of cancer risk
Eischen, C. M., & Lozano, G. (2014) · Human Mutation · doi:10.1002/humu.22524 · Cited by 79 · see citing works
Self-citation
Mitochondrial Liaisons of p53
Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Pinti, M., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3504 · Cited by 74 · see citing works
p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses*
Hünten, S., Kaller, M., Drepper, F., Oeljeklaus, S., Bonfert, T., Erhard, F., Dueck, A., Eichner, N., Friedel, C., Meister, G., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.050237 · Cited by 72 · see citing works
Mdmx promotes genomic instability independent of p53 and Mdm2
Carrillo, A. M., Bouska, A., Arrate, M. P., & Eischen, C. M. (2015) · Oncogene · doi:10.1038/onc.2014.27 · Cited by 69 · see citing works
Self-citation
New insights into p53 functions through its target microRNAs
Liao, J.-M., Cao, B., Zhou, X. Y., & Lu, H. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju018 · Cited by 69 · see citing works
MdmX Promotes Bipolar Mitosis To Suppress Transformation and Tumorigenesis in p53-Deficient Cells and Mice
Matijasevic, Z., Steinman, H. A., Hoover, K., & Jones, S. N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01108-07 · Cited by 58 · see citing works
Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity
Notterman, D. A., Young, S.-M., Wainger, B. J., & Levine, A. J. (1998) · Oncogene · doi:10.1038/sj.onc.1202210 · Cited by 55 · see citing works
Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model
Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0237 · Cited by 42 · see citing works
Self-citation
Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression
Lushnikova, T., Bouska, A., Odvody, J., Dupont, W. D., & Eischen, C. M. (2011) · Oncogene · doi:10.1038/onc.2011.172 · Cited by 40 · see citing works
Self-citation
A Role of p73 in Mitotic Exit
Merlo, P., Fulco, M., Costanzo, A., Mangiacasale, R., Strano, S., Blandino, G., Taya, Y., Lavia, P., & Levrero, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500635200 · Cited by 40 · see citing works
p53mutations associated with aging-related rise in cancer incidence rates
Richardson, R. B. (2013) · Cell Cycle · doi:10.4161/cc.25494 · Cited by 40 · see citing works
Inactivation of p53 and the Development of Tetraploidy in the Elastase-SV40 T Antigen Transgenic Mouse Pancreas
Ramel, S., Sanchez, C. A., Schimke, M. K., Neshat, K., Cross, S. M., Raskind, W. H., & Reid, B. J. (1995) · Pancreas · doi:10.1097/00006676-199510000-00001 · Cited by 36 · see citing works
MdmX regulates transformation and chromosomal stability in p53-deficient cells
Matijasevic, Z., Krzywicka-Racka, A., Sluder, G., & Jones, S. N. (2008) · Cell Cycle · doi:10.4161/cc.7.19.6797 · Cited by 34 · see citing works
Pharmacologically increasing Mdm2 Inhibits DNA repair and cooperates with genotoxic agents to kill p53-inactivated ovarian cancer cells
Carrillo, A. M., Hicks, M., Khabele, D., & Eischen, C. M. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0089 · Cited by 31 · see citing works
Self-citation
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death
Conradt, L., Henrich, A., Wirth, M., Reichert, M., Lesina, M., Algül, H., Schmid, R. M., Krämer, O. H., Saur, D., & Schneider, G. (2013) · International Journal of Cancer · doi:10.1002/ijc.27916 · Cited by 30 · see citing works
Decreased Mdm2 expression inhibits tumor development induced by loss of ARF
Wang, P., Greiner, T. C., Lushnikova, T., & Eischen, C. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209411 · Cited by 29 · see citing works
Self-citation
Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells
Beishline, K., & Azizkhan‐Clifford, J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_3 · Cited by 29 · see citing works
The MRE11 complex: An important source of stress relief
Rein, K., & Stracker, T. H. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.10.010 · Cited by 27 · see citing works
P53 EXPRESSION IS ASSOCIATED WITH A HIGH-DEGREE OF TUMOR DNA ANEUPLOIDY AND INCIDENCE OF P53 GENE MUTATION, AND IS LOCALIZED TO THE ANEUPLOID COMPONENT IN COLORECTAL CARCINOMAS
DeAngelis, P. M., Stokke, T., Smedshammer, L., Lothe, R. A., Meling, G. I., ROFSTAD, M., Chen, Y., & CLAUSEN, O. (1993) · International Journal of Oncology · doi:10.3892/ijo.3.2.305 · Cited by 25 · see citing works
Protecting the genome from mdm2 and mdmx
Melo, A. N., & Eischen, C. M. (2012) · Genes & Cancer · doi:10.1177/1947601912454139 · Cited by 20 · see citing works
Self-citation
Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma
Riley, M. F., You, M. J., Multani, A. S., & Lozano, G. (2015) · Oncogene · doi:10.1038/onc.2015.88 · Cited by 19 · see citing works
Decreased Mdm2 Expression Inhibits Tumor Development and Extends Survival Independent of Arf and Dependent on p53
Eischen, C. M., & Boyd, K. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046148 · Cited by 12 · see citing works
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Putting p53 in context
Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906 · see citing works
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works
Osteosarcoma
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications
Mustafa, M., Ahmad, R., Tantry, I. Q., Ahmad, W., Siddiqui, S., Alam, M., Abbas, K., Moinuddin, Hassan, M. I., Habib, S., et al. (2024) · Cells · doi:10.3390/cells13221838 · Cited by 595 · see citing works
Mutant p53 Suppresses Innate Immune Signaling to Promote Tumorigenesis
Ghosh, M., Saha, S., Bettke, J. A., Nagar, R., Parrales, A., Iwakuma, T., van der Velden, A. W. M., & Martinez, L. A. (2020) · Cancer Cell · doi:10.1016/j.ccell.2021.01.003 · Cited by 344 · see citing works
Signaling pathways and therapeutic interventions in gastric cancer
Lei, Z., Teng, Q., Qin, T. L., Chen, W., Xie, Y., Wu, K., Zeng, Q., Zeng, L., Pan, Y., Chen, Z., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01190-w · Cited by 325 · see citing works
p53 and Tumor Suppression: It Takes a Network
Boutelle, A. M., & Attardi, L. D. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.011 · Cited by 322 · see citing works
Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments
Yip, H. Y. K., & Papa, A. (2021) · Cells · doi:10.3390/cells10030659 · Cited by 332 · see citing works
Ordered and deterministic cancer genome evolution after p53 loss
Baslan, T., Morris, J. P., Zhao, Z., Reyes, J., Ho, Y.-J., Tsanov, K. M., Bermeo, J., Tian, S., Zhang, S., Askan, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05082-5 · Cited by 221 · see citing works
Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Luebeck, J., Ng, A. W. T., Galipeau, P. C., Li, X., Sanchez, C. A., Katz‐Summercorn, A., Kim, H., Jammula, S., He, Y., Lippman, S. M., et al. (2023) · Nature · doi:10.1038/s41586-023-05937-5 · Cited by 172 · see citing works
Exploring the multiple roles of guardian of the genome: P53
Feroz, W., & Sheikh, A. M. A. (2020) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-020-00089-x · Cited by 161 · see citing works
Cancer type-dependent correlations between TP53 mutations and antitumor immunity
Li, L., Li, M., & Wang, X. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102785 · Cited by 148 · see citing works
Correlate the TP53 Mutation and the HRAS Mutation with Immune Signatures in Head and Neck Squamous Cell Cancer
Lyu, H., Li, M., Jiang, Z., Liu, Z., & Wang, X. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.07.009 · Cited by 134 · see citing works
p53: emerging roles in stem cells, development and beyond
Jain, A. K., & Barton, M. C. (2018) · Development · doi:10.1242/dev.158360 · Cited by 121 · see citing works
USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis
Costa, L., Corre, S., Michel, V., Luel, K. L., Fernandes, J., Ziveri, J., Jouvion, G., Danckaert, A., Mouchet, N., Barreira, D. D. S., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318640 · Cited by 114 · see citing works
p53 directly represses human LINE1 transposonsPreprint
Tiwari, B., Jones, A. E., Caillet, C. J., Das, S., Royer, S. K., & Abrams, J. (2020) · Genes & Development · doi:10.1101/gad.343186.120 · Cited by 113 · see citing works
An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles
Li, M., Zhang, Z., Li, L., & Wang, X. (2020) · Communications Biology · doi:10.1038/s42003-020-01230-7 · Cited by 101 · see citing works
The American lobster genome reveals insights on longevity, neural, and immune adaptations
Polinski, J. M., Zimin, A. V., Clark, K. F., Kohn, A. B., Sadowski, N., Timp, W., Ptitsyn, A. A., Khanna, P., Romanova, D. Y., Williams, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe8290 · Cited by 90 · see citing works
Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy
Ramirez, J. A. Z., Romagnoli, G. G., & Kaneno, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118745 · Cited by 88 · see citing works
The Role of TP53 Mutations in EGFR-Mutated Non-Small-Cell Lung Cancer: Clinical Significance and Implications for Therapy
Canale, M., Andrikou, K., Priano, I., Cravero, P., Pasini, L., Urbini, M., Delmonte, A., Crinò, L., Bronte, G., & Ulivi, P. (2022) · Cancers · doi:10.3390/cancers14051143 · Cited by 93 · see citing works
Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology
Mühleder, S., Fernández-Chacón, M., García-Gónzalez, I., & Benedito, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03664-y · Cited by 79 · see citing works
Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development
Chang, J., Zhao, X., Wang, Y., Liu, T., Zhong, C., Lao, Y., Zhang, S., Liao, H., Bai, F., Lin, D., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.11.003 · Cited by 80 · see citing works
Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution
Shingate, P., Ravi, V., Prasad, A., Tay, B.-H., Garg, K. M., Chattopadhyay, B., Yap, L.-M., Rheindt, F. E., & Venkatesh, B. (2020) · Nature Communications · doi:10.1038/s41467-020-16180-1 · Cited by 76 · see citing works
Omics-Based Investigations of Breast Cancer
Neagu, A.-N., Whitham, D., Bruno, P. S., Morrissiey, H., Darie, C. A., & Darie, C. C. (2023) · Molecules · doi:10.3390/molecules28124768 · Cited by 79 · see citing works
Functions of p53 in pluripotent stem cells
Fu, X., Wu, S., Li, B., Xu, Y., & Liu, J. (2019) · Protein & Cell · doi:10.1007/s13238-019-00665-x · Cited by 78 · see citing works
Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling
Lu, J., Qian, J., Xu, Z., Yin, S., Zhou, L., Zheng, S., & Zhang, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631486 · Cited by 76 · see citing works
Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype
Lee, S. Y., Ju, M. K., Jeon, H. M., Lee, Y. J., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1027453 · Cited by 67 · see citing works
Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?
Janic, A., Abad, E., & Amelio, I. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01259-9 · Cited by 66 · see citing works
Identification of gastric cancer subtypes based on pathway clustering
Li, L., & Wang, X. (2021) · npj Precision Oncology · doi:10.1038/s41698-021-00186-z · Cited by 62 · see citing works
Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden
Zhu, M., Kim, J., Deng, Q., Ricciuti, B., Alessi, J. V., Eglenen-Polat, B., Bender, M. E., Huang, H.-C., Kowash, R. R., Cuevas, I., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.09.006 · Cited by 63 · see citing works
Tumorigenic and Immunogenic Properties of Induced Pluripotent Stem Cells: a Promising Cancer Vaccine
Qiao, Y., Agboola, O. S., Hu, X., Wu, Y., & Lei, L. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10042-5 · Cited by 56 · see citing works
Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response
Zhao, M., Wang, T., Gleber‐Netto, F. O., Chen, Z., McGrail, D. J., Gomez, J. A., Ju, W., Gadhikar, M. A., Ma, W., Shen, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44239-2 · Cited by 60 · see citing works
Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes
Jindal, S., Pennock, N. D., Sun, D., Horton, W. R., Ozaki, M. K., Narasimhan, J., Bartlett, A. Q., Weinmann, S. A., Goss, P. E., Borges, V. F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26505-3 · Cited by 54 · see citing works
ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework
Timofeev, O. N., Giron, P., Lawo, S., Pichler, M., & Noeparast, A. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00554-5 · Cited by 59 · see citing works
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003
Kline, C., Jain, P., Kilburn, L. B., Bonner, E. R., Gupta, N. M., Crawford, J. R., Banerjee, A., Packer, R. J., Villanueva-Meyer, J. E., Luks, T. L., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-0803 · Cited by 53 · see citing works
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Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancerPreprint
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Authors: Eischen, C. M.
Affiliations: Vanderbilt University Medical Center (US)
Corresponding author: Eischen, Christine M.
ORCID: Eischen, Christine M.
Venue: Cold Spring Harbor Perspectives in Medicine
Publisher: Cold Spring Harbor Laboratory
Published: 2016-06
Volume: 6
Issue: 6
Pages: a026096
ISSN: 2157-1422 (ISSN-L)
DOI: 10.1101/cshperspect.a026096
PMC: PMC4888814
OpenAlex: W2410798112
Semantic Scholar: 22e4fde6cdb4eb9c2fdf8afc8725dd9308ce960e
Cited by: 161
References: 135
Citations by year: 2026: 13 · 2025: 17 · 2024: 23 · 2023: 17 · 2022: 32 · 2021: 22 · 2020: 20 · 2019: 8 · 2018: 6 · 2017: 3
Type: posted content
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cold Spring Harbor Perspectives in Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA181204)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, genome stability, carcinogenesis, MDM2, MDMX, p53 activation, cellular stress, genomic instability
MeSH terms: Animals, Cell Transformation, Neoplastic, DNA Damage, Gene Amplification, Humans, Mutation, Nuclear Proteins, Proto-Oncogene Proteins, Tumor Suppressor Protein p53, Cell Cycle Proteins, MicroRNAs, Genomic Instability, Mice, Proto-Oncogene Proteins c-mdm2

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