Cited by 105Cancer-related Molecular PathwaysDNA Repair MechanismsHeat shock proteins research

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ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice

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Gannon, Hugh S., Woda, Bruce A., Jones, Stephen N.·2012·Cancer Cell

DOI 10.1016/j.ccr.2012.04.011PMC PMC3360886

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Abstract

DNA damage induced by ionizing radiation activates the ATM kinase, which subsequently stabilizes and activates the p53 tumor suppressor protein. Although phosphorylation of p53 by ATM was found previously to modulate p53 levels and transcriptional activities in vivo, it does not appear to be a major regulator of p53 stability. We have utilized mice bearing altered Mdm2 alleles to demonstrate that ATM phosphorylation of Mdm2 serine 394 is required for robust p53 stabilization and activation after DNA damage. In addition, we demonstrate that dephosphorylation of Mdm2 Ser394 regulates attenuation of the p53-mediated response to DNA damage. Therefore, the phosphorylation status of Mdm2 Ser394 governs p53 protein levels and functions in cells undergoing DNA damage.

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Authors: Gannon, H. S., Woda, B. A., & Jones, S. N.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Jones, Stephen N.
ORCID: Gannon, Hugh S.
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2012-05
Volume: 21
Issue: 5
Pages: 668-679
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2012.04.011
PMC: PMC3360886
OpenAlex: W2117932700
Cited by: 105
References: 48
Citations by year: 2026: 7 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 13 · 2015: 4 · 2014: 11 · 2013: 10 · 2012: 6
FWCI: 4.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 442 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (CA077735)
National Cancer Institute
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords: ATM kinase, MDM2, p53 stabilization, DNA damage response, ionizing radiation, p53 activation
MeSH terms: Animals, DNA Damage, DNA-Binding Proteins, Enzyme Activation, Intestine, Small, Mice, Inbred C57BL, Phosphorylation, Radiation Tolerance, Serine, Spleen, Thymus Gland, Time Factors, Tumor Suppressor Protein p53, Apoptosis, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Mutation, Missense, Tumor Suppressor Proteins, Mice, Proto-Oncogene Proteins c-mdm2, Protein Stability, Mice, 129 Strain, Ataxia Telangiectasia Mutated Proteins

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ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice

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