The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway
Open accessAbstract
Increased expression of the chemokine CCL2 in tumor cells correlates with enhanced metastasis, poor prognosis, and recruitment of CCR2(+)Ly6C(hi) monocytes. However, the mechanisms driving tumor cell extravasation through the endothelium remain elusive. Here, we describe CCL2 upregulation in metastatic UICC stage IV colon carcinomas and demonstrate that tumor cell-derived CCL2 activates the CCR2(+) endothelium to increase vascular permeability in vivo. CCR2 deficiency prevents colon carcinoma extravasation and metastasis. Of note, CCR2 expression on radio-resistant cells or endothelial CCR2 expression restores extravasation and metastasis in Ccr2(-/-) mice. Reduction of CCR2 expression on myeloid cells decreases but does not prevent metastasis. CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling. Our study identifies potential targets for treating CCL2-dependent metastasis.
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Cites
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Cited by
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Metadata
- Authors
- Wolf, M. J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Stürzl, M., Croner, R. S., Konrad, A., Manz, M. G., Moch, H., Aguzzi, A., van Loo, G., Pasparakis, M., Prinz, M., Borsig, L., & Heikenwalder, M.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 22
- Issue
- 1
- Pages
- 91-105
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2063470457
- Cited by
- 290
- References
- 40
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wolf, M. J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Stürzl, M., Croner, R. S., Konrad, A., Manz, M. G., Moch, H., Aguzzi, A., van Loo, G., Pasparakis, M., Prinz, M., Borsig, L., & Heikenwalder, M. (2012). Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway. Cancer Cell. https://doi.org/10.1016/j.ccr.2012.05.023
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