Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
Liang, Jie, Nagahashi, Masayuki, Kim, Eugene Y., Harikumar, Kuzhuvelil B., Yamada, Akimitsu, Huang, Wei-Ching, Hait, Nitai C., Allegood, Jeremy C. +6 more·2013·Cancer Cell
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- Role of neutral ceramidase in colon cancerMónica Garcı́a-Barros, Nicolas Coant, Toshihiko Kawamori, Masayuki Wada, Ashley J. Snider, Jean‐Philip Truman, Bill Xingjun Wu, Hideki Furuya, Christopher J. Clarke, Agnieszka B. Bialkowska et al. · 2016 · The FASEB Journal
- Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling PathwayIrene Crespo, Beatriz San‐Miguel, Jose Luis Mauriz, Juan José Ortiz de Urbina, Mar Almar, María Jesús Tuñón, Javier González‐Gallego · 2017 · Nutrients
- Hypothalamic S1P/S1PR1 axis controls energy homeostasisVagner Ramon Rodrigues Silva, Thayana Oliveira Micheletti, Gustavo D. Pimentel, Carlos K. Katashima, Luciene Lenhare, Joseane Morari, Maria Carolina Santos Mendes, Daniela Soares Razolli, Guilherme Z. Rocha, Cláudio Teodoro de Souza et al. · 2014 · Nature Communications
- Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathyKawai, Hironari, Osawa, Yosuke, Matsuda, Michitaka, Tsunoda, Tomoyuki, Yanagida, Keisuke, Hishikawa, Daisuke, Okawara, Miku, Sakamoto, Yuzuru, Shimagaki, Tomonari, Tsutsui, Yuriko et al. · 2022 · Hepatology
- Sphingosine Kinases Are Not Required for Inflammatory Responses in MacrophagesYuquan Xiong, Hyeuk Jong Lee, Boubacar Mariko, Yi-Chien Lu, Andrew J. Dannenberg, Abigail S. Haka, Frederick R. Maxfield, Eric Camerer, Richard L. Proia, Timothy Hla · 2013 · Journal of Biological Chemistry
- Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissuesChunyi Wang, Jinghe Mao, Samantha Redfield, Yin‐Yuan Mo, Janice M. Lage, Xinchun Zhou · 2014 · Experimental and Molecular Pathology
- Sphingosine-1-Phosphate Signaling in Inflammatory Bowel DiseaseOle Haagen Nielsen, Yuan Li, Bengt Johansson‐Lindbom, Mehmet Coskun · 2017 · Trends in Molecular Medicine
- S1PR1 as a Novel Promising Therapeutic Target in Cancer TherapyN. Rostami, A. Nikkhoo, Amir Ajoolabady, G. Azizi, M. Hojjat-Farsangi, G. Ghalamfarsa, B. Yousefi, M. Yousefi, Farhad Jadidi-Niaragh · 2019 · Molecular Diagnosis & Therapy
- MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cellsPeng Zhou, Gang Huang, Yuanyin Zhao, Dan Zhong, Zhizhen Xu, Yijun Zeng, Yan Zhang, Song Li, Fengtian He · 2014 · Cellular Signalling
- Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and LymphangiogenesisWei‐Ching Huang, Masayuki Nagahashi, Krista P. Terracina, Kazuaki Takabe · 2013 · Biomolecules
- FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke TreatmentZifeng Wang, Masahito Kawabori, Kiyohiro Houkin · 2019 · Current Medicinal Chemistry
- Recent advances in the role of sphingosine 1‐phosphate in cancerNigel J. Pyne, Susan Pyne · 2020 · FEBS Letters
- STAT3 in hepatocellular carcinoma: new perspectivesSvinka, Jasmin, Mikulits, Wolfgang, Eferl, Robert · 2014 · Hepatic Oncology
- STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.Andrew V. Nguyen, Yuan-Yuan Wu, E. Lin · 2014 · World Journal of Gastroenterology
- FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph NodesYanping Han, Xing Li, Qingyou Zhou, Hongyu Jie, Xiaobin Lao, Jiaochan Han, Juan He, Xinxia Liu, Dongsheng Gu, Yi He et al. · 2015 · The Journal of Immunology
- Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer TreatmentAlhaji H. Janneh, Besim Öğretmen · 2022 · Cancers
- S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent PathwaysRose Z. Hill, Takeshi Morita, Rachel B. Brem, Diana M. Bautista · 2018 · Journal of Neuroscience
- Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic SignalingVijay Avin Balaji Ragunathrao, Mumtaz Anwar, Md Zahid Akhter, Alejandra Chavez, De Yu Mao, Viswanathan Natarajan, Sribalaji Lakshmikanthan, Magdalena Chrzanowska‐Wodnicka, Arkadiusz Zbigniew Dudek, Lena Claesson et al. · 2019 · Cell Reports
- The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responsesCarole A. Oskeritzian, Nitai C. Hait, Piper Wedman, Alena P. Chumanevich, Elizabeth Motunrayo Kolawole, Megan M. Price, Yves T. Falanga, Kuzhuvelil B. Harikumar, John Jake Ryan, Sheldon Milstien et al. · 2014 · Journal of Allergy and Clinical Immunology
- Lymph Nodes and Cancer Metastasis: New Perspectives on the Role of Intranodal Lymphatic SinusesRui‐Cheng Ji · 2016 · International Journal of Molecular Sciences
- De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal CancerNaser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Young Lee, Heidi L. Weiss et al. · 2018 · Molecular Cancer Research
- Colon Cancer and Perturbations of the Sphingolipid MetabolismMiroslav Machala, Jiřina Procházková, Jiřina Hofmanová, Lucie Králíková, Josef Slavík, Zuzana Tylichová, Petra Ovesná, Alois Kozubı́k, Jan Vondráček · 2019 · International Journal of Molecular Sciences
- An oncogenic role for sphingosine kinase 2Heidi Anne Neubauer, Duyen Pham, Julia R. Zebol, Paul A.B. Moretti, Amanda L. Peterson, Tamara M. Leclercq, Huasheng Chan, Jason A. Powell, Melissa R. Pitman, Michael Susithiran Samuel et al. · 2016 · Oncotarget
- TRIM14 promotes colorectal cancer cell migration and invasion through the SPHK1/STAT3 pathwayZhonghai Jin, Hongguang Li, Xiaofei Hong, Guangrong Ying, Xiaofeng Lu, Li-Lei Zhuang, Shenbao Wu · 2018 · Cancer Cell International
- High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expressionRenata Feuerborn, Susen Becker, Francesco Potì, Petra Nagel, Martin F. Brodde, Harmut Schmidt, Christina Christoffersen, Uta Ceglarek, Ralph Burkhardt, Jerzy–Roch Nofer · 2016 · Atherosclerosis
- Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join ForcesLoubna Abdel Hadi, Clara Di Vito, Laura Riboni · 2016 · Mediators of Inflammation
- The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic PerspectivesAlexandra Lucaciu, Robert Brunkhorst, Josef M. Pfeilschifter, Waltraud Pfeilschifter, Julien Subburayalu · 2020 · Cells
- Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-DiseasesYanhong Bu, Hong Wu, Ran Deng, Yan Wang · 2021 · Frontiers in Pharmacology
- mPGES-1 and ALOX5/-15 in tumor-associated macrophagesAndreas Weigert, Elisabeth Strack, Ryan G. Snodgrass, Bernhard Brüne · 2018 · Cancer and Metastasis Reviews
- STAT3 in Epithelial Cells Regulates Inflammation and Tumor Progression to Malignant State in ColonAndrew Nguyen, Yuanyuan Wu, Qiang Liu, Donghai Wang, Stephanie A. Nguyen, Ricky Loh, Joey Pang, Kenneth A. Friedman, Amos Orlofsky, Leonard H. Augenlicht et al. · 2013 · Neoplasia
- Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancerJessica A. Beach, Paul-Joseph P. Aspuria, Dong‐Joo Cheon, Kate Lawrenson, Hasmik Agadjanian, Christine Walsh, Beth Y. Karlan, Sandra Oršulić · 2015 · Oncotarget
- GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress TumorigenesisYangmeng Wang, Hongxiu Ning, Fangli Ren, Yuanjiang Zhang, Yu Rong, Yinyin Wang, Fuqin Su, Chenguang Cai, Zhe Hu Jin, Zhiyong Li et al. · 2014 · Molecular Cell
- Sphingosine‐1‐phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humansWei‐Ching Huang, Jie Liang, Masayuki Nagahashi, Dorit Avni, Akimitsu Yamada, Michael W. Maceyka, Aaron R. Wolen, Tomasz Kordula, Sheldon Milstien, Kazuaki Takabe et al. · 2016 · The FASEB Journal
- Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitisMel Pilar Espaillat, Richard R. Kew, Lina Marie Obeid · 2016 · Advances in Biological Regulation
- Sphingolipids in Obesity and Correlated Co-Morbidities: The Contribution of Gender, Age and EnvironmentEnrica Torretta, Pietro Barbacini, Nasser M. Al‐Daghri, Cecilia Gelfi · 2019 · International Journal of Molecular Sciences
- Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple‐Negative Subtype of Breast Cancer PatientsMasanori Oshi, Stephanie Newman, Yoshihisa Tokumaru, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe · 2020 · Journal of Immunology Research
- Advances and challenges in the molecular biology and treatment of glioblastoma-is there any hope for the future?Ignacio Véliz, Yong Loo, O. Castillo, Niki Karachaliou, Olga Nigro, Rafael Rosell · 2015 · Europe PMC (PubMed Central)
- Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasisJunko Tsuchida, Masayuki Nagahashi, Masato Nakajima, Kazuki Moro, Kumiko Tatsuda, Rajesh Ramanathan, Kazuaki Takabe, Toshifumi Wakai · 2016 · Journal of Surgical Research
- Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate CellsDecai Wang, Shengbo Han, Guozheng Lv, Yuhang Hu, Wenfeng Zhuo, Zhu Zeng, Jiang Tang, Yan Huang, Fan Wang, Jie Wang et al. · 2023 · Gastroenterology
- Epithelial gp130/Stat3 functions: An intestinal signaling node in health and diseaseMatthias Ernst, Stefan Thiem, Paul M. Nguyen, Moritz F. Eissmann, Tracy L. Putoczki · 2014 · Seminars in Immunology
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- Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative ColitisJin Wu, Yiting Luo, Yan Shen, Yuyao Hu, Fangyuan Zhu, Jiaqian Wu, Yingchao Liu · 2022 · Drug Design Development and Therapy
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- Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatmentCheca, Antonio, Xu, Ning, Sar, Daniel G., Haeggström, Jesper Z., Ståhle, Mona, Wheelock, Craig E. · 2015 · Scientific Reports
- Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier RecurrenceBaasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Kenichiro Enooku, Masaya Sato, Daisuke Saigusa, Junken Aoki, Takeaki Ishizawa, Kiyoshi Hasegawa, Norihiro Kokudo et al. · 2016 · PLoS ONE
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- Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis‐associated colon cancerToshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi Kinami, Takeo Kosaka, Toshiro Okazaki · 2017 · The FASEB Journal
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- How cancer cells remodel lipid metabolism: strategies targeting transcription factorsDo‐Won Jeong, Seulbee Lee, Yang‐Sook Chun · 2021 · Lipids in Health and Disease
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