Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer

Liang, Jie, Nagahashi, Masayuki, Kim, Eugene Y., Harikumar, Kuzhuvelil B., Yamada, Akimitsu, Huang, Wei-Ching, Hait, Nitai C., Allegood, Jeremy C. +6 more·2013·Cancer Cell

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Items 101–200 of 564

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  2. Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment
    Yamila I. Rodriguez, Ludmila E. Campos, Melina G. Castro, Ahmed Al-Adhami, Carole A. Oskeritzian, Sergio E. Alvarez · 2016 · Frontiers in Oncology
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    Mónica Garcı́a-Barros, Nicolas Coant, Toshihiko Kawamori, Masayuki Wada, Ashley J. Snider, Jean‐Philip Truman, Bill Xingjun Wu, Hideki Furuya, Christopher J. Clarke, Agnieszka B. Bialkowska et al. · 2016 · The FASEB Journal
  4. Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway
    Irene Crespo, Beatriz San‐Miguel, Jose Luis Mauriz, Juan José Ortiz de Urbina, Mar Almar, María Jesús Tuñón, Javier González‐Gallego · 2017 · Nutrients
  5. Hypothalamic S1P/S1PR1 axis controls energy homeostasis
    Vagner Ramon Rodrigues Silva, Thayana Oliveira Micheletti, Gustavo D. Pimentel, Carlos K. Katashima, Luciene Lenhare, Joseane Morari, Maria Carolina Santos Mendes, Daniela Soares Razolli, Guilherme Z. Rocha, Cláudio Teodoro de Souza et al. · 2014 · Nature Communications
  6. Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy
    Kawai, Hironari, Osawa, Yosuke, Matsuda, Michitaka, Tsunoda, Tomoyuki, Yanagida, Keisuke, Hishikawa, Daisuke, Okawara, Miku, Sakamoto, Yuzuru, Shimagaki, Tomonari, Tsutsui, Yuriko et al. · 2022 · Hepatology
  7. Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages
    Yuquan Xiong, Hyeuk Jong Lee, Boubacar Mariko, Yi-Chien Lu, Andrew J. Dannenberg, Abigail S. Haka, Frederick R. Maxfield, Eric Camerer, Richard L. Proia, Timothy Hla · 2013 · Journal of Biological Chemistry
  8. Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues
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  9. Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease
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  10. S1PR1 as a Novel Promising Therapeutic Target in Cancer Therapy
    N. Rostami, A. Nikkhoo, Amir Ajoolabady, G. Azizi, M. Hojjat-Farsangi, G. Ghalamfarsa, B. Yousefi, M. Yousefi, Farhad Jadidi-Niaragh · 2019 · Molecular Diagnosis & Therapy
  11. MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells
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  12. Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis
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  13. FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment
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  14. Recent advances in the role of sphingosine 1‐phosphate in cancer
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  15. STAT3 in hepatocellular carcinoma: new perspectives
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  16. STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.
    Andrew V. Nguyen, Yuan-Yuan Wu, E. Lin · 2014 · World Journal of Gastroenterology
  17. FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes
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  18. Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment
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  19. S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways
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  20. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
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  21. The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses
    Carole A. Oskeritzian, Nitai C. Hait, Piper Wedman, Alena P. Chumanevich, Elizabeth Motunrayo Kolawole, Megan M. Price, Yves T. Falanga, Kuzhuvelil B. Harikumar, John Jake Ryan, Sheldon Milstien et al. · 2014 · Journal of Allergy and Clinical Immunology
  22. Lymph Nodes and Cancer Metastasis: New Perspectives on the Role of Intranodal Lymphatic Sinuses
    Rui‐Cheng Ji · 2016 · International Journal of Molecular Sciences
  23. De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer
    Naser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Young Lee, Heidi L. Weiss et al. · 2018 · Molecular Cancer Research
  24. Colon Cancer and Perturbations of the Sphingolipid Metabolism
    Miroslav Machala, Jiřina Procházková, Jiřina Hofmanová, Lucie Králíková, Josef Slavík, Zuzana Tylichová, Petra Ovesná, Alois Kozubı́k, Jan Vondráček · 2019 · International Journal of Molecular Sciences
  25. An oncogenic role for sphingosine kinase 2
    Heidi Anne Neubauer, Duyen Pham, Julia R. Zebol, Paul A.B. Moretti, Amanda L. Peterson, Tamara M. Leclercq, Huasheng Chan, Jason A. Powell, Melissa R. Pitman, Michael Susithiran Samuel et al. · 2016 · Oncotarget
  26. TRIM14 promotes colorectal cancer cell migration and invasion through the SPHK1/STAT3 pathway
    Zhonghai Jin, Hongguang Li, Xiaofei Hong, Guangrong Ying, Xiaofeng Lu, Li-Lei Zhuang, Shenbao Wu · 2018 · Cancer Cell International
  27. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression
    Renata Feuerborn, Susen Becker, Francesco Potì, Petra Nagel, Martin F. Brodde, Harmut Schmidt, Christina Christoffersen, Uta Ceglarek, Ralph Burkhardt, Jerzy–Roch Nofer · 2016 · Atherosclerosis
  28. Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
    Loubna Abdel Hadi, Clara Di Vito, Laura Riboni · 2016 · Mediators of Inflammation
  29. The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives
    Alexandra Lucaciu, Robert Brunkhorst, Josef M. Pfeilschifter, Waltraud Pfeilschifter, Julien Subburayalu · 2020 · Cells
  30. Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
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  31. mPGES-1 and ALOX5/-15 in tumor-associated macrophages
    Andreas Weigert, Elisabeth Strack, Ryan G. Snodgrass, Bernhard Brüne · 2018 · Cancer and Metastasis Reviews
  32. STAT3 in Epithelial Cells Regulates Inflammation and Tumor Progression to Malignant State in Colon
    Andrew Nguyen, Yuanyuan Wu, Qiang Liu, Donghai Wang, Stephanie A. Nguyen, Ricky Loh, Joey Pang, Kenneth A. Friedman, Amos Orlofsky, Leonard H. Augenlicht et al. · 2013 · Neoplasia
  33. Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer
    Jessica A. Beach, Paul-Joseph P. Aspuria, Dong‐Joo Cheon, Kate Lawrenson, Hasmik Agadjanian, Christine Walsh, Beth Y. Karlan, Sandra Oršulić · 2015 · Oncotarget
  34. GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis
    Yangmeng Wang, Hongxiu Ning, Fangli Ren, Yuanjiang Zhang, Yu Rong, Yinyin Wang, Fuqin Su, Chenguang Cai, Zhe Hu Jin, Zhiyong Li et al. · 2014 · Molecular Cell
  35. Sphingosine‐1‐phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans
    Wei‐Ching Huang, Jie Liang, Masayuki Nagahashi, Dorit Avni, Akimitsu Yamada, Michael W. Maceyka, Aaron R. Wolen, Tomasz Kordula, Sheldon Milstien, Kazuaki Takabe et al. · 2016 · The FASEB Journal
  36. Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis
    Mel Pilar Espaillat, Richard R. Kew, Lina Marie Obeid · 2016 · Advances in Biological Regulation
  37. Sphingolipids in Obesity and Correlated Co-Morbidities: The Contribution of Gender, Age and Environment
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  38. Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple‐Negative Subtype of Breast Cancer Patients
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  39. Advances and challenges in the molecular biology and treatment of glioblastoma-is there any hope for the future?
    Ignacio Véliz, Yong Loo, O. Castillo, Niki Karachaliou, Olga Nigro, Rafael Rosell · 2015 · Europe PMC (PubMed Central)
  40. Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis
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  41. Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells
    Decai Wang, Shengbo Han, Guozheng Lv, Yuhang Hu, Wenfeng Zhuo, Zhu Zeng, Jiang Tang, Yan Huang, Fan Wang, Jie Wang et al. · 2023 · Gastroenterology
  42. Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease
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  43. Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway
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  44. Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis
    Jin Wu, Yiting Luo, Yan Shen, Yuyao Hu, Fangyuan Zhu, Jiaqian Wu, Yingchao Liu · 2022 · Drug Design Development and Therapy
  45. Roles of tumor suppressors in regulating tumor-associated inflammation
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  46. Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6
    Sei-ichiro Ohkura, Soichiro Usui, Shinichiro Takashima, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Yutaka Inagaki, Naotoshi Sugimoto, Teppei Kitano, Masayuki Takamura et al. · 2017 · PLoS ONE
  47. Genomic characterization of colitis-associated colorectal cancer
    Hitoshi Kameyama, Masayuki Nagahashi, Yoshifumi Shimada, Yosuke Tajima, Hiroshi Ichikawa, Masato Nakano, Jun Sakata, Takashi Kobayashi, Sumana Narayanan, Kazuaki Takabe et al. · 2018 · World Journal of Surgical Oncology
  48. S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer
    Julie Deane Saba, Émilie Degagné · 2014 · Clinical and Experimental Gastroenterology
  49. Catestatin decreases macrophage function in two mouse models of experimental colitis.
    M. F. Rabbi, Benoit Labis, M. Metz-Boutigue, C. Bernstein, J. Ghia · 2014 · Biochemical Pharmacology
  50. Regulation of EMT by STAT3 in gastrointestinal cancer (Review)
    Bo Li, Chen Huang · 2017 · International Journal of Oncology
  51. Sphingolipids as mediators of inflammation and novel therapeutic target in inflammatory bowel disease
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  52. Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
    Checa, Antonio, Xu, Ning, Sar, Daniel G., Haeggström, Jesper Z., Ståhle, Mona, Wheelock, Craig E. · 2015 · Scientific Reports
  53. Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence
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  54. Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer
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  55. FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice
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  56. Lipid Phosphate Phosphatases and Cancer
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  57. The signaling lipid sphingosine 1-phosphate regulates mechanical pain
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  58. Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis‐associated colon cancer
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  60. S1PR1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating STAT3 pathway
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  61. How cancer cells remodel lipid metabolism: strategies targeting transcription factors
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  66. Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism
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  67. Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide
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  69. The role of sphingosine 1-phosphate in inflammation and cancer
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  70. Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells
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  73. Stat3
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  76. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire.
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  77. Sphingosine‐1‐phosphate receptor 1 mediates elevated IL‐6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease
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  78. Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer
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  83. Sphingolipid-mediated calcium signaling and its pathological effects
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  86. Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation
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  87. Sphingosine-1-phosphate and estrogen signaling in breast cancer
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  92. Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease
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  98. Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain
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  99. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2
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