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In Vivo RNAi Screen for BMI1 Targets Identifies TGF-β/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis

Gargiulo, Gaetano, Cesaroni, Matteo, Serresi, Michela, de Vries, Nienke, Hulsman, Danielle, Bruggeman, Sophia W., Lancini, Cesare, van Lohuizen, Maarten·2013·Cancer Cell
DOI 10.1016/j.ccr.2013.03.030
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Abstract

In mouse and human neural progenitor and glioblastoma "stem-like" cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq with in vivo RNAi screening. We discovered that Bmi1 is important in the cellular response to the transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) and endoplasmic reticulum (ER) stress pathways, in part converging on the Atf3 transcriptional repressor. We show that Atf3 is a tumor-suppressor gene inactivated in human glioblastoma multiforme together with Cbx7 and a few other candidates. Acting downstream of the ER stress and BMP pathways, ATF3 binds to cell-type-specific accessible chromatin preloaded with AP1 and participates in the inhibition of critical oncogenic networks. Our data support the feasibility of combining ChIP-seq and RNAi screens in solid tumors and highlight multiple p16(INK4a)/p19(ARF)-independent functions for Bmi1 in development and cancer.

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Research works printed but not linked: 44

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Metadata

Authors
Gargiulo, G., Cesaroni, M., Serresi, M., de Vries, N., Hulsman, D., Bruggeman, S. W., Lancini, C., & van Lohuizen, M.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2013-05
Volume
23
Issue
5
Pages
660-676
ISSN
1535-6108
DOI
10.1016/j.ccr.2013.03.030
Cited by
176
References
7
Language
en
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