ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Genome engineering using the CRISPR-Cas9 system

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Serine, glycine and one-carbon units: cancer metabolism in full circle

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Modification of Enhancer Chromatin: What, How, and Why?

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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Serine and one-carbon metabolism in cancer

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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

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ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

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The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis

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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4

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NRF2 regulates serine biosynthesis in non–small cell lung cancer

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Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

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ATF3 and stress responses.

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Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

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ATF4-dependent transcription mediates signaling of amino acid limitation

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Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

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Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

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The importance of serine metabolism in cancer

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ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

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Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition

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Opposing roles for calcineurin and ATF3 in squamous skin cancer

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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

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The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

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mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

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Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

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Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice

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Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

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Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

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Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-3

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A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development

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In Vivo RNAi Screen for BMI1 Targets Identifies TGF-β/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis

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Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

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KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

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p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

Ou, Y., Wang, S.-J., Jiang, L., Zheng, B., & Gu, W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616359 · Cited by 154 · see citing works

gadd153/Chop10 , a Potential Target Gene of the Transcriptional Repressor ATF3

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Dichotomous engagement of HDAC3 activity governs inflammatory responses

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Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53

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ATF3 Suppresses Metastasis of Bladder Cancer by Regulating Gelsolin-Mediated Remodeling of the Actin Cytoskeleton

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Transcription factor ATF3 links host adaptive response to breast cancer metastasis

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Amino Acid Deprivation and Endoplasmic Reticulum Stress Induce Expression of Multiple Activating Transcription Factor-3 mRNA Species That, When Overexpressed in HepG2 Cells, Modulate Transcription by the Human Asparagine Synthetase Promoter

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The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation

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Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway

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Transcriptional Autorepression of the Stress-inducible GeneATF3

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p300 Modulates ATF4 Stability and Transcriptional Activity Independently of Its Acetyltransferase Domain

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NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3 , C/EBP and ATF3

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Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression

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Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3

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KAI1 Gene Is Engaged in NDRG1 Gene-mediated Metastasis Suppression through the ATF3-NFκB Complex in Human Prostate Cancer

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Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

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ATF3 Regulates the Stability of p53: A Link to Cancer

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Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

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ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

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The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?

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MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3

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Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

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The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

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The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor

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Competitive ubiquitination activates the tumor suppressor p53

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Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

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NSAID‐activated gene‐1 as a molecular target for capsaicin‐induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta, and ATF3

Lee, S., Krisanapun, C., & Baek, S. J. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.928.11 · Cited by 39 · see citing works

Epitope tagging of endogenous genes in diverse human cell lines

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Emerging roles of ATF3 in the suppression of prostate cancer

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Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5+CK8+ epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H.-F., Zhang, J., Hai, T., Cowell, J. K., & Yan, C. (2015) · Oncogene · doi:10.1038/onc.2015.417 · Cited by 19 · see citing works

Metabolic reprogramming, sensing, and cancer therapy

Mao, Y., Xia, Z., Xia, W., & Jiang, P. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115064 · Cited by 168 · see citing works

The integrated stress response in metabolic adaptation

Ryoo, H. D. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107151 · Cited by 120 · see citing works

SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

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Regulatory mechanisms of one-carbon metabolism enzymes

Petrova, B., Maynard, A. G., Wang, P., & Kanarek, N. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105457 · Cited by 103 · see citing works

Serine signaling governs metabolic homeostasis and health

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AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

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PHGDH: a novel therapeutic target in cancer

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NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization

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Cycling back to folate metabolism in cancer

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Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila

Kosakamoto, H., Okamoto, N., Aikawa, H., Sugiura, Y., Suematsu, M., Niwa, R., Miura, M., & Obata, F. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00608-7 · Cited by 46 · see citing works

Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth

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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model

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PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress

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Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies

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Serine Metabolic Reprogramming in Tumorigenesis, Tumor Immunity, and Clinical Treatment

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Activating transcription factor 4: a regulator of stress response in human cancers

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N6-Methyladenosine modification activates the serine synthesis pathway to mediate therapeutic resistance in liver cancer

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Target enzymes in serine‐glycine‐one‐carbon metabolic pathway for cancer therapy

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Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity

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A comprehensive review on signaling attributes of serine and serine metabolism in health and disease

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The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment

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Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer

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Epigenetic developmental mechanisms underlying sex differences in cancer

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ASCT2 is a major contributor to serine uptake in cancer cells

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1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

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Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus

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20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells

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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction

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The landscape of ATF3 in tumors: Metabolism, expression regulation, therapy approach, and open concerns

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Amino acids metabolism: a potential target for cancer treatment

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MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury

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Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

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Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Lü, X., Zhong, L., Lindell, E., Veanes, M., Guo, J., Zhao, M., Salehi, M., Swartling, F. J., Chen, X., Sjöblom, T., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06204-1 · Cited by 13 · see citing works

TFTG: A comprehensive database for human transcription factors and their targets

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Unleashing metabolic power for axonal regeneration

Yang, X.-Y., & Zhou, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.001 · Cited by 12 · see citing works

The stress-responsive gene ATF3 drives fibroblast activation and collagen production through transcriptionally activating TGF-β receptor Ⅱ in skin wound healing

Luo, P., Wang, F., Li, J., Liu, G., Qin, X., Yan, B., Cao, X., Liu, B., Wang, Y., Wu, G., et al. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110134 · Cited by 12 · see citing works

Knockdown of ERN1 disturbs the expression of phosphoserine aminotransferase 1 and related genes in glioblastoma cells

Minchenko, О. H., Sliusar, M. Y., Khikhlo, Y. P., Halkin, O. V., Viletska, Y. M., Khita, O. O., & Minchenko, D. O. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110104 · Cited by 11 · see citing works

Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance

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TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine

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MicroRNA regulation of the serine synthesis pathway in endocrine-resistant breast cancer cells

Petri, B. J., Piell, K. M., Wilt, A. E., Howser, A. D., Winkler, L., Whitworth, M. R., Valdés, B., Lehman, N. L., Clem, B. F., & Klinge, C. M. (2023) · Endocrine Related Cancer · doi:10.1530/erc-23-0148 · Cited by 15 · see citing works

Cis-Regulatory Elements in Mammals

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Metabolism and mRNA translation: a nexus of cancer plasticity

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A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells

Eduardo, M. B., Cottone, G., McCloskey, C. W., Liu, S., Palma, F. R., Zappia, M. P., Islam, A. B. M. M. K., Gao, P., Setya, J., Dennis, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads9182 · Cited by 11 · see citing works

20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells

Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease

Garg, A., Blume, S. Y., Huynh, H., Barrios, A. M., Karabulut, O. O., Zhao, Q., Midha, A. D., Turner, A. W., Resnick, B. V., Chen, X., et al. (2026) · Cell · doi:10.1016/j.cell.2026.01.022 · Cited by 9 · see citing works

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Minchenko, О. H., Sliusar, M. Y., Khita, O. O., Minchenko, D. O., Viletska, Y. M., Halkin, O. V., Levadna, L. O., Cherednychenko, A. A., & Khikhlo, Y. P. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0010 · Cited by 9 · see citing works

The “serine code” of metabolic reprogramming: multidimensional roles of the serine synthesis pathway in tumors and novel breakthroughs for targeted therapy

Su, P., Yang, Y., & Zheng, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1779543 · Cited by 8 · see citing works

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions

Wang, H., Fan, M., Liu, S., Qu, M., Hou, X., Hou, J., Xu, Y., Shang, X., Liu, C., He, M., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-13304-4 · Cited by 8 · see citing works

Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies

Lin, Z., Chang, C., Zhao, S., Fang, L., & Wang, P. (2025) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2025.0115 · Cited by 8 · see citing works

NRF2-SOX4 complex regulates PSPH in hepatocellular carcinoma and modulates M2 macrophage differentiation

Tsai, C., Yu, M., Lee, Y., Feng, K.-C., Wu, C.-H., Li, Y.-C., Cheng, M., Lin, S., Huang, S.-F., Lin, T., et al. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00951-3 · Cited by 6 · see citing works

Targeting serine synthesis pathway to reverse paclitaxel resistance in NSCLC with combination of paclitaxel and anlotinib

Yu, M., Hong, Y., Pan, Q., Zheng, P., He, Y., Zhu, W., Xu, S., & Lv, Q. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03627-w · Cited by 6 · see citing works

Afidopyropen suppresses silkworm growth and vitality by affecting carbohydrate metabolism and immune function

Wei, E., He, P., Wang, R., Xu, S., Zhang, Y., Wang, Q., Tang, X., & Shen, Z. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105568 · Cited by 6 · see citing works

ASCT2 is the primary serine transporter in cancer cellsPreprint

Conger, K. O., Chidley, C., Ozgurses, M., Zhao, H., Kim, Y., Semina, S. E., Burns, P. A., Rawat, V., Sheldon, R., Ben-Sahra, I., et al. (2023) · bioRxiv · doi:10.1101/2023.10.09.561530 · Cited by 5 · see citing works

PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer

Hao, L., Li, B., Lü, S., An, Z.-C., Yin, Z.-Y., Du, Z., & Wang, H.-Q. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-025-01205-y · Cited by 5 · see citing works

Targeting BACH1/PSPH axis suppresses bladder cancer progression and gemcitabine resistance by downregulating S100A2 expression

Ma, T., Ma, J., Wang, Y., Kui, X., Liu, J., Han, C., Wei, W., Lin, Z., & Song, X. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117182 · Cited by 5 · see citing works

Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells

Bonanomi, M., Mallia, S., Scalise, M., Aramini, T., Baldassari, F., Brivio, E., Conte, F., Dico, A. L., Bonas, M., Porro, D., et al. (2025) · Antioxidants · doi:10.3390/antiox14070833 · Cited by 4 · see citing works

Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation

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Large-scale single-cell analysis and in silico perturbation reveal dynamic evolution of HCC: from initiation to therapeutic targeting

Xia, P., Shuang, S., Fu, D., Liu, L., Yang, D., Guo, Y., Tian, Y., Ji, P., Yuan, X., Tian, Y., et al. (2026) · npj Precision Oncology · doi:10.1038/s41698-026-01307-2 · Cited by 4 · see citing works

Amino Acids Supplementation in Cancer: What Do We Feed, the Patient or the Tumor?

Corsetti, G., Pasini, E., Romano, C., & Dioguardi, F. (2025) · Nutrients · doi:10.3390/nu17172813 · Cited by 4 · see citing works

Increased dietary protein rather than fiber supports key metabolic and intestinal tissue functions in pigs, without increasing postweaning diarrhea

Diether, N. E., Kommadath, A., Fouhse, J. M., Zijlstra, R. T., Stothard, P., & Willing, B. P. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00146.2024 · Cited by 4 · see citing works

Chronic nanoplastics exposure drives lung cancer progression through ATF3/PCK2 axis-mediated rewiring of truncated gluconeogenesis

Li, Q., Meng, W., Xie, C., Wang, F., Deng, Y., Chen, K., Li, Y., Li, Y. H., Wen, Y., Zhu, J., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140764 · Cited by 3 · see citing works

Metabolic remodeling and immune evasion in glioblastoma: a focus on serine and lipid networks

Jiang, D., Wang, C., Zhao, Y., & Li, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1676560 · Cited by 3 · see citing works

Metabolic Vulnerabilities as a Therapeutic Target in Breast Cancer

Guo, S., & Addison, C. (2026) · Current Oncology · doi:10.3390/curroncol33020129 · Cited by 4 · see citing works

Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer

Chen, S., Chang, K., Lin, W.-Y., Hsu, S.-Y., Sung, H., Lin, Y.-H., Feng, T., Hou, C., & Juang, H. (2024) · Biomedical Journal · doi:10.1016/j.bj.2024.100756 · Cited by 3 · see citing works

Possible Metabolic Remodeling based on de novo Biosynthesis of L-serine in Se-Subtoxic or -Deficient Mammals

Wang, J., Zhang, X., Zhan, S., Han, F., Wang, Q., Liu, Y., & Huang, Z. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.10.041 · Cited by 3 · see citing works

Hydroxymethyltransferase 2 promotes the development of glioblastoma by mediating WTAP regulation of PTEN N6-methyladenosine modification

Wang, M., Sun, G., Fan, Y., Sima, G., Sun, X., Qiu, T., & Li, X. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01621-x · Cited by 3 · see citing works

Drivers of de novo Serine/Glycine synthesis in acute leukemia

Verstraete, P., Keersmaecker, K. D., & Kampen, K. R. (2023) · FEBS Letters · doi:10.1002/1873-3468.14700 · Cited by 3 · see citing works

Suppression of cisplatin induced ATF3 expression and apoptosis by BK polyomavirus and its encoded microRNA in bladder cancer cells

Li, Y., Chen, Y., Wang, J.-W., Wu, H.-H., Hsu, H., Ho, D., Yang, C., & Tian, Y. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118032 · Cited by 2 · see citing works

The oncoprotein DEK controls growth‐regulated gene expression by enhancing the DNA ‐binding activity of basic leucine zipper transcription factors

Hashimoto, T., Saito, S., Ohata, M., & Okuwaki, M. (2025) · FEBS Journal · doi:10.1111/febs.70124 · Cited by 2 · see citing works

PSAT1 knockdown mediated VDAC1 oligomerization promotes ferroptosis and suppresses cell proliferation in esophageal squamous cell carcinoma

Ren, R., Fan, T., Li, Y., Li, C., Jin, F., Gao, H. Y., Wang, X., Xu, Y., Li, X., Li, S., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148112 · Cited by 2 · see citing works

The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells

Minchenko, О. H., Kulish, Y. V., Viletska, Y. M., Khita, O. O., Rudnytska, O. V., Kozynkevych, H. E., & Minchenko, D. O. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0029 · Cited by 2 · see citing works

1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cellsPreprint

Cordes, T., Kuna, R. S., McGregor, G. H., Khare, S., Gengatharan, J. M., Muthusamy, T., & Metallo, C. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.19.476986 · Cited by 2 · see citing works

Regulation of RNA methylation by therapy treatment, promotes tumor survivalPreprint

Bukhari, S. I. A., Truesdell, S. S., Datta, C., Choudhury, P., Wu, K. Q., Shrestha, J., Maharjan, R., Plotsker, E., Elased, R. K., Laisa, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.19.540602 · Cited by 2 · see citing works

Chlamydia trachomatis L2 434/Bu readily activates glycolysis under hypoxia for efficient metabolism

Li, R., Zhang, S., Otsuguro, S., Nagao, M., Matsuda, A., Thapa, J., Okubo, T., Maenaka, K., Higashi, H., & Yamaguchi, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150461 · Cited by 1 · see citing works

The serine synthesis pathway is indispensable for glioblastoma growth and malignancy

Yun, H. J., Liu, R. R., & Lee, J. (2025) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-025-00247-1 · Cited by 1 · see citing works

OGT-Mediated O-GlcNAcylation of ATF3 Transcriptionally Activates ACSL1 to Aggravate Ferroptosis in Severe Acute Pancreatitis: ATF3 O-GlcNAcylation Promotes SAP Ferroptosis

Weng, X., Luo, J., Xu, J., Huang, S., Hu, J., & Tang, Z. (2025) · Pancreas · doi:10.1097/mpa.0000000000002613 · Cited by 1 · see citing works

Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia

Daniel, M. M., & Andwey, G. H. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71007 · Cited by 1 · see citing works

Targeting FOXM1/PSAT1 axis by Brusatol inhibits lung cancer malignant progression

Ou, S., Wang, X., Sun, Y., Liang, Y., Bai, J., Han, C., & Song, J. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156365 · Cited by 1 · see citing works

PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability

Zhou, X., Zhao, M., Cao, Y., Zhou, X., & Wang, K. (2026) · Cancer Medicine · doi:10.1002/cam4.71780 · Cited by 1 · see citing works

ATF3 in metabolic homeostasis and vascular disease: integrating bibliometric evidence with therapeutic potential

Lin, H., Chen, H.-H., Lin, Y.-P., Li, H.-F., Lin, J.-H., Lee, K., & Tseng, T. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00006.2026 · Cited by 1 · see citing works

L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated glutathione degradation in hepatocellular carcinoma

Xi, C., Pang, J., Oliaeimotlagh, M., Mao, R., Zhi, W., Jones, K., Hu, T., Shi, H., Ande, S., Horuzsko, A., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09052-x · Cited by 1 · see citing works

CCDC86-BHLHE40-ATF3 axis promotes aerobic glycolysis and tumor development in glioma

Liu, J., Du, D., Huang, Y., Tian, J., Wang, X., Chen, L., & Wang, F. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101643 · Cited by 1 · see citing works

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cellsPreprint

Eduardo, M. B., Cottone, G., McCloskey, C. W., Liu, S., Zappia, M. P., Benevolenskaya, E. V., Islam, A. B. M. M. K., Frolov, M. V., Palma, F. R., Gao, P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.21.581404 · Cited by 1 · see citing works

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AMLPreprint

Sinanidis, I., Tsakiroglou, P., Dubner, B. G., Foertsch, R., Gondek, J., Choi, I., Paun, B. C., Zhao, L., Ghiaur, G., & Dalton, W. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.13.651470 · Cited by 1 · see citing works

Untersuchungen zum Serin- und Glycin-Metabolismus und der Phosphoserin-Aminotransferase 1 in der Modellzelllinie P493-6

Harms, W. (2023) · doi:10.53846/goediss-10260

Mathematical modelling of carbohydrate and protein metabolism in muscle

Alharbi, B. M., Williams, H. E., Parr, T., Brameld, J. M., Fallaize, C. J., & Wattis, J. A. D. (2025) · Mathematical Biosciences · doi:10.1016/j.mbs.2025.109455

Interplay Between Cellular Stress Mechanisms And Immune Responses In Restricting Zika Virus Infection

Badu, P. (2024) · doi:10.54014/2q9t-fz12

Medium-Chain Fatty Acid exposure in non-transformed mammary glands leads to pro-tumorigenic alterations associated with agingPreprint

Eduardo, M. B., Islam, A. B. M. M. K., McCloskey, C. W., Zappia, M. P., Frolov, M. V., Khokha, R., Benevolenskaya, E. V., Khan, S. A., & Clare, S. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.01.679891

Serine metabolism reprogramming in cancer: a multi-tiered regulatory framework

Yuan, Y., Wang, K., Jin, Y., & Han, T. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025188

Additional file 1 of AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

Yun, H. J., Li, M., Guo, D., Jeon, S. M., Park, S. H., Lim, J. S., Lee, S. B., Liu, R., Du, L., Kim, S.-H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24819674

MiR-181a-5p/CDK6 axis attenuates cell proliferation, migration and glycolytic reprogramming in oral squamous cell carcinoma

Gao, J., Yang, Y., Chang, X., Wang, X., Zhang, Z., Shi, S., Liu, Y., Su, J., Chen, Z., Sun, R., et al. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04171-z

Serine Hydroxymethyltransferase in Cancer Cells

Гаврилюк, Л. А. (2025) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750824601371

Rewiring of de novo serine synthesis supports tumorigenesis under deficiency of TET2

Zheng, K., Rao, K., Lü, X., Yang, M., Wu, H., Ai, Z., & He, J. (2026) · British Journal of Cancer · doi:10.1038/s41416-026-03526-7

Comprehensive analysis of the association between perfluorooctanoic acid exposure and osteosarcoma progression

Dong, Y., Zheng, J., Dong, X., Lv, Y., Xu, Z., Ye, C., Zhu, S., Dong, H., & Lv, Y. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116274

Metabolic targeting of cyst(e)ine enhances carboplatin responsiveness in ovarian cancer

Yoon, I., Oh, S., Park, S. Y., Park, J., Jang, H., Park, E., You, K. A., Kim, K., Hwang, S., Kim, H. Y., et al. (2026) · Cancer & Metabolism · doi:10.1186/s40170-026-00450-5

The Dysregulation of the Integrated Stress Response in Leukemic Stem Cells as a Marker of Treatment Sensitivity in Acute Myeloid Leukemia

Dutti, G. B., Mangialardi, K., Rasola, S., Sebastio, L., Tarantini, F., Cumbo, C., Anelli, L., Zagaria, A., Coccaro, N., Minervini, A., et al. (2026) · Genes · doi:10.3390/genes17080954

PHGDH: metabolic enzyme or signaling hub? From broad-spectrum inhibition toward context-adapted therapeutic targeting

Sun, C., Wu, S., Li, Z., Huang, C., & Wu, D. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118376

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

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