The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
Open accessAbstract
Since Notch phenotypes in Drosophila melanogaster were identified 100 years, Notch signaling has been extensively characterized as a regulator of cell fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this Perspective, we discuss the pro-tumorigenic and tumor suppressive functions of Notch signaling and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers.
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Cites
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Cited by
Small-cell lung cancer: what we know, what we need to know and the path forward
Gazdar, A. F., Bunn, P. A., & Minna, J. D. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.87 · Cited by 904
Notch Signaling in the Tumor Microenvironment
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NOTCH1 mediates a switch between two distinct secretomes during senescence
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Self-citation
Metadata
- Authors
- Ntziachristos, P., Lim, J. S., Sage, J., & Aifantis, I.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 25
- Issue
- 3
- Pages
- 318-334
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2088720735
- Cited by
- 374
- References
- 22
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ntziachristos, P., Lim, J. S., Sage, J., & Aifantis, I. (2014). From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling. Cancer Cell. https://doi.org/10.1016/j.ccr.2014.02.018
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