The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Notch Signaling in the Tumor Microenvironment
Open accessAbstract
The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed cell. However, it is now clear that cancer progression and metastasis depend on the bidirectional interactions between cancer cells and their environment, forming the tumor microenvironment (TME). These interactions are mediated and constantly evolve through paracrine and juxtacrine signaling. In this review, we discuss how Notch signaling takes an important part in regulating the crosstalk between the different compartments of the TME. We also address the consequences of the Notch-TME involvement from a therapeutic perspective.
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Cites
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994
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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
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Cited by
Targeting cancer stem cell pathways for cancer therapy
Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,906
Fu, T., Dai, L.-J., Wu, S.-Y., Xiao, Y., Ma, D., Jiang, Y.-Z., & Shao, Z.-M. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01103-4 · Cited by 480
Stiff matrix induces exosome secretion to promote tumour growth
Wu, B., Liu, D.-A., Guan, L., Myint, P. K., Chin, L., Dang, H., Xu, Y., Ren, J., Li, T., Yu, Z., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01092-1 · Cited by 240
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“18,19 With the development of tumor immunity, the immune context of the TME, i.e., TIME, has been proven to play a decisive role in carcinogenesis, tumor progression, metastasis, recurrence, and potential therapeutic targets making it being the focus of our review.”
BackgroundFang, Z., Ruan, B., Liu, J., Duan, J., Yue, Z., Song, P., Xu, H., Ding, J., Xu, C., Dou, G., et al. (2022) · Hepatology · doi:10.1002/hep.32332 · Cited by 91
Metadata
- Authors
- Meurette, O., & Mehlen, P.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 34
- Issue
- 4
- Pages
- 536-548
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2888518905
- Cited by
- 678
- References
- 107
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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