The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression
Open accessAbstract
SUMMARY Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that recapitulates the histology, gene expression, and microenvironment found in human disease. Lkb1;Pten null (LP) tumors expressed the squamous markers KRT5, p63 and SOX2, and transcriptionally resembled the basal subtype of human SCC. In contrast to mouse adenocarcinomas, the LP tumors contained immune populations enriched for tumor-associated neutrophils. SCA1+NGFR+ fractions were enriched for tumor-propagating cells (TPCs) that could serially transplant the disease in orthotopic assays. TPCs in the LP model and NGFR+ cells in human SCCs highly expressed Pd-ligand-1 (PD-L1), suggesting a mechanism of immune escape for TPCs.
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Cites
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Topalian, S. L., Taube, J. M., Anders, R. A., & Pardoll, D. M. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.36 · Cited by 2,733
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Metadata
- Authors
- Xu, C., Fillmore, C. M., Koyama, S., Wu, H., Zhao, Y., Chen, Z., Herter-Sprie, G. S., Akbay, E. A., Tchaicha, J. H., Altabef, A., Reibel, J. B., Walton, Z., Ji, H., Watanabe, H., Jänne, P. A., Castrillon, D. H., Rustgi, A. K., Bass, A. J., Freeman, G. J., Padera, R. F., Dranoff, G., Hammerman, P. S., Kim, C. F., & Wong, K.-K.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 25
- Issue
- 5
- Pages
- 590-604
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2053627244
- Cited by
- 391
- References
- 44
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xu, C., Fillmore, C. M., Koyama, S., Wu, H., Zhao, Y., Chen, Z., Herter-Sprie, G. S., Akbay, E. A., Tchaicha, J. H., Altabef, A., Reibel, J. B., Walton, Z., Ji, H., Watanabe, H., Jänne, P. A., Castrillon, D. H., Rustgi, A. K., Bass, A. J., Freeman, G. J., . . . Wong, K.-K. (2014). Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression. Cancer Cell. https://doi.org/10.1016/j.ccr.2014.03.033
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
