Cited by 114Microtubule and mitosis dynamicsCancer Treatment and PharmacologySynthesis and biological activity

Microtubule-depolymerizing kinesins

Wordeman, Linda·2005·Current Opinion in Cell Biology

Abstract

The fact that some kinesin-related proteins can destabilize microtubules is now a well-established fact. However, the contribution that these kinesins make to cellular function is just coming into focus. Key structural and kinetic studies on the mechanism of microtubule depolymerization by these kinesins have provided a framework for understanding their cellular regulation and function. Completion of some of the genome sequences and recent technological advances enabling the rapid depletion of cellular proteins in metazoans have clarified the functional role and level of cooperation between members of the depolymerizing kinesin families. Recent studies utilizing these technologies have revealed how these kinesins play an integral role in the mechanics of mitotic spindle assembly, chromosome segregation and the shaping of connections in the brain.

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Crossref · 10.1016/j.ceb.2004.12.003

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Authors
Wordeman, L.
Affiliations
University of Washington (US)
Corresponding author
Wordeman, Linda
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2005-02
Volume
17
Issue
1
Pages
82-88
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2072333621
Cited by
114
References
57
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 8
FWCI
0.50
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (R01GM069429, GM69429)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
Keywords
kinesin, microtubule depolymerization, microtubule destabilization, mitotic spindle assembly, chromosome segregation
MeSH terms
Adenosine Triphosphate, Adenylyl Imidodiphosphate, Animals, Humans, Hydrolysis, Kinetics, Microtubules, Mitosis, Spindle Apparatus, Models, Biological, Neurons, Kinesins

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