Microtubule-depolymerizing kinesins
Abstract
The fact that some kinesin-related proteins can destabilize microtubules is now a well-established fact. However, the contribution that these kinesins make to cellular function is just coming into focus. Key structural and kinetic studies on the mechanism of microtubule depolymerization by these kinesins have provided a framework for understanding their cellular regulation and function. Completion of some of the genome sequences and recent technological advances enabling the rapid depletion of cellular proteins in metazoans have clarified the functional role and level of cooperation between members of the depolymerizing kinesin families. Recent studies utilizing these technologies have revealed how these kinesins play an integral role in the mechanics of mitotic spindle assembly, chromosome segregation and the shaping of connections in the brain.
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MCAK is a potent microtubule depolymerase.
“The kinesin-13 family member mitotic centromere-associated kinesin (MCAK) is a potent microtubule depolymerase [1-4].”
From In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends (2010) · cites this paper as [2]
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- Authors
- Wordeman, L.
- Affiliations
- University of Washington (US)
- Corresponding author
- Wordeman, Linda
- ORCID
- Wordeman, Linda
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 17
- Issue
- 1
- Pages
- 82-88
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2072333621
- Cited by
- 114
- References
- 57
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM069429, GM69429)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- kinesin, microtubule depolymerization, microtubule destabilization, mitotic spindle assembly, chromosome segregation
- MeSH terms
- Adenosine Triphosphate, Adenylyl Imidodiphosphate, Animals, Humans, Hydrolysis, Kinetics, Microtubules, Mitosis, Spindle Apparatus, Models, Biological, Neurons, Kinesins
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