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Glucose metabolism and cancer
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Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Metformin and reduced risk of cancer in diabetic patients
Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005) · BMJ · doi:10.1136/bmj.38415.708634.f7 · Cited by 2,388
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.022 · Cited by 2,108
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019
Self-citationThe Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950
Self-citationShaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797
Self-citationp53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650
Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2904 · Cited by 1,454
Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967
Majumder, P. K., Febbo, P. G., Bikoff, R., Berger, R., Xue, Q., McMahon, L. M., Manola, J., Brugarolas, J., McDonnell, T. J., Golub, T. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1052 · Cited by 964
Bowker, S. L., Majumdar, S. R., Veugelers, P., & Johnson, J. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1558 · Cited by 933
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
Kondo, K., Klco, J., Nakamura, E., Lechpammer, M., & Kaelin, W. G. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00043-0 · Cited by 761
Glycolytic Enzymes Can Modulate Cellular Life Span
Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
Thomas, G. V., Tran, C., Mellinghoff, I. K., Welsbie, D. S., Chan, E., Fueger, B., Czernin, J., & Sawyers, C. L. (2006) · Nature Medicine · doi:10.1038/nm1337 · Cited by 604
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
Hahn-Windgassen, A., Nogueira, V., Chen, C.-C., Skeen, J. E., Sonenberg, N., & Hay, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502876200 · Cited by 539
AMPK, the metabolic syndrome and cancer
Luo, Z., Saha, A. K., Xiang, X., & Ruderman, N. B. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.011 · Cited by 426
Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., et al. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.007 · Cited by 402
A role for mitochondrial enzymes in inherited neoplasia and beyond
Eng, C., Kiuru, M., Fernandez, M. J., & Aaltonen, L. A. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1013 · Cited by 392
Buzzai, M., Bauer, D. E., Jones, R. G., DeBerardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208622 · Cited by 357
Tamás, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., & Cantrell, D. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052469 · Cited by 328
Research works printed but not linked: 63
- Warburg, 1956, On the origin of cancer cells, Science, 123, 309
- Garber, 2006, Energy deregulation: licensing tumors to grow, Science, 312, 1158
- Gambhir, 2002, Molecular imaging of cancer with positron emission tomography, Nat Rev Cancer, 2, 683
- Kahn, 2005, AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism, Cell Metab, 1, 15
- Hardie, 2006, AMP-activated protein kinase — development of the energy sensor concept, J Physiol, 574, 7
- Alessi, 2006, Lkb1-dependent signaling pathways, Annu Rev Biochem, 75, 137
- Hearle, 2006, Frequency and spectrum of cancers in the Peutz-Jeghers syndrome, Clin Cancer Res, 12, 3209
- Sanchez-Cespedes, 2002, Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung, Cancer Res, 62, 3659
- Carretero, 2004, Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene, Oncogene, 23, 4037
- Hawley, 2003, Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade, J Biol, 2, 28
- Sakamoto, 2005, Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction, EMBO J, 24, 1810
- Hurley, 2005, The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases, J Biol Chem, 280, 29060
- Woods, 2005, C(Ca2+)/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells, Cell Metab, 2, 21
- Stahmann, 2006, Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase β, Mol Cell Biol, 26, 5933
- Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471
- Bader, 2005, Oncogenic PI3K deregulates transcription and translation, Nat Rev Cancer, 5, 921
- Corradetti, 2004, Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome, Genes Dev, 18, 1533
- Shaw, 2004, The LKB1 tumor suppressor negatively regulates mTOR signaling, Cancer Cell, 6, 91
- Inoki, 2006, TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth, Cell, 126, 955
- Liu, 2006, Hypoxia-induced energy stress regulates mRNA translation and cell growth, Mol Cell, 21, 521
- Carretero J, Medina PP, Blanco R, Smit L, Tang M, Roncador G, Maestre L, Conde E, Lopez-Rios F, Clevers HC, et al.: Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene 2006, in press.
- Johannessen, 2005, The NF1 tumor suppressor critically regulates TSC2 and mTOR, Proc Natl Acad Sci USA, 102, 8573
- Imamura, 2001, Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line, Biochem Biophys Res Commun, 287, 562
- Jones, 2005, AMP-activated protein kinase induces a p53-dependent metabolic checkpoint, Mol Cell, 18, 283
- Igata, 2005, Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression, Circ Res, 97, 837
- Mandal, 2005, Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila, Dev Cell, 9, 843
- Bettencourt-Dias, 2004, Genome-wide survey of protein kinases required for cell cycle progression, Nature, 432, 980
- Moffat, 2006, A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen, Cell, 124, 1283
- Bardeesy, 2002, Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation, Nature, 419, 162
- Laderoute, 2006, 5′-AMP-activated protein kinase (AMPK) Is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments, Mol Cell Biol, 26, 5336
- Semenza, 1994, Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1, J Biol Chem, 269, 23757
- Iyer, 1998, Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha, Genes Dev, 12, 149
- Ryan, 1998, HIF-1 alpha is required for solid tumor formation and embryonic vascularization, EMBO J, 17, 3005
- Greijer, 2005, Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1), J Pathol, 206, 291
- Kim, 2004, Role of VHL gene mutation in human cancer, J Clin Oncol, 22, 4991
- Brugarolas, 2004, Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes, Cancer Cell, 6, 7
- Dekanty, 2005, The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-α/Sima, J Cell Sci, 118, 5431
- Brugarolas, 2003, TSC2 regulates VEGF through mTOR-dependent and -independent pathways, Cancer Cell, 4, 147
- Blancher, 2001, Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway, Cancer Res, 61, 7349
- Li, 2005, A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells, Cancer Res, 65, 3257
- Reiling, 2004, The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila, Genes Dev, 18, 2879
- Pozuelo Rubio, 2003, 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase, EMBO J, 22, 3514
- Majewski, 2004, Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak, Mol Cell, 16, 819
- Marsin, 2000, Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia, Curr Biol, 10, 1247
- Almeida, 2004, Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway, Nat Cell Biol, 6, 45
- Kim, 2006, HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia, Cell Metab, 3, 177
- Papandreou, 2006, HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption, Cell Metab, 3, 187
- Bui, 2006, Cancer's sweet tooth, Cancer Cell, 9, 419
- Ullah, 2006, The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism, J Biol Chem, 281, 9030
- Bensaad, 2006, TIGAR, a p53-inducible regulator of glycolysis and apoptosis, Cell, 126, 107
- Gottlieb, 2005, Mitochondrial tumour suppressors: a genetic and biochemical update, Nat Rev Cancer, 5, 857
- Pollard, 2005, Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations, Hum Mol Genet, 14, 2231
- Ramanathan, 2005, Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements, Proc Natl Acad Sci USA, 102, 5992
- Telang S, Yalcin A, Clem AL, Bucala R, Lane AN, Eaton JW, Chesney J: Ras transformation requires metabolic control by 6-phosphofructo-2-kinase. Oncogene 2006, in press.
- Hatzivassiliou, 2005, ATP citrate lyase inhibition can suppress tumor cell growth, Cancer Cell, 8, 311
- Ryan, 2000, Hypoxia-inducible factor-1α is a positive factor in solid tumor growth, Cancer Res, 60, 4010
- Rankin, 2005, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice, Mol Cell Biol, 25, 3163
- Bedogni, 2005, The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation, Cancer Cell, 8, 443
- Granville, 2006, Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway, Clin Cancer Res, 12, 679
- Serkova, 2005, Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications, Am J Pharmacogenomics, 5, 293
- Motoshima, 2006, AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer, J Physiol, 574, 63
- He, 2006, Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity, Cancer Res, 66, 1873
- Schneider, 2001, Prevention of pancreatic cancer induction in hamsters by metformin, Gastroenterology, 120, 1263
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Metadata
- Authors
- Shaw, R. J.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 18
- Issue
- 6
- Pages
- 598-608
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2045962235
- Cited by
- 550
- References
- 25
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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