Tumor cell metabolism: cancer's Achilles' heel
Open accessAbstract
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altered contribution of these organelles to metabolism are closely related. Similarly, the constitutive activation of signaling cascades that stimulate cell growth has a profound impact on anabolic metabolism. Here, we review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment. Specifically, we discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
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Cancer cells preferentially metabolize glucose by aerobic glycolysis, the Warburg effect.
“Cancer cells preferentially metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect.”
From An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway (2011) · cites this paper as [18]
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- Authors
- Kroemer, G., & Pouyssegur, J.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Kroemer, Guido
- ORCID
- Kroemer, Guido
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 13
- Issue
- 6
- Pages
- 472-482
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1991429659
- Cited by
- 2,337
- References
- 12
- Citations by year
- 2026: 68 · 2025: 101 · 2024: 130 · 2023: 124 · 2022: 155 · 2021: 110 · 2020: 136 · 2019: 125 · 2018: 128 · 2017: 131 · 2016: 136 · 2015: 150 · 2014: 171 · 2013: 150 · 2012: 137
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cancer metabolism, metabolic reprogramming, mitochondrial permeability transition, apoptosis resistance, signal transduction, anabolic metabolism, cancer therapy targets, cancer hallmarks
- MeSH terms
- Animals, Antineoplastic Agents, Energy Metabolism, Enzyme Inhibitors, Humans, Mitochondria, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Drug Design, Signal Transduction, Apoptosis, Tumor Escape, Cell Proliferation
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