Cited by 66Muscle Physiology and DisordersCongenital heart defects researchDevelopmental Biology and Gene Regulation

Muscle stem cells

Relaix, Frédéric, Marcelle, Christophe·2009·Current Opinion in Cell Biology

Abstract

Despite being mainly composed of highly differentiated contractile fibers, the adult skeletal muscle possesses the remarkable ability to regenerate, following injury. The cells that are responsible for this capacity are the satellite cells, a small population of adult stem cells positioned under the basal lamina of muscle fibers and that can give rise to both differentiated myogenic cells while maintaining a stem cell pool by a self-renewal mechanism. We will discuss here recent publications on the developmental origin of muscle stem cells, on the signaling pathways that affect their proliferation and differentiation, with reference to works on skeletal muscle formation in the embryo as well as the adult, using the mouse and chick as reference models.

Integrity signals

Registry

Crossref · 10.1016/j.ceb.2009.10.002

Cites

51 of 51 references verified0 citation errors · 0 not checkable

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  • Satellite cells are primarily responsible for driving skeletal muscle repair in response to damaging stimuli such as exercise contraction.

    “Muscle stem cells commonly known as satellite cells, are primarily responsible for driving the skeletal muscle repair process to potentially damaging stimuli, such as mechanical stress elicited by exercise contraction.”
  • Satellite cells are primarily involved in muscle regeneration in response to injury such as resistance exercise.

    “Satellite cells are primarily involved in muscle regeneration in response to injury, such as those sustained following resistance exercise [18].”

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Authors
Relaix, F., & Marcelle, C.
Affiliations
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Marcelle, Christophe
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2009-12
Volume
21
Issue
6
Pages
748-753
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2026777415
Cited by
66
References
51
Citations by year
2024: 1 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 8
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
muscle stem cells, satellite cells, skeletal muscle regeneration, myogenesis, self-renewal, signaling pathways, mice, chick embryo
MeSH terms
Animals, Cell Differentiation, Chick Embryo, Embryo, Mammalian, Humans, Stem Cells, Muscle, Skeletal, Gene Expression Regulation, Developmental, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice, Adult Stem Cells, Precursor Cells, B-Lymphoid

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