Muscle stem cells
Abstract
Despite being mainly composed of highly differentiated contractile fibers, the adult skeletal muscle possesses the remarkable ability to regenerate, following injury. The cells that are responsible for this capacity are the satellite cells, a small population of adult stem cells positioned under the basal lamina of muscle fibers and that can give rise to both differentiated myogenic cells while maintaining a stem cell pool by a self-renewal mechanism. We will discuss here recent publications on the developmental origin of muscle stem cells, on the signaling pathways that affect their proliferation and differentiation, with reference to works on skeletal muscle formation in the embryo as well as the adult, using the mouse and chick as reference models.
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Satellite cells are primarily responsible for driving skeletal muscle repair in response to damaging stimuli such as exercise contraction.
“Muscle stem cells commonly known as satellite cells, are primarily responsible for driving the skeletal muscle repair process to potentially damaging stimuli, such as mechanical stress elicited by exercise contraction.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [18]
Satellite cells are primarily involved in muscle regeneration in response to injury such as resistance exercise.
“Satellite cells are primarily involved in muscle regeneration in response to injury, such as those sustained following resistance exercise [18].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [18]
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Skeletal Muscle Development: From Stem Cells to Body Movement
Deries, M., Gonçalves, A. B., & Þorsteinsdóttir, S. (2020) · Learning materials in biosciences · doi:10.1007/978-3-030-43939-2_9 · Cited by 3 · see citing works
Hippo pathway inhibition promotes metabolic adaptability and antioxidant response in myoblasts
Liu, Q., Pan, S., Li, P., & Dixon, R. A. F. (2023) · Scientific Reports · doi:10.1038/s41598-023-29372-8 · Cited by 3 · see citing works
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Skeletal Muscle Stem Cell Niche from Birth to Old Age
Barbu, M. G., Boboc, A. E., Filip, L., Bugnar, O. L., Crețoiu, D., Suciu, N., Toader, O. D., Creţoiu, S. M., & Voinea, S.-C. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93502 · Cited by 1 · see citing works
Myogenic Differentiation of ES Cells for Therapies in Neuromuscular Diseases: Progress to Date
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Characterization and Function of the ~70kDa Immunoreactive Species of Pannexin3 in Rhabdomyosarcomas
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Stem cell activation in skeletal muscle regeneration
FuHuating, X., & Hu, W. (2015)
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Identification and characterisation of new genes associated to multiminicore disease
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- Authors
- Relaix, F., & Marcelle, C.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Marcelle, Christophe
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 21
- Issue
- 6
- Pages
- 748-753
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2026777415
- Cited by
- 66
- References
- 51
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- muscle stem cells, satellite cells, skeletal muscle regeneration, myogenesis, self-renewal, signaling pathways, mice, chick embryo
- MeSH terms
- Animals, Cell Differentiation, Chick Embryo, Embryo, Mammalian, Humans, Stem Cells, Muscle, Skeletal, Gene Expression Regulation, Developmental, Satellite Cells, Skeletal Muscle, Cell Proliferation, Mice, Adult Stem Cells, Precursor Cells, B-Lymphoid
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