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The mitochondrial unfolded protein response–synchronizing genomes
Open accessAbstract
Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologically, dysfunction of the proteome is sensed and communicated to the nucleus, where an extensive transcriptional program, aimed to repair the damage, is activated. This feedback loop, termed the mitochondrial unfolded protein response (UPR(mt)), synchronizes the activity of the mitochondrial and nuclear genomes and as such ensures the quality of the mitochondrial proteome. Here we review the recent advances in the UPR(mt) field and discuss its induction, signaling, communication with the other mitochondrial and major cellular regulatory pathways, as well as its potential implications on health and lifespan.
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“On the other hand, multiple cellular stresses associated with the aging process trigger the mitochondrial unfolded protein response (UPRmt) that serves as a critical mechanism for promoting cellular recovery and mitochondrial network survival (68).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [68]
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Metadata
- Authors
- Jovaisaite, V., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Auwerx, Johan
- ORCID
- Auwerx, Johan
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 33
- Pages
- 74-81
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC4380587
- OpenAlex
- W2064966129
- Cited by
- 131
- References
- 60
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 16 · 2016: 12 · 2015: 13
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- NIH (R01AG043930)
- SNSF (31003A-140780)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial unfolded protein response, mitochondrial proteome, mitochondrial stress, mitochondrial chaperone, mitochondrial protease, mitochondrial-nuclear communication, transcriptional regulation, lifespan, mitochondrial dysfunction
- MeSH terms
- Aging, Animals, Cell Nucleus, Humans, Mammals, Mitochondria, Signal Transduction, Genome, Cytoprotection, Proteome, Mitochondrial Proteins, Genome, Mitochondrial, Unfolded Protein Response
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