Cited by 131Mitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and Therapy

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The mitochondrial unfolded protein response–synchronizing genomes

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Jovaisaite, Virginija, Auwerx, Johan·2015·Current Opinion in Cell Biology

DOI 10.1016/j.ceb.2014.12.003PMC PMC4380587

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Abstract

Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologically, dysfunction of the proteome is sensed and communicated to the nucleus, where an extensive transcriptional program, aimed to repair the damage, is activated. This feedback loop, termed the mitochondrial unfolded protein response (UPR(mt)), synchronizes the activity of the mitochondrial and nuclear genomes and as such ensures the quality of the mitochondrial proteome. Here we review the recent advances in the UPR(mt) field and discuss its induction, signaling, communication with the other mitochondrial and major cellular regulatory pathways, as well as its potential implications on health and lifespan.

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Authors: Jovaisaite, V., & Auwerx, J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Auwerx, Johan
ORCID: Auwerx, Johan
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2015-04
Volume: 33
Pages: 74-81
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/j.ceb.2014.12.003
PMC: PMC4380587
OpenAlex: W2064966129
Cited by: 131
References: 60
Citations by year: 2026: 4 · 2025: 6 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 16 · 2016: 12 · 2015: 13
FWCI: 1.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: NIH (R01AG043930)
SNSF (31003A-140780)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial unfolded protein response, mitochondrial proteome, mitochondrial stress, mitochondrial chaperone, mitochondrial protease, mitochondrial-nuclear communication, transcriptional regulation, lifespan, mitochondrial dysfunction
MeSH terms: Aging, Animals, Cell Nucleus, Humans, Mammals, Mitochondria, Signal Transduction, Genome, Cytoprotection, Proteome, Mitochondrial Proteins, Genome, Mitochondrial, Unfolded Protein Response

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The mitochondrial unfolded protein response–synchronizing genomes

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