Cited by 340Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

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Polysaccharide Processing and Presentation by the MHCII Pathway

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Cobb, Brian A, Wang, Qun, Tzianabos, Arthur O, Kasper, Dennis L·2004·Cell

DOI 10.1016/j.cell.2004.05.001PMC PMC2917993

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Abstract

The adaptive immune system functions through the combined action of antigen-presenting cells (APCs) and T cells. Specifically, class I major histocompatibility complex antigen presentation to CD8(+) T cells is limited to proteosome-generated peptides from intracellular pathogens while the class II (MHCII) endocytic pathway presents only proteolytic peptides from extracellular pathogens to CD4(+) T cells. Carbohydrates have been thought to stimulate immune responses independently of T cells; however, zwitterionic polysaccharides (ZPSs) from the capsules of some bacteria can activate CD4(+) T cells. Here we show that ZPSs are processed to low molecular weight carbohydrates by a nitric oxide-mediated mechanism and presented to T cells through the MHCII endocytic pathway. Furthermore, these carbohydrates bind to MHCII inside APCs for presentation to T cells. Our observations begin to elucidate the mechanisms by which some carbohydrates induce important immunologic responses through T cell activation, suggesting a fundamental shift in the MHCII presentation paradigm.

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Authors: Cobb, B. A., Wang, Q., Tzianabos, A. O., & Kasper, D. L.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Kasper, Dennis L
ORCID: Cobb, Brian A
Wang, Qun
Kasper, Dennis L
Venue: Cell
Publisher: Elsevier BV
Published: 2004-05
Volume: 117
Issue: 5
Pages: 677-687
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2004.05.001
PMC: PMC2917993
OpenAlex: W1988183869
Cited by: 340
References: 48
Citations by year: 2026: 9 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 23 · 2020: 19 · 2019: 15 · 2018: 10 · 2017: 12 · 2016: 19 · 2015: 13 · 2014: 18 · 2013: 19 · 2012: 20
FWCI: 5.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3364 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI007061, AI52397, AI039576, R01AI039576, R01AI052397, T32AI007061)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: zwitterionic polysaccharides, MHC class II antigen presentation, nitric oxide, T cell activation, antigen-presenting cells, bacterial capsule, CD4+ T cells, endocytic pathway
MeSH terms: Animals, Antigen-Presenting Cells, Histocompatibility Antigens Class II, Endocytosis, Polysaccharides, Receptors, Antigen, T-Cell, T-Lymphocytes, Antigen Presentation, Mice

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Polysaccharide Processing and Presentation by the MHCII Pathway

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