Cited by 340Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Polysaccharide Processing and Presentation by the MHCII Pathway

Open access

Cobb, Brian A, Wang, Qun, Tzianabos, Arthur O, Kasper, Dennis L·2004·Cell

DOI 10.1016/j.cell.2004.05.001PMC PMC2917993

Open this paper in CoChat — free account Open PDF

Abstract

The adaptive immune system functions through the combined action of antigen-presenting cells (APCs) and T cells. Specifically, class I major histocompatibility complex antigen presentation to CD8(+) T cells is limited to proteosome-generated peptides from intracellular pathogens while the class II (MHCII) endocytic pathway presents only proteolytic peptides from extracellular pathogens to CD4(+) T cells. Carbohydrates have been thought to stimulate immune responses independently of T cells; however, zwitterionic polysaccharides (ZPSs) from the capsules of some bacteria can activate CD4(+) T cells. Here we show that ZPSs are processed to low molecular weight carbohydrates by a nitric oxide-mediated mechanism and presented to T cells through the MHCII endocytic pathway. Furthermore, these carbohydrates bind to MHCII inside APCs for presentation to T cells. Our observations begin to elucidate the mechanisms by which some carbohydrates induce important immunologic responses through T cell activation, suggesting a fundamental shift in the MHCII presentation paradigm.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2004.05.001

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cellular and Molecular Immunology
Abbas, A. K., Lichtman, A. H., & Pillai, S. S. (1994) · Cited by 3,571
Cellular and Molecular Immunology
Denman, A. M. (1992) · Postgraduate Medical Journal · doi:10.1136/pgmj.68.798.305 · Cited by 2,807
Structures and mechanisms of glycosyl hydrolases
Davies, G. J., & Henrissat, B. (1995) · Structure · doi:10.1016/s0969-2126(01)00220-9 · Cited by 2,118
Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production
Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics · doi:10.1038/ng0295-202 · Cited by 921
CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES
Watts, C. K. W. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.821 · Cited by 754
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
Laubach, V. E., Shesely, E. G., Smithies, O., & Sherman, P. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10688 · Cited by 580
Mediation by HLA-DM of dissociation of peptides from HLA-DR
Sloan, V. S., Cameron, P. M., Porter, G., Gammon, M. T., Amaya, M., Mellins, E., & Zaller, D. M. (1995) · Nature · doi:10.1038/375802a0 · Cited by 546
Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development
Shi, G., Villadangos, J. A., Dranoff, G., Small, C. G., Gu, L., Haley, K. J., Riese, R. J., Ploegh, H. L., & Chapman, H. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80020-5 · Cited by 524
Redox signaling in macrophages
Forman, H. J. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00010-3 · Cited by 521
Glycosidase mechanisms
Rye, C. S., & Withers, S. G. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00135-6 · Cited by 470

Show all 48 references

Sorted by citations

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
“…PSA also activates toll-like receptor (TLR) 2 expressed on the surface of DCs, which triggers the release of cytokines that promote IL-10 production by T cells (Cobb et al., 2004; Dasgupta et al., 2014; Johnson et al., 2015; Mazmanian et al., 2005, 2008; Telesford et al., 2015; Wang et al., 2006).”
Background
The effects of β-glucan on human immune and cancer cells
Chan, G., Chan, W. K., & Sze, D. (2009) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-2-25 · Cited by 896
Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
Cerutti, A., Cols, M., & Puga, I. (2013) · Nature reviews. Immunology · doi:10.1038/nri3383 · Cited by 837
Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions
Weidenmaier, C., & Peschel, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1861 · Cited by 799
Carbohydrate vaccines: developing sweet solutions to sticky situations?
Astronomo, R. D., & Burton, D. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3012 · Cited by 629
The alpha-gal story: Lessons learned from connecting the dots
Steinke, J. W., Platts‐Mills, T. A. E., & Commins, S. P. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1947 · Cited by 379
A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design
Avci, F. Y., Li, X., Tsuji, M., & Kasper, D. L. (2011) · Nature Medicine · doi:10.1038/nm.2535 · Cited by 365
The love–hate relationship between bacterial polysaccharides and the host immune system
Mazmanian, S. K., & Kasper, D. L. (2006) · Nature reviews. Immunology · doi:10.1038/nri1956 · Cited by 362
Probiotics: Properties, Examples, and Specific ApplicationsPreprint
Behnsen, J., Deriu, E., Sassone‐Corsi, M., & Raffatellu, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a010074 · Cited by 305
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
Dasgupta, S., Erturk-Hasdemir, D., Ochoa-Reparaz, J., Reinecker, H.-C., & Kasper, D. L. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.006 · Cited by 292
Self-citation
Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity
Vinderola, G., Perdigón, G., Duarte, J., Farnworth, E. R., & Matar, C. (2006) · Cytokine · doi:10.1016/j.cyto.2007.01.003 · Cited by 291
Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules
Cress, B. F., Englaender, J. A., He, W., Kasper, D., Linhardt, R. J., & Koffas, M. A. G. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12056 · Cited by 282
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
Wang, Q., McLoughlin, R. M., Cobb, B. A., Charrel-Dennis, M., Zaleski, K. J., Golenbock, D. T., Tzianabos, A. O., & Kasper, D. L. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20062008 · Cited by 275
Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
Pifferi, C., Fuentes, R., & Fernández‐Tejada, A. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-020-00244-3 · Cited by 272
Coordination of tolerogenic immune responses by the commensal microbiota
Round, J. L., O’Connell, R. M., & Mazmanian, S. K. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.007 · Cited by 269
Regulation of Homeostasis and Inflammation in the Intestine
MacDonald, T. T., Monteleone, I., Fantini, M. C., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.047 · Cited by 267
Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
Kudelka, M. R., Ju, T., Heimburg‐Molinaro, J., & Cummings, R. D. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2014.11.002 · Cited by 268
Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments
Shivatare, S. S., Shivatare, V. S., & Wong, C. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01032 · Cited by 266
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules
Watts, C. K. W. (2004) · Nature Immunology · doi:10.1038/ni1088 · Cited by 257
Oxidative depolymerization of polysaccharides by reactive oxygen/nitrogen species
Duan, J., & Kasper, D. L. (2011) · Glycobiology · doi:10.1093/glycob/cwq171 · Cited by 267
A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39 + Foxp3 + T cells and T reg function
Telesford, K. M., Yan, W., Ochoa-Reparaz, J., Pant, A., Kircher, C., Christy, M. A., Begum-Haque, S., Kasper, D. L., & Kasper, L. H. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1056973 · Cited by 252
Self-citation
Polysaccharides as vaccine adjuvants
Sun, B., Yu, S., Zhao, D., Guo, S., Wang, X., & Zhao, K. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.07.040 · Cited by 243
Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus
Fontaine, T., Delangle, A., Simenel, C., Coddeville, B., van Vliet, S. J., van Kooyk, Y., Bozza, S., Moretti, S., Schwarz, F., Trichot, C., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002372 · Cited by 241
Human gut microbiota and bifidobacteria: from composition to functionality
Turroni, F., Ribbera, A., Foroni, E., van Sinderen, D., & Ventura, M. (2008) · Antonie van Leeuwenhoek · doi:10.1007/s10482-008-9232-4 · Cited by 247
How Bacterial Carbohydrates Influence the Adaptive Immune System
Avci, F. Y., & Kasper, D. L. (2009) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101159 · Cited by 242
Cancer vaccines and carbohydrate epitopes
Heimburg‐Molinaro, J., Lum, M. A., Vijay, G. V., Jain, M., Almogren, A., & Rittenhouse‐Olson, K. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.09.009 · Cited by 227
Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells
Duan, J., Chung, H., Troy, E. B., & Kasper, D. L. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.01.005 · Cited by 231
Bacterial Glycans: Key Mediators of Diverse Host Immune Responses
Comstock, L. E., & Kasper, D. L. (2006) · Cell · doi:10.1016/j.cell.2006.08.021 · Cited by 215
Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach
Seeberger, P. H. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01210 · Cited by 215
Combined schedules of pneumococcal conjugate and polysaccharide vaccines: is hyporesponsiveness an issue?
O’Brien, K. L., Hochman, M. E., & Goldblatt, D. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70210-4 · Cited by 213
Vaccines based on the cell surface carbohydrates of pathogenic bacteria
Jones, C. (2005) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652005000200009 · Cited by 184
Dendritic cells and C‐type lectin receptors: coupling innate to adaptive immune responses
van Vliet, S. J., García-Vallejo, J. J., & van Kooyk, Y. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.55 · Cited by 188
Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide
Malley, R., Srivastava, A. K., Lipsitch, M., Thompson, C. M., Watkins, A. C., Tzianabos, A. O., & Anderson, P. W. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2187-2195.2006 · Cited by 177
Innate signaling and regulation of Dendritic cell immunity
van Vliet, S. J., den Dunnen, J., Gringhuis, S. I., Geijtenbeek, T. B. H., & van Kooyk, Y. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.05.006 · Cited by 177
Immune responses to commensal and environmental microbes
Pamer, E. G. (2007) · Nature Immunology · doi:10.1038/ni1526 · Cited by 173
Marginal zone B cells in lymphocyte activation and regulation
Carvalho, T. L., Foote, J. B., & Kearney, J. F. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.04.009 · Cited by 159
Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation
Morelli, L., Poletti, L., & Lay, L. (2011) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201100296 · Cited by 155
The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA
Surana, N. K., & Kasper, D. L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01075.x · Cited by 160
The molecular basis for the immunogenicity ofCryptococcus neoformansmannoproteins
Levitz, S. M., & Specht, C. A. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00071.x · Cited by 159
Benefits of bacteria-derived exopolysaccharides on gastrointestinal microbiota, immunity and health
Oerlemans, M. M. P., Akkerman, R., Ferrari, M. D. L., Walvoort, M. T. C., & de Vos, P. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104289 · Cited by 159
Polysaccharides in Lentinus edodes : Isolation, Structure, Immunomodulating Activity and Future Prospective
Xu, X., Yan, H., Tang, J., Chen, J., & Zhang, X. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.587616 · Cited by 152
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host
Torrelles, J. B., & Schlesinger, L. S. (2010) · Tuberculosis · doi:10.1016/j.tube.2010.02.003 · Cited by 146
Good Gone Bad: One Toxin Away From Disease for Bacteroides fragilis
Valguarnera, E., & Wardenburg, J. B. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.003 · Cited by 141
A novel strain of Bacteroides fragilis enhances phagocytosis and polarises M1 macrophages
Deng, H., Li, Z., Tan, Y., Guo, Z., Liu, Y., Wang, Y., Yuan, Y., Yang, R., Bi, Y., Bai, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep29401 · Cited by 143
Symbionts exploit complex signaling to educate the immune system
Erturk-Hasdemir, D., Oh, S. F., Okan, N. A., Stefanetti, G., Gazzaniga, F. S., Seeberger, P. H., Plevy, S. E., & Kasper, D. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915978116 · Cited by 129
Self-citation
Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives
Berti, F., & Adamo, R. (2013) · ACS Chemical Biology · doi:10.1021/cb400423g · Cited by 126
Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates
Silva, R. A. D., Wang, Q., Chidley, T., Appulage, D. K., & Andreana, P. R. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902607a · Cited by 127
From Cancer Therapy to Winemaking: The Molecular Structure and Applications of β-Glucans and β-1, 3-Glucanases
Caseiro, C., Dias, J., Fontes, C. M. G. A., & Bule, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063156 · Cited by 129
Microbial Metabolites, Postbiotics, and Intestinal Epithelial Function
Mayorgas, A., Dotti, I., & Salas, A. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000188 · Cited by 130
The importance of the glycosylation of antimicrobial peptides: natural and synthetic approaches
Bednarska, N. G., Wren, B. W., & Willcocks, S. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.02.001 · Cited by 112
Emergence and significance of carbohydrate-specific antibodies
Kappler, K., & Hennet, T. (2020) · Genes & Immunity · doi:10.1038/s41435-020-0105-9 · Cited by 118
Polysaccharide structure dictates mechanism of adaptive immune response to glycoconjugate vaccines
Sun, X., Stefanetti, G., Berti, F., & Kasper, D. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816401115 · Cited by 112
The Fidelity, Occasional Promiscuity, and Versatility of T Cell Receptor Recognition
Godfrey, D. I., Rossjohn, J., & McCluskey, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.004 · Cited by 111
Specificity in cancer immunotherapy
Schietinger, A., Philip, M., & Schreiber, H. W. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.07.001 · Cited by 109
Peripheral education of the immune system by the colonic microbiota
Kuhn, K. A., & Stappenbeck, T. S. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.002 · Cited by 108
Carbohydrates and T cells: A sweet twosome
Avci, F. Y., Li, X., Tsuji, M., & Kasper, D. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.05.005 · Cited by 106
IFN-γ Regulated Chemokine Production Determines the Outcome of Staphylococcus aureus Infection
McLoughlin, R. M., Lee, J. C., Kasper, D. L., & Tzianabos, A. O. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1323 · Cited by 101
The direct and indirect effects of glycans on immune function
Baum, L. G., & Cobb, B. A. (2017) · Glycobiology · doi:10.1093/glycob/cwx036 · Cited by 100
Mechanisms of the hygiene hypothesis — molecular and otherwise
Vercelli, D. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.09.002 · Cited by 101
Wall teichoic acids are dispensable for anchoring the PNAG exopolysaccharide to the Staphylococcus aureus cell surface
Vergara-Irigaray, M., Maira‐Litrán, T., Merino, N., Pier, G. B., Penadés, J. R., & Lasa, Í. (2008) · Microbiology · doi:10.1099/mic.0.2007/013292-0 · Cited by 101
Immune responses to polysaccharides: Lessons from humans and mice
González‐Fernández, Á., Faro, J., & Fernández, C. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.11.042 · Cited by 98
Coming of age: carbohydrates and immunity
Cobb, B. A., & Kasper, D. L. (2005) · European Journal of Immunology · doi:10.1002/eji.200425889 · Cited by 97
The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites
Schneider, C., Smith, D. F., Cummings, R. D., Boligan, K. F., Hamilton, R. G., Bochner, B. S., Miescher, S., Simon, H., Pashov, A. D., Vassilev, T. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010524 · Cited by 97
Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens
Cobb, B. A., & Kasper, D. L. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00591.x · Cited by 96
Microbial diversity in the human intestine and novel insights from metagenomics
Ventura, M. (2009) · Frontiers in bioscience · doi:10.2741/3445 · Cited by 92
Antibodies to citrullinated proteins: molecular interactions and arthritogenicity
Uysal, H., Nandakumar, K. S., Kessel, C., Haag, S., Carlsén, S., Burkhardt, H., & Holmdahl, R. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00853.x · Cited by 91
Infection, inflammation and host carbohydrates: A Glyco-Evasion Hypothesis
Kreisman, L. S. C., & Cobb, B. A. (2012) · Glycobiology · doi:10.1093/glycob/cws070 · Cited by 90
Reconsideration of the Use of Meningococcal Polysaccharide Vaccine
Granoff, D. M., & Pollard, A. J. (2007) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3180cc2c25 · Cited by 89
Development in the Concept of Bacterial Polysaccharide Repeating Unit-Based Antibacterial Conjugate Vaccines
Rohokale, R., & Guo, Z. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00559 · Cited by 88
Roles for major histocompatibility complex glycosylation in immune function
Ryan, S. O., & Cobb, B. A. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0309-9 · Cited by 93
Carbohydrates as T-cell antigens with implications in health and disease
Sun, L., Middleton, D. R., Wantuch, P. L., Ozdilek, A., & Avci, F. Y. (2016) · Glycobiology · doi:10.1093/glycob/cww062 · Cited by 89
Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity
Malley, R., & Anderson, P. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121383109 · Cited by 86
Carbohydrate based vaccines
Vliegenthart, J. F. G. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.053 · Cited by 85
Antigen presentation and recognition in bacterial infections
Kaufmann, S. H. E., & Schaible, U. E. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.12.004 · Cited by 80
Characterization of Specific Immune Responses to Different Aspergillus Antigens during the Course of Invasive Aspergillosis in Hematologic Patients
Potenza, L., Vallerini, D., Barozzi, P., Riva, G., Forghieri, F., Beauvais, A., Beau, R., Candoni, A., Maertens, J., Rossi, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074326 · Cited by 81
Microbial carbohydrate depolymerization by antigen-presenting cells: Deamination prior to presentation by the MHCII pathway
Duan, J., Avci, F. Y., & Kasper, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800974105 · Cited by 81
Strengths and weaknesses of pneumococcal conjugate vaccines
Micoli, F., Romano, M. R., Carboni, F., Adamo, R., & Berti, F. (2023) · Glycoconjugate Journal · doi:10.1007/s10719-023-10100-3 · Cited by 83
Plant glycans: friend or foe in vaccine development?
Bosch, D., & Schots, A. (2010) · Expert Review of Vaccines · doi:10.1586/erv.10.83 · Cited by 76
Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation
Johnson, J. L., Jones, M. B., & Cobb, B. A. (2014) · Glycobiology · doi:10.1093/glycob/cwu117 · Cited by 77
Polysaccharide A from the capsule of Bacteroides fragilis induces clonal CD4+ T cell expansion
Johnson, J. L., Jones, M. B., & Cobb, B. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.621771 · Cited by 74
Recent advances on smart glycoconjugate vaccines in infections and cancer
Anderluh, M., Berti, F., Bzducha‐Wróbel, A., Chiodo, F., Colombo, C., Compostella, F., Durlik-Popińska, K., Ferhati, X., Holmdahl, R., Jovanović, D. J., et al. (2021) · FEBS Journal · doi:10.1111/febs.15909 · Cited by 75
Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
Zhang, Q., Gimeno, A., Santana-Mederos, D., Wang, Z., Valdés-Balbín, Y., Rodríguez-Noda, L., Hansen, T., Kong, L., Shen, M., Overkleeft, H. S., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b00454 · Cited by 73
Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities
Ouerfelli, O., Warren, J. D., Wilson, R. M., & Danishefsky, S. J. (2005) · Expert Review of Vaccines · doi:10.1586/14760584.4.5.677 · Cited by 71
Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses
Nishat, S., & Andreana, P. R. (2016) · Vaccines · doi:10.3390/vaccines4020019 · Cited by 72
Glycolipid antigens and autoantibodies in autoimmune neuropathies
Willison, H. J., & Goodyear, C. S. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.05.001 · Cited by 70
Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR
Cobb, B. A., & Kasper, D. L. (2008) · Glycobiology · doi:10.1093/glycob/cwn050 · Cited by 70
The Starting Lineup: Key Microbial Players in Intestinal Immunity and Homeostasis
Reading, N. C., & Kasper, D. L. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00148 · Cited by 72
Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II‐dependent pathway for antigen presentation
Vélez, C. D., Lewis, C. J., Kasper, D. L., & Cobb, B. A. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02924.x · Cited by 69
Protection against Pneumococcal Colonization and Fatal Pneumonia by a Trivalent Conjugate of a Fusion Protein with the Cell Wall Polysaccharide
Lu, Y., Forte, S., Thompson, C. M., Anderson, P. W., & Malley, R. (2009) · Infection and Immunity · doi:10.1128/iai.01554-08 · Cited by 66
DNA Vaccine Expressing the Mimotope of GD2 Ganglioside Induces Protective GD2 Cross-reactive Antibody Responses
Bolesta, E., Kowalczyk, A., Wierzbicki, A. J., Rotkiewicz, P., Bambach, B. J., Tsao, C.-Y., Horwacik, I., Koliński, A., Rokita, H., Brecher, M. L., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2164 · Cited by 65
Total Synthesis of the Bacteroides fragilis Zwitterionic Polysaccharide A1 Repeating Unit
Pragani, R., & Seeberger, P. H. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1087375 · Cited by 65
Finding a needle in a haystack: Bacteroides fragilis polysaccharide A as the archetypical symbiosis factor
Ertürk-Hasdemir, D., & Kasper, D. L. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13660 · Cited by 69
An Overview of Structural Features of Antibacterial Glycoconjugate Vaccines That Influence Their Immunogenicity
Khatun, F., Stephenson, R. J., & Tóth, I. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201603599 · Cited by 61
Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation
Johnson, J. L., Jones, M. B., & Cobb, B. A. (2017) · Glycobiology · doi:10.1093/glycob/cwx093 · Cited by 61
Bacteroides fragilis–Stimulated Interleukin-10 Contains Expanding Disease
Cohen‐Poradosu, R., McLoughlin, R. M., Lee, J. C., & Kasper, D. L. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir277 · Cited by 60
Synthesis of a Single-Molecule l -Rhamnose-Containing Three-Component Vaccine and Evaluation of Antigenicity in the Presence of Anti- l -Rhamnose Antibodies
Sarkar, S., Lombardo, S. A., Herner, D. N., Talan, R. S., Wall, K. A., & Sucheck, S. J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja107029z · Cited by 58
Ascorbic acid induced degradation of polysaccharide from natural products: a review
Zou, M., Nie, S., Yin, J., & Xie, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.193 · Cited by 57
Carbohydrate-Based Vaccines: An Overview
Hütter, J., & Lepenies, B. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2874-3_1 · Cited by 55

Authors: Cobb, B. A., Wang, Q., Tzianabos, A. O., & Kasper, D. L.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Kasper, Dennis L
ORCID: Cobb, Brian A
Wang, Qun
Kasper, Dennis L
Venue: Cell
Publisher: Elsevier BV
Published: 2004-05
Volume: 117
Issue: 5
Pages: 677-687
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2004.05.001
PMC: PMC2917993
OpenAlex: W1988183869
Cited by: 340
References: 48
Citations by year: 2026: 9 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 23 · 2020: 19 · 2019: 15 · 2018: 10 · 2017: 12 · 2016: 19 · 2015: 13 · 2014: 18 · 2013: 19 · 2012: 20
FWCI: 5.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3364 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI007061, AI52397, AI039576, R01AI039576, R01AI052397, T32AI007061)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: zwitterionic polysaccharides, MHC class II antigen presentation, nitric oxide, T cell activation, antigen-presenting cells, bacterial capsule, CD4+ T cells, endocytic pathway
MeSH terms: Animals, Antigen-Presenting Cells, Histocompatibility Antigens Class II, Endocytosis, Polysaccharides, Receptors, Antigen, T-Cell, T-Lymphocytes, Antigen Presentation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polysaccharide Processing and Presentation by the MHCII Pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks