The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution
Open accessAbstract
MicroRNAs are small noncoding RNAs that serve as posttranscriptional regulators of gene expression in higher eukaryotes. Their widespread and important role in animals is highlighted by recent estimates that 20%-30% of all genes are microRNA targets. Here, we report that a large set of genes involved in basic cellular processes avoid microRNA regulation due to short 3'UTRs that are specifically depleted of microRNA binding sites. For individual microRNAs, we find that coexpressed genes avoid microRNA sites, whereas target genes and microRNAs are preferentially expressed in neighboring tissues. This mutually exclusive expression argues that microRNAs confer accuracy to developmental gene-expression programs, thus ensuring tissue identity and supporting cell-lineage decisions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The miRNAs in the first class are in line with studies showing that the expression level of the predicted targets is generally higher before differentiation, and that some miRNAs dampen the output of the transcriptionally down-regulated mRNAs to facilitate a faster transition in gene expression (Stark et al., 2005).”
From Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes (2008) · cites this paper as Stark et al., 2005
In the citing paper
“As the silencing of loci is generally efficient, one might conclude that for most of the time in most mature neurons, some miRNAs are doing very little indeed, consistent with the idea that miRNAs confer robustness to programs of gene expression [11,12].”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [12]
In the citing paper
“mRNAs from genes required for general cellular machinery are protected from miRNA action through possession of short 3' UTRs that are poor miRNA targets and genes required for specific cellular functions of the specific cell type are often miRNA anti-targets - that is, their 3' UTRs lack sequences that would enable binding of co-expressed miRNAs [12].”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [12]
In the citing paper
“For instance, in zebrafish, miR-430 targets a large number of maternally deposited transcripts at the onset of zygotic transcription [6] and many examples of spatially exclusive expression domains of miRNAs and their targets have been documented (for example, [12,53]).”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [12]
In the citing paper
“A common feature of miRNA function is one of mutually exclusive expression of miRNAs and their target mRNAs [11,12].”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [12]
In the citing paper
“This profile is one of the best conserved miRNA patterns, as a similar restriction to mature neurons is seen for mouse and fly miR-124 [12,30].”
From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [12]
In the citing paper
“A change in the expression levels of miRNAs can tip the balance and result in repression or activation of many functionally important target genes101,102.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [101]
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 1,000
Lee, B., Bhinge, A., & Iyer, V. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1313 · Cited by 157
Context-dependent functions of specific microRNAs in neuronal development
Gao, F. (2010) · Neural Development · doi:10.1186/1749-8104-5-25 · Cited by 150
p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G. H., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.65 · Cited by 153
MicroRNAs in brain development and physiology
Coolen, M., & Bally‐Cuif, L. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.006 · Cited by 157
Mechanistic Insights into MicroRNA-Mediated Gene SilencingPreprint
Duchaîne, T. F., & Fabian, M. R. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032771 · Cited by 156
Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein
Parker, J. S., Parizotto, E. A., Wang, M., Roe, S. M., & Barford, D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.012 · Cited by 157
MicroRNA-directed regulation: to cleave or not to cleave
Mallory, A. C., & Bouché, N. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2008.03.007 · Cited by 146
Experimental validation of the importance of seed complement frequency to siRNA specificity
Anderson, E. M., Birmingham, A., Baskerville, S., Reynolds, A., Maksimova, E. M., Leake, D., Federov, Y., Karpilow, J. M., & Khvorova, A. (2008) · RNA · doi:10.1261/rna.704708 · Cited by 149
microRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene
Gillen, A. E., Gosalia, N., Leir, S., & Harris, A. (2011) · Biochemical Journal · doi:10.1042/bj20110672 · Cited by 146
Granjon, A., Gustin, M., Rieusset, J., Lefai, É., Meugnier, E., Güller, I., Cerutti, C., Paultre, C. Z., Disse, E., RABASA-LHORET, R. P. R., et al. (2009) · Diabetes · doi:10.2337/db09-0165 · Cited by 141
Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease
Georges, M., Coppieters, W. R., & Charlier, C. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.04.005 · Cited by 140
Genome-Wide Analysis of mRNAs Regulated by Drosha and Argonaute Proteins in Drosophila melanogaster
Rehwinkel, J., Natalin, P., Stark, A., Brennecke, J., Cohen, S. M., & Izaurralde, E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2965-2975.2006 · Cited by 145
Self-citationMicroRNA Control of TGF-β Signaling
Suzuki, H. I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071901 · Cited by 141
MicroRNAs – targeting and target prediction
Saito, T., & Sætrom, P. (2010) · New Biotechnology · doi:10.1016/j.nbt.2010.02.016 · Cited by 138
Chhabra, R., Adlakha, Y. K., Hariharan, M., Scaria, V., & Saini, N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005848 · Cited by 136
Characterisation of microRNA expression in post-natal mouse mammary gland development
Avril-Sassen, S., Goldstein, L. D., Stingl, J., Blenkiron, C., Quesne, J. P. C. L., Spiteri, I., Karagavriilidou, K., Watson, C. J., Tavaré, S., Miska, E. A., et al. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-548 · Cited by 136
Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates
Hiard, S., Charlier, C., Coppieters, W. R., Georges, M., & Baurain, D. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp926 · Cited by 133
Tubulin polymerization‐promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
Lehotzky, A., Lau, P., Tőkési, N., Muja, N., Hudson, L. D., & Ovádi, J. (2009) · Glia · doi:10.1002/glia.20909 · Cited by 134
Discovery of Porcine microRNAs and Profiling from Skeletal Muscle Tissues during Development
Huang, T., Zhu, M., Li, X., & Zhao, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003225 · Cited by 131
Diagnostic Value of Cell-free Circulating Micrornas for Obesity and Type 2 Diabetes: A Meta-analysis
Villard, A., & Marchand, L. (2015) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.1000251 · Cited by 136
MicroRNA Biogenesis and Cancer
Winter, J. J., & Diederichs, S. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-863-8_1 · Cited by 130
Transcriptional Interferences in cis Natural Antisense Transcripts of Humans and Mice
Osato, N., Suzuki, Y., Ikeo, K., & Gojobori, T. (2007) · Genetics · doi:10.1534/genetics.106.069484 · Cited by 135
RNA viruses and the host microRNA machinery
tenOever, B. R. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2971 · Cited by 134
MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets
Klein, D., Misawa, R., Bravo-Egaña, V., Vargas, N., Rosero, S., Piroso, J., Ichii, H., Umland, O., Zhijie, J., Tsinoremas, N. F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055064 · Cited by 136
MicroRNAs preferentially target the genes with high transcriptional regulation complexity
Cui, Q., Yu, Z., Pan, Y., Purisima, E. O., & Wang, E. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.080 · Cited by 129
Rao, P. K., Missiaglia, E., Shields, L. Y., Hyde, G., Yuan, B., Shepherd, C. J., SHIPLEY, J. M., & Lodish, H. F. (2010) · The FASEB Journal · doi:10.1096/fj.09-150698 · Cited by 128
Agrawal, R., Tran, U., & Wessely, O. (2009) · Development · doi:10.1242/dev.037432 · Cited by 128
Predicting microRNA targeting efficacy in Drosophila
Agarwal, V., Subtelny, A. O., Thiru, P., Ulitsky, I., & Bartel, D. P. (2018) · Genome biology · doi:10.1186/s13059-018-1504-3 · Cited by 122
Goljanek‐Whysall, K., Sweetman, D., Abu-Elmagd, M. M., Chapnik, E., Dalmay, T., Hornstein, E., & Münsterberg, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105362108 · Cited by 127
Hagman, Z., Haflidadóttir, B. S., Ceder, J. A., Larne, O., Bjartell, A. S., Lilja, H. G., Edsjö, A., & Ceder, Y. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.131 · Cited by 128
Coller, H. A., Forman, J. J., & Legesse-Miller, A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030146 · Cited by 122
Spatial preferences of microRNA targets in 3' untranslated regions
Majoros, W. H., & Ohler, U. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-152 · Cited by 128
Altered expression of miRNA‐21 and its targets in the hippocampus after traumatic brain injury
Redell, J. B., Zhao, J., & Dash, P. K. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22539 · Cited by 121
MicroRNA pharmacogenomics: Post-transcriptional regulation of drug response
Rukov, J. L., & Shomron, N. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.04.003 · Cited by 124
Posttranscriptional control of neuronal development by microRNA networks
Gao, F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.10.004 · Cited by 119
Viader, A., Chang, L., Fahrner, T. J., Nagarajan, R., & Milbrandt, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3931-11.2011 · Cited by 123
Small but influential: the role of microRNAs on gene regulatory network and 3′UTR evolution
Zhang, R., & Su, B. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(09)60001-1 · Cited by 122
Kriegel, A. J., Fang, Y., Liu, Y., Tian, Z., Mladinov, D., Matus, I. R., Ding, X., Greene, A. S., & Liang, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq718 · Cited by 117
miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration
Staton, A. A., Knaut, H., & Giráldez, A. J. (2011) · Nature Genetics · doi:10.1038/ng.758 · Cited by 121
Otaegi, G., Pollock, A., Hong, J., & Sun, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4330-10.2011 · Cited by 115
Chen, K., & Rajewsky, N. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.039 · Cited by 117
Re‐thinking miRNA‐mRNA interactions: Intertwining issues confound target discovery
Cloonan, N. (2015) · BioEssays · doi:10.1002/bies.201400191 · Cited by 118
MicroRNAs of Bombyx mori identified by Solexa sequencing
Liu, S., Li, D., Li, Q., Zhao, P., Xiang, Z., & Xia, Q. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-148 · Cited by 111
A multi-targeted approach to suppress tumor-promoting inflammation
Samadi, A. K., Bilsland, A. E., Georgakilas, A. G., Amedei, A., Amin, A., Bishayee, A., Azmi, A. S., Lokeshwar, B. L., Grue, B., Panis, C., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.006 · Cited by 118
Coherent but overlapping expression of microRNAs and their targets during vertebrate developmentPreprint
Shkumatava, A., Stark, A., Sive, H. L., & Bartel, D. P. (2009) · Genes & Development · doi:10.1101/gad.1745709 · Cited by 114
Self-citationCnidarian microRNAs frequently regulate targets by cleavagePreprint
Moran, Y., Fredman, D., Praher, D., Li, X. Z., Wee, L. M., Rentzsch, F., Zamore, P. D., Technau, U., & Seitz, H. (2014) · Genome Research · doi:10.1101/gr.162503.113 · Cited by 113
The sufficient minimal set of miRNA seed types
Ellwanger, D. C., Büttner, F. A., Mewes, H.-W., & Stümpflen, V. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr149 · Cited by 112
Sõber, S., Laan, M., & Annilo, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.128 · Cited by 118
Chen, C., Ridzon, D., Lee, C.-T., Blake, J., Sun, Y. A., & Strauss, W. M. (2007) · Mammalian Genome · doi:10.1007/s00335-007-9032-6 · Cited by 112
Signatures of RNA binding proteins globally coupled to effective microRNA target sitesPreprint
Skanderup, A. J., Wen, J., Marks, D. S., & Krogh, A. (2010) · Genome Research · doi:10.1101/gr.103259.109 · Cited by 112
Yu, Z., Jian, Z., Shen, S., Purisima, E. O., & Wang, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl1032 · Cited by 109
miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation
Saxena, A., & Tabin, C. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912870107 · Cited by 108
D’Souza, A., Pearman, C. M., Wang, Y., Nakao, S., Logantha, S. J. R. J., Cox, C., Bennett, H. J., Zhang, Y., Johnsen, A. B., Linscheid, N., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.311607 · Cited by 110
MicroRNA-mediated control in the skin
Yi, R., & Fuchs, E. V. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.92 · Cited by 115
Interspecies regulation of microRNAs and their targets
Ha, M., Pang, M., Agarwal, V., & Chen, Z. J. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.03.004 · Cited by 112
miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate
Mann, M., Barad, O., Agami, R., Geiger, B., & Hornstein, E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915022107 · Cited by 109
Evolution of microRNAs and their targets: Are all microRNAs biologically relevant?
Axtell, M. J. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.02.007 · Cited by 109
Pancreas-enriched miRNA refines endocrine cell differentiation
Kredo‐Russo, S., Mandelbaum, A. D., Ness, A., Alon, I., Lennox, K. A., Behlke, M. A., & Hornstein, E. (2012) · Development · doi:10.1242/dev.080127 · Cited by 108
MicroRNAs Show Mutually Exclusive Expression Patterns in the Brain of Adult Male Rats
Olsen, L., Klausen, M., Helboe, L., Nielsen, F. C., & Werge, T. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007225 · Cited by 113
Computational Methods for MicroRNA Target Prediction
Watanabe, Y., Tomita, M., & Kanai, A. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)27004-1 · Cited by 113
EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors
Avraham, R., Sas‐Chen, A., Manor, O., Steinfeld, I., Shalgi, R., Tarcic, G., Moshe, N. B. B., Zeisel, A., Amit, I., Zwang, Y., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2000876 · Cited by 106
Xu, X., Li, Y., Wang, F., & Gao, F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4114-08.2008 · Cited by 104
MicroRNAs and ovarian function
Baley, J., & Li, J. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-8 · Cited by 104
Small RNA Detection by in Situ Hybridization Methods
Urbanek-Trzeciak, M. O., Nawrocka, A., & Krzyżosiak, W. J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160613259 · Cited by 108
MicroRNA Detection and Target Prediction: Integration of Computational and Experimental Approaches
Chaudhuri, K., & Chatterjee, R. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0549 · Cited by 103
Inferring MicroRNA Activities by Combining Gene Expression with MicroRNA Target Prediction
Cheng, C., & Li, L. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001989 · Cited by 100
Cheng, C., Fu, X., Alves, P., & Gerstein, M. (2009) · Genome biology · doi:10.1186/gb-2009-10-9-r90 · Cited by 103
Cheng, C., Yan, K., Hwang, W., Qian, J. X., Bhardwaj, N., Rozowsky, J. S., Lu, Z. J., Niu, W., Alves, P., Kato, M., et al. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002190 · Cited by 101
Small Regulatory RNAs May Sharpen Spatial Expression Patterns
Levine, E., McHale, P. T., & Levine, H. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030233 · Cited by 101
Hilgers, V., Bushati, N., & Cohen, S. M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000396 · Cited by 100
Self-citationA miRacle in plant development: Role of microRNAs in cell differentiation and patterning
Garcia, D. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.013 · Cited by 104
MicroRNAs and their roles in mammalian stem cells
Yi, R., & Fuchs, E. V. (2011) · Journal of Cell Science · doi:10.1242/jcs.069104 · Cited by 104
The miR-155–PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation
Lu, D., Nakagawa, R., Lazzaro, S., Staudacher, P., Abreu‐Goodger, C., Henley, T., Boiani, S., Leyland, R., Galloway, A., Andrews, S., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140338 · Cited by 106
A computational screen for mouse signaling pathways targeted by microRNA clusters
Xu, J., & Wong, C. (2008) · RNA · doi:10.1261/rna.997708 · Cited by 98
Sikand, K., Singh, J., Ebron, J. S., & Shukla, G. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047510 · Cited by 99
Hausser, J., Landthaler, M., Jaśkiewicz, Ł., Gaidatzis, D., & Zavolan, M. (2009) · Genome Research · doi:10.1101/gr.091181.109 · Cited by 99
Regulation of mammalian transcription and splicing by Nuclear RNAi
Kalantari, R., Chiang, C., & Corey, D. R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1305 · Cited by 100
MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
Chakraborty, C., Sharma, A. R., Patra, B. C., Bhattacharya, M., Sharma, G., & Lee, S. (2016) · Oncotarget · doi:10.18632/oncotarget.7977 · Cited by 100
Computational and transcriptional evidence for microRNAs in the honey bee genome
Weaver, D., Anzola, J. M., Evans, J. D., Reid, J. G., Reese, J., Childs, K. L., Zdobnov, E. M., Samanta, M. P., Miller, J., & Elsik, C. G. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-r97 · Cited by 96
Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cellsPreprint
Tan, J. Y., Sirey, T., Honti, F., Graham, B., Piovesan, A., Merkenschlager, M., Webber, C., Ponting, C. P., & Marques, A. C. (2015) · Genome Research · doi:10.1101/gr.181974.114 · Cited by 95
Fabbri, E., Borgatti, M., Montagner, G., Bianchi, N., Finotti, A., Lampronti, I., Bezzerri, V., Dechecchi, M. C., Cabrini, G., & Gambari, R. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0160oc · Cited by 94
Principles and Limitations of Computational MicroRNA Gene and Target Finding
Lindow, M., & Gorodkin, J. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0551 · Cited by 95
Functional screening identifies miR-315 as a potent activator of Wingless signaling
Silver, S. J., Hagen, J. W., Okamura, K., Perrimon, N., & Lai, E. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706673104 · Cited by 92
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression
Fabian, M. R., Sundermeier, T. R., & Sonenberg, N. (2009) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-03103-8_1 · Cited by 99
Clark, A., Goldstein, L. D., Tevlin, M., Tavaré, S., Shaham, S., & Miska, E. A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq083 · Cited by 95
PETERSON, K. J., SUMMONS, R. E., & DONOGHUE, P. C. J. (2007) · Palaeontology · doi:10.1111/j.1475-4983.2007.00692.x · Cited by 93
Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?
Aypar, U., Morgan, W. F., & Baulch, J. E. (2010) · International Journal of Radiation Biology · doi:10.3109/09553002.2010.522686 · Cited by 92
Denoising feedback loops by thresholding—a new role for microRNAs: Figure 1.Preprint
Cohen, S. M., Brennecke, J., & Stark, A. (2006) · Genes & Development · doi:10.1101/gad.1484606 · Cited by 94
Self-citationGuidi, M., Muiños-Gimeno, M., Kagerbauer, B., Martı́, E., Estivill, X., & Espinosa‐Parrilla, Y. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-95 · Cited by 91
Expression patterns of placental microRNAs
Mouillet, J., Chu, T., & Sadovsky, Y. (2011) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20782 · Cited by 90
Kreth, S., Limbeck, E., Hinske, L. C., Schütz, S. V., Thon, N., Hoefig, K. P., Egensperger, R., & Kreth, F. W. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1081-1 · Cited by 90
Bianchi, M., Renzini, A., Adamo, S., & Moresi, V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040840 · Cited by 90
microRNA control of cell-cell signaling during development and disease
Hagen, J. W., & Lai, E. C. (2008) · Cell Cycle · doi:10.4161/cc.6447 · Cited by 88
Aox gene structure, transcript variation and expression in plants
Polidoros, A. N., Mylona, P. V., & Arnholdt‐Schmitt, B. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01284.x · Cited by 88
Hypothesis: RNA editing of microRNA target sites in humans?
Liang, H., & Landweber, L. F. (2007) · RNA · doi:10.1261/rna.296407 · Cited by 88
General hallmarks of microRNAs in brain evolution and development
Chen, W., & Qin, C. (2015) · RNA Biology · doi:10.1080/15476286.2015.1048954 · Cited by 90
The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction
Tsurudome, K., Tsang, K., Liao, E. H., Ball, R., Penney, J., Yang, J.-S., Elazzouzi, F., He, T., Chishti, A., Lnenicka, G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.016 · Cited by 75
Towards computational prediction of microRNA function and activity
Ulitsky, I., Laurent, L. C., & Ron Shamir, A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq570 · Cited by 87
A quantitative RNA code for mRNA target selection by the germline fate determinant GLD‐1
Wright, J. E., Gaidatzis, D., Senften, M., Farley, B. M., Westhof, É., Ryder, S., & Ciosk, R. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.334 · Cited by 89
MicroRNAs and respiratory diseases
Rupani, H., Sánchez-Elsner, T., & Howarth, P. H. (2012) · European Respiratory Journal · doi:10.1183/09031936.00212011 · Cited by 87
Metadata
- Authors
- Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M.
- Affiliations
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Cohen, Stephen M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 123
- Issue
- 6
- Pages
- 1133-1146
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2034500416
- Cited by
- 1,080
- References
- 53
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 14 · 2023: 21 · 2022: 15 · 2021: 38 · 2020: 20 · 2019: 29 · 2018: 37 · 2017: 34 · 2016: 30 · 2015: 51 · 2014: 68 · 2013: 88 · 2012: 82
- FWCI
- 30.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2821 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, microRNA binding sites, post-transcriptional regulation, tissue-specific gene expression, co-expressed genes, cell lineage specification, tissue identity, non-coding RNA
- MeSH terms
- Animals, Base Sequence, Cell Line, Drosophila, Embryo, Nonmammalian, Membrane Proteins, Molecular Sequence Data, Muscles, Nerve Tissue Proteins, Nervous System, Nuclear Proteins, RNA, Messenger, Sequence Homology, Nucleic Acid, Tropomyosin, In Situ Hybridization, Homeodomain Proteins, Gene Expression Regulation, Developmental, Evolution, Molecular, 3' Untranslated Regions, Vacuolar Proton-Translocating ATPases, Drosophila Proteins, MicroRNAs, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
