The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Evolution of Adaptive Immune Systems
Open accessAbstract
A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led to the evolution of alternative ways for lymphocytes to generate diverse antigen receptors for use in recognizing and repelling pathogen invaders. All jawed vertebrates assemble their antigen-receptor genes through recombinatorial rearrangement of different immunoglobulin or T cell receptor gene segments. The surviving jawless vertebrates, lampreys and hagfish, instead solved the receptor diversification problem by the recombinatorial assembly of leucine-rich-repeat genetic modules to encode variable lymphocyte receptors. The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components.
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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
Transposition of hAT elements links transposable elements and V(D)J recombination
Zhou, L., Mitra, R., Atkinson, P. W., Burgess Hickman, A., Dyda, F., & Craig, N. L. (2004) · Nature · doi:10.1038/nature03157 · Cited by 224
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Metadata
- Authors
- Cooper, M. D., & Alder, M. N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 124
- Issue
- 4
- Pages
- 815-822
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1968191137
- Cited by
- 873
- References
- 4
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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