The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II
Open accessAbstract
Over the past years, a large number of histone posttranslational modifications have been described, some of which function to attain a repressed chromatin structure, while others facilitate activation by allowing access of regulators to DNA. Histone H2B monoubiquitination is a mark associated with transcriptional activity. Using a highly reconstituted chromatin-transcription system incorporating the inducible RARbeta2 promoter, we find that the establishment of H2B monoubiquitination by RNF20/40 and UbcH6 is dependent on the transcription elongation regulator complex PAF, the histone chaperone FACT, and transcription. H2B monoubiquitination facilitates FACT function, thereby stimulating transcript elongation and the generation of longer transcripts. These in vitro analyses and corroborating in vivo experiments demonstrate that elongation by RNA polymerase II through the nucleosomal barrier is minimally dependent upon (1) FACT and (2) the recruitment of PAF and the H2B monoubiquitination machinery.
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Citations
Cites
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Biological control through regulated transcriptional coactivators
Spiegelman, B. M., & Heinrich, R. (2004) · Cell · doi:10.1016/j.cell.2004.09.037 · Cited by 377
An, W., Palhan, V. B., Karymov, M. A., Leuba, S. H., & Roeder, R. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00497-5 · Cited by 100
Cited by
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
“A role for this modification has been demonstrated in transcriptional elongation by the histone chaperone FACT (Pavri et al., 2006).”
The complex language of chromatin regulation during transcription
Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768
Shilatifard, A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-134100 · Cited by 1,091
Self-citationHistones: annotating chromatin
Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852
Self-citationIs H3K4me3 instructive for transcription activation?
Howe, F. S., Fischl, H., Murray, S. C., & Mellor, J. (2017) · BioEssays · doi:10.1002/bies.201600095 · Cited by 513
Metadata
- Authors
- Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., & Reinberg, D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 125
- Issue
- 4
- Pages
- 703-717
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2014179038
- Cited by
- 707
- References
- 3
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S., Shilatifard, A., & Reinberg, D. (2006). Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II. Cell. https://doi.org/10.1016/j.cell.2006.04.029
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