Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches

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Items 301–400 of 476

  1. Interaction of Heat Shock Protein 90 and the Co-chaperone Cpr6 with Ura2, a Bifunctional Enzyme Required for Pyrimidine Biosynthesis*
    A. Zuehlke, Nicholas S. Wren, Victoria R. Tenge, Jill L. Johnson · 2013 · Journal of Biological Chemistry
  2. Diminished Ost3-dependent N-glycosylation of the BiP nucleotide exchange factor Sil1 is an adaptive response to reductive ER stress
    Kofi L. P. Stevens, Amy L. Black, Kelsi Wells, K. Y. Benjamin Yeo, Robert F. L. Steuart, Colin J. Stirling, Benjamin Luke Schulz, Carl J. Mousley · 2017 · Proceedings of the National Academy of Sciences
  3. Chaperone mediated detection of small molecule target binding in cells
    Kelvin Frank Cho, Taylur P. Ma, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake · 2020 · Nature Communications
  4. A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells
    Reine Hanna, Jad Abdallah, Thamara J. Abouantoun · 2021 · Frontiers in Oncology
  5. Many faces of a cancer-supporting protein
    John F. Darby, Paul Workman · 2011 · Nature
  6. The Hsp90 Molecular Chaperone Regulates the Transcription Factor Network Controlling Chromatin Accessibility
    Zlata Gvozdenov, Lindsey D. Bendix, Janhavi A. Kolhe, Brian Freeman · 2019 · Journal of Molecular Biology
  7. Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo
    Andrew W. Hoel, Peng Yu, Khanh P. Nguyen, XinXin Sui, Janet Plescia, Dario C. Altieri, Michael S. Conte · 2012 · American Journal Of Pathology
  8. Interplay of Structural Disorder and Short Binding Elements in the Cellular Chaperone Function of Plant Dehydrin ERD14
    Murvai, Nikoletta, Kalmar, Lajos, Szalaine Agoston, Bianka, Szabo, Beata, Tantos, Agnes, Csikos, Gyorgy, Micsonai, András, Kardos, József, Vertommen, Didier, Nguyen, Phuong N. et al. · 2020 · Cells
  9. Monitoring the Conformation of the Sba1/Hsp90 Complex in the Presence of Nucleotides with Mn(II)-Based Double Electron–Electron Resonance
    Angeliki Giannoulis, A. Feintuch, T. Unger, Shiran Amir, D. Goldfarb · 2021 · Journal of Physical Chemistry Letters
  10. Comparative RNA-sequencing analysis of ER-based HSP90 functions and signal pathways in Tribolium castaneum
    Wenfeng Xiong, Mengfan Zhai, Xiaojuan Yu, Luting Wei, Jinjuan Mao, Juanjuan Liu, Jia Xie, Bin Li · 2017 · Cell Stress and Chaperones
  11. Anti-dermatophytic activity of cold atmospheric plasma against Trichophyton rubrum via affecting fungal growth, morphology, drug susceptibility and HSP90 gene expression
    Asal Saf Samghabadi, Seyed-Mohammad Atyabi, Mehdi Razzaghi‐Abyaneh · 2022 · Scientific Reports
  12. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
    Yannick Weyer, Sinead Schwabl, Xuechen Tang, Astha Purwar, Konstantin Adrian Siegmann, Angela Ruepp, Theresia Dunzendorfer-Matt, Michael A. Widerin, Veronika Niedrist, Noa J M Mutsters et al. · 2024 · Nature Communications
  13. Exploring Mechanisms of Communication Switching in the Hsp90-Cdc37 Regulatory Complexes with Client Kinases through Allosteric Coupling of Phosphorylation Sites: Perturbation-Based Modeling and Hierarchical Community Analysis of Residue Interaction Networks
    Gabrielle Stetz, Lindy Astl, Gennady M. Verkhivker · 2020 · Journal of Chemical Theory and Computation
  14. Proteostatic stress as a nodal hallmark of replicative aging
    David F. Moreno, Martí Aldea · 2020 · Experimental Cell Research
  15. Cooperative Enhancement of Radiosensitivity After Combined Treatment of 17-(Allylamino)-17-Demethoxygeldanamycin and Celecoxib in Human Lung and Colon Cancer Cell Lines
    Young-Mee Kim, Hongryull Pyo · 2011 · DNA and Cell Biology
  16. Gene expression responses in different regions of Eisenia fetida with antiparasitic albendazole exposure
    Yuhong Gao, Xinsheng Sun, Xianrui Gu, Zhenjun Sun · 2013 · Ecotoxicology and Environmental Safety
  17. Synthesis and biological evaluation of geldanamycin analogs against human cancer cells
    Yanping Li, Jin-jing Chen, Jiajia Shen, Jing Cui, Linzhuan Wu, Zhen Wang, Zhuorong Li · 2015 · Cancer Chemotherapy and Pharmacology
  18. Evidence for interaction between Hsp90 and the ER membrane complex
    Tambudzai Kudze, Carlos Mendez‐Dorantes, Sallieu Jalloh, Amie Jo McClellan · 2018 · Cell Stress and Chaperones
  19. Perspectives on the specific targeting of Fusarium graminearum for the development of alternative head blight treatment approaches
    Miroslava Čuperlović‐Culf, Michèle C. Loewen, Nandhakishore Rajagopalan, Anuradha Surendra · 2017 · Plant Pathology
  20. Allosteric CDC37 Inhibitor Disrupts Chaperone Complex to Block CDK4/6 Maturation
    Lixiao Zhang, Wei Liu, Zhen Zheng, Qiuyue Zhang, Yanyi He, Jinying Gu, Danni Wang, Huangliang Shu, Jia Yu, Jianfeng Liu et al. · 2024 · Angewandte Chemie International Edition
  21. Disrupting progression of the yeast Hsp90 folding pathway at different transition points results in client-specific maturation defects
    Kaitlyn Hohrman, Davi Ludvig Gonçalves, Kevin A. Morano, Jill L. Johnson · 2021 · Genetics
  22. Simvastatin attenuates the c-Raf/Erk and calcineurin-NFATc2 pathways via inhibition of Hsp90 activity during the development of heart failure
    Tetsuro Marunouchi, Kyo Fujita, Kirara Takahashi, Shunsuke Namiki, Lina Kyo, Manami Uchida, Emi Yano, Kouichi Tanonaka · 2022 · Journal of Pharmacological Sciences
  23. MLL5 Maintains Genomic Integrity by Regulating the Stability of the Chromosomal Passenger Complex via a Functional Interaction with Borealin
    Jie Liu, Fei Cheng, Lih‐Wen Deng · 2012 · Journal of Cell Science
  24. Emergent Properties and Stability in Hierarchical Biosystems: There Is no Privileged Level of Causation
    Gustavo Maia Souza, Marcelo Nogueira do Amaral · 2019 · Springer eBooks
  25. Dynamic expression of rat heat shock protein gp96 and its gene during development of hepatocellular carcinoma.
    Xinhua Wu, Dengfu Yao, Xiaoqin Su, Bo-Jun Tai, Hua Huang, Liwei Qiu, Wei Wu, Yixiang Shao · 2007 · PubMed
  26. Targeting the cancer chaperone HSP90
    Jennifer R. Smith, Paul Workman · 2007 · Drug Discovery Today Therapeutic Strategies
  27. Molecular chaperones
    Edward E. Melnikov, Tatyana V. Rotanova · 2010 · Russian Journal of Bioorganic Chemistry
  28. Regulatory Variants Drive Hsp90's Effect on Adaptation
    Christopher M. Jakobson, José Aguilar-Rodríguez, Daniel F. Jarosz · 2023 · SSRN Electronic Journal
  29. Computational Modeling of the Hsp90 Interactions with Cochaperones and Small-Molecule Inhibitors
    Gennady M. Verkhivker · 2017 · Methods in molecular biology
  30. Programmed Trade-offs in Protein Folding Networks
    Sebastian Pechmann · 2020 · Structure
  31. Regulation of Protein Transport Pathways by the Cytosolic Hsp90s
    Anna G. Mankovich, Brian Freeman · 2022 · Biomolecules
  32. Proteostatic tuning underpins the evolution of novel multicellular traits
    Kristopher Montrose, Dung T. Lac, Anthony Burnetti, Kai Tong, Gonensin Ozan Bozdag, Mikaela Hukkanen, William C. Ratcliff, Juha Saarikangas · 2024 · Science Advances
  33. Protozoan HSP90-Heterocomplex: Molecular Interaction Network and Biological Significance
    María J. Figueras, Pablo C. Echeverría, Sergio Oscar Angel · 2014 · Current Protein and Peptide Science
  34. The Interplay Between Proteostasis Systems and Parkinson’s Disease
    Diana F. Lázaro, Tiago F. Outeiro · 2020 · Advances in experimental medicine and biology
  35. Identification and Characterization of Three Heat Shock Protein 90 (Hsp90) Homologs in the Brown Planthopper
    Xuan Chen, Ze‐Dong Li, Yi‐Ting Dai, Mingxing Jiang, Chuan‐Xi Zhang · 2020 · Genes
  36. Differential expression of heat-shock proteins Hsp70 and Hsp90 in vegetative and reproductive tissues of Iris pumila
    Sanja Jovanović, Branka Tucić, Gordana M. Matić · 2010 · Acta Physiologiae Plantarum
  37. A Preliminary in vitro and in vivo Evaluation of the Effect and Action Mechanism of 17-AAG Combined With Azoles Against Azole-Resistant Candida spp.
    Luyao Liu, Xueying Zhang, Shruti Kayastha, Lihua Tan, Heng Zhang, Jingwen Tan, Linyun Li, Jinghua Mao, Yi Sun · 2022 · Frontiers in Microbiology
  38. Hsp90-Mediated Multi-Drug Resistance in DNA Polymerase-Defective Strains of Candida albicans
    Bhabasha Gyanadeep Utkalaja, Satya Ranjan Sahu, Sushree Subhashree Parida, Narottam Acharya · 2024 · Journal of Fungi
  39. The Ribosomal Biogenesis Protein Utp21 Interacts with Hsp90 and Has Differing Requirements for Hsp90-Associated Proteins
    Victoria R. Tenge, Knowles Jared, Jill L. Johnson · 2014 · PLoS ONE
  40. New Insights Into Heat Shock Protein 90 in the Pathogenesis of Pulmonary Arterial Hypertension
    Liqing Hu, Rui Zhao, Qinglian Liu, Qianbin Li · 2020 · Frontiers in Physiology
  41. Inhibition of HSP90 causes morphological variation in the invasive ant Cardiocondyla obscurior
    Lukas Schrader, Miles Winter, Mohammed Errbii, Jacques Hubert Charles Delabie, Jan Oettler, Jürgen R. Gadau · 2021 · Journal of Experimental Zoology Part B Molecular and Developmental Evolution
  42. The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective
    José Aguilar-Rodríguez, Christopher M. Jakobson, Daniel F. Jarosz · 2024 · Journal of Molecular Biology
  43. The Therapeutic Roles of Recombinant Hsp90α on Cornea Epithelial Injury
    Mingli Wang, Jialin Hu, Junwei Qu, Huili Huang, Jing Zhang, Jun Zhang, Hui Li, Xiukun Cui, Fengyan Zhang, Meng Yue Hu et al. · 2022 · Investigative Ophthalmology & Visual Science
  44. Allosteric Mechanism of the Hsp90 Chaperone Interactions with Cochaperones and Client Proteins by Modulating Communication Spines of Coupled Regulatory Switches: Integrative Atomistic Modeling of Hsp90 Signaling in Dynamic Interaction Networks
    Lindy Astl, Gabrielle Stetz, Gennady M. Verkhivker · 2020 · Journal of Chemical Information and Modeling
  45. A Single Site Phosphorylation on Hsp82 Ensures Cell Survival during Starvation in Saccharomyces cerevisiae
    Xuan Shang, Guang Cao, Han Jie Gao, Melinda M. Li, Guanzu Peng, Yanqiu Ji, Yansong Zhang, Wenzhe Zhang, Wanjie Li, Fei Dou · 2020 · Journal of Molecular Biology
  46. Cloning, purification and characterization of a 90kDa heat shock protein from Citrus sinensis (sweet orange)
    Yuri A. Mendonça, Carlos H.I. Ramos · 2011 · Plant Physiology and Biochemistry
  47. Identification of Hsp90 as a species independent H5N1 avian influenza A virus PB2 interacting protein
    Krit Jirakanwisal, Kanjana Srisutthisamphan, Chutima Thepparit, Ornpreya Suptawiwat, Prasert Auewarakul, Atchara Paemanee, Sittiruk Roytrakul, Duncan Richard Smith · 2015 · Comparative Immunology Microbiology and Infectious Diseases
  48. Mechanism of Inhibition of Hsp90 Dimerization by Gyrase B Inhibitor Coumermycin A1 (C–A1) Revealed by Molecular Dynamics Simulations and Thermodynamic Calculations
    Favourite Nontando. Cele, Hezekiel Mathambo Kumalo, Mahmoud E. S. Soliman · 2016 · Cell Biochemistry and Biophysics
  49. Insights into Hsp90 mechanism and in vivo functions learned from studies in the yeast, Saccharomyces cerevisiae
    Rios, Erick I., Hunsberger, Isabel L., Johnson, Jill L. · 2024 · Frontiers in Molecular Biosciences
  50. Role of heat shock protein in radiation-induced effect and related potential clinical application
    Ying Xu, Wentao Hu, Guangming Zhou · 2024 · Radiation Medicine and Protection
  51. Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule
    Edyta Petters, Aleksandra Sokołowska-Wędzina, Jacek Otlewski · 2015 · International Journal of Molecular Sciences
  52. Identification and Characterization ofTheileria annulataHeat-Shock Protein 90 (HSP90) Isoforms
    Sara B. Mohammed, Mohammed Ahmed Bakheit, M. Ernst, Jabbar Sabir Ahmed, Ulrike Seitzer · 2013 · Transboundary and Emerging Diseases
  53. Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery
    Nathan Lawless, Kristin M. Blacklock, Elizabeth Berrigan, Gennady M. Verkhivker · 2013 · Pharmaceuticals
  54. In vitro interactions between 17‐ AAG and azoles against Exophiala dermatitidis
    Lujuan Gao, Yi Sun, Chengyan He, Ming Li, Tongxiang Zeng · 2018 · Mycoses
  55. Native Size-Exclusion Chromatography–Based Mass Spectrometry Reveals New Components of the Early Heat Shock Protein 90 Inhibition Response Among Limited Global Changes
    Rahul S. Samant, Sílvia Batista, Mark Larance, Buğra Özer, Christopher I. Milton, Isabell Bludau, Estelle Wu, Laura Biggins, Simon Andrews, Alexia Hervieu et al. · 2022 · Molecular & Cellular Proteomics
  56. “Spear and shield in one” nanochaperone enables protein to navigate multiple biological barriers for enhanced tumor synergistic therapy
    Xiaoxiao Zhang, Da‐Yuan Wang, Xiaohui Wu, Yu Zhao, Xue Li, Rujiang Ma, Fan Huang, Linqi Shi · 2022 · Biomaterials Science
  57. Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells
    Yu‐Jia Chang, Chien‐Yu Huang, Chin‐Sheng Hung, Hui-Hsiung Liu, Po‐Li Wei · 2015 · Tumor Biology
  58. The Role of Heat Shock Proteins in Mammary Neoplasms: A Brief Review
    Leonardo Della Salda, Mariarita Romanucci · 2012 · Journal of Cancer Therapy
  59. Exploring the Nucleolar Proteome: Novel Concepts for Chaperone Trafficking and Function
    Piotr Banski, Mohamed Kodiha, Ursula Stochaj · 2011 · Current Proteomics
  60. The Unmysterious Roles of HSP90: Ovarian Pathology and Autoantibodies
    Eusebio S. Pires · 2017 · Advances in anatomy, embryology and cell biology
  61. Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae
    Tong Zhang, Yuping Lin, Ziteng Zhang, Zhen Wang, Fanli Zeng, Qinhong Wang · 2025 · FEBS Journal
  62. Recent progress in the development of HSP90 inhibitors: structure–activity relationship and biological evaluation studies
    Ankush Kumar, Aman Rai, Naresh Kumar Rangra, Thakur Gurjeet Singh, Samson Chibuzo Ugwuagbo, Rohit Bhatia · 2025 · Molecular Diversity
  63. Quantitative proteomic analysis reveals unique Hsp90 cycle-dependent client interactions
    Erick I. Rios, Davi Ludvig Gonçalves, Kevin A. Morano, Jill L. Johnson · 2024 · Genetics
  64. Simvastatin and rosuvastatin attenuate necroptosis in rat failing hearts following myocardial infarction; the contribution of Hsp90 inhibition in cardiomyocytes to prevent necroptosis
    Tetsuro Marunouchi, Kasumi Matsumura, Kaho Sato, Shiori Takeuchi, Takuma Murakami, Kouichi Tanonaka · 2025 · Biochemical Pharmacology
  65. hsp-90 and unc-45 depletion induce characteristic transcriptional signatures in coexpression cliques of C. elegans
    Lukas Schmauder, Klaus Richter · 2021 · Scientific Reports
  66. Profiling of Brevibacillus borstelensis transcriptome exposed to high temperature shock
    Seema Tripathy, Soumesh Kumar Padhi, Rinil Sen, S. Mohanty, Mrinal Samanta, Nikhil Kumar Maiti · 2015 · Genomics
  67. Mutant-selective topologic conversion facilitates selective degradation of a pathogenic prion isoform
    Yu‐Mi Lee, Hongsik Eum, Duri Lee, Sohee Lee, Youngsup Song, Sang‐Wook Kang · 2019 · Cell Death and Differentiation
  68. Promotion of Hyperthermic-Induced rDNA Hypercondensation in Saccharomyces cerevisiae
    Donglai Shen, Robert V. Skibbens · 2020 · Genetics
  69. Hsp90 interaction with Cdc2 and Plo1 kinases contributes to actomyosin ring condensation in fission yeast
    Andrea Santino, Víctor A. Tallada, Juan Jiménez, Andrés Garzón · 2012 · Current Genetics
  70. Twin Layers of Lightning
    Xinchun Pi, Cam Patterson · 2007 · Arteriosclerosis Thrombosis and Vascular Biology
  71. Non-enzymatic protein targeting agents as a promising strategy for cancer treatment
    Madison Ambrose, Jeremy Lee, Aleem Syed, Zamal Ahmed, Guang Peng · 2025 · Frontiers in Drug Discovery
  72. Oxidative stress, DNA damage, and gene expression in earthworms (Eisenia fetida) exposure to ethiprole
    Min Zhou, Caixia Zhang, Fuhao Wang, Peipei Hao, 刘子琦, Youpu Cheng · 2024 · Environmental Science and Pollution Research
  73. Visualizing Single-Molecule Protein Conformational Transitions and Free Energy Landscape
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  74. Proteostasis is a key driver of the pathogenesis in Apicomplexa
    Pallabi Mitra, Abhijit S. Deshmukh · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  75. Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity
    Blanca Fernandez-Ciruelos, Marco Albanese, Anmol S. Adhav, Vitalii V. Solomin, Arabela Ritchie-Martinez, Femke J. Taverne, Nadya Velikova, Aigars Jirgensons, Alberto Marina, Paul W. Finn et al. · 2024 · Microbiology Spectrum
  76. Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function
    Melody D. Fulton, Danielle Yama, Ella Dahl, Jill L. Johnson · 2024 · PLoS Genetics
  77. Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells
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  78. Chemogenomic Analysis Identifies Macbecin II as a Compound Specific for SMAD4‐Negative Colon Cancer Cells
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  79. Computational Studies of Allosteric Regulation in the Hsp90 Molecular Chaperone: From Functional Dynamics and Protein Structure Networks to Allosteric Communications and Targeted Anti‐Cancer Modulators
    Gennady M. Verkhivker · 2014 · Israel Journal of Chemistry
  80. Gene expression and molecular characterization of a chaperone protein HtpG from Bacillus licheniformis
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  81. A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways
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  82. Dissecting Molecular Principles of the Hsp90 Chaperone Regulation by Allosteric Modulators Using a Hierarchical Simulation Approach and Network Modeling of Allosteric Interactions: Conformational Selection Dictates the Diversity of Protein Responses and Ligand-Specific Functional Mechanisms
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  83. Plasma Heat Shock Protein 90 Levels in Patients with Spondyloarthritis and Their Relation to Structural Changes: A Cross-Sectional Study
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  84. Immense Cellular Implications Associated to Small Stress Proteins Expression: Impacts on Human Pathologies
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  85. Glutaminyl cyclase inhibitor contributes to the regulation of HSP70, HSP90, actin, and ribosome on gene and protein levels in vitro
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  86. Effects of a combined treatment regimen consisting of Hsp90 inhibitor DS-2248 and radiation in vitro and in a tumor mouse model
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  90. Targeted proteomics identify metabolism-dependent interactors of yeast cytochrome c peroxidase: implications in stress response and heme trafficking
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  91. Extracellular HSP90α Versus Intracellular HSP90β in Wound Healing and Cancer
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  92. Updates on Aβ Processing by Hsp90, BRICHOS, and Newly Reported Distinctive Chaperones
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  93. The Role of Sgt1 in Methamphetamine/Hyperthermia-induced Necroptosis
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  94. Selection of ethanol tolerant strains of Candida albicans by repeated ethanol exposure results in strains with reduced susceptibility to fluconazole
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  96. CELLULAR TARGET ENGAGEMENT ASSAYS FOR SMALL-MOLECULE DRUG DISCOVERY
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  97. The Interaction Network of the Hsp90 Molecular Chaperone
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  98. Evaluating Dual Hsp90 and Hsp70 Inhibition as a Cancer Therapy
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  99. The ataxia protein sacsin is required for integrin trafficking and synaptic organization
    Lisa E. L. Romano, Wen Yih Aw, Kathryn M. Hixson, Tatiana V. Novoselova, Tammy M. Havener, Stefanie Howell, Charlotte Louise Hall, Lei Xing, Joshua Beri, Suran Nethisinghe et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  100. Yeast require an Intact Tryptophan Biosynthesis Pathway and Exogenous Tryptophan for Resistance to Sodium Dodecyl Sulfate
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