Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches

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Items 201–300 of 476

  1. Chaperone Networks in Fungal Pathogens of Humans
    Linda C. Horianopoulos, James W. Kronstad · 2021 · Journal of Fungi
  2. Organismal Roles of Hsp90
    Patricija van Oosten‐Hawle · 2023 · Biomolecules
  3. Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway
    David I. Duron, Wei Lei, Natalie K. Barker, Carrie Stine, Sanket J. Mishra, Brian S. J. Blagg, Paul R. Langlais, John M. Streicher · 2020 · Science Signaling
  4. Structure-guided approaches to targeting stress responses in human fungal pathogens
    Emmanuelle V. LeBlanc, Elizabeth J. Polvi, Amanda O. Veri, Gilbert G. Privé, Leah E. Cowen · 2020 · Journal of Biological Chemistry
  5. The expanding proteome of the molecular chaperone HSP90
    Rahul S. Samant, Paul Andrew Clarke, Paul Workman · 2012 · Cell Cycle
  6. The Role of p23, Hop, Immunophilins, and Other Co-chaperones in Regulating Hsp90 Function
    Marc B. Cox, Jill L. Johnson · 2011 · Methods in molecular biology
  7. p23 and Aha1
    Alexandra Rehn, Johannes Büchner · 2014 · Sub-cellular biochemistry/Subcellular biochemistry
  8. HSP90 Controls SIR2 Mediated Gene Silencing
    Shyamasree Laskar, Mrinal Kanti Bhattacharyya, Rama Shankar, Sunanda Bhattacharyya · 2011 · PLoS ONE
  9. Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone
    Agnieszka Góral, Paweł Bieganowski, Wiktor Prus, Łucja Krzemień‐Ojak, Beata Kądziołka, Hanna Fabczak, Anna Filipek · 2016 · PLoS ONE
  10. Comprehensive Profiling of Lysine Acetylome in Baculovirus Infected Silkworm (Bombyx mori) Cells
    Dongbing Hu, Shengjie Xue, Cui Zhao, Ming Wei, Huihui Yan, Yanping Quan, Wei Yu · 2017 · PROTEOMICS
  11. The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers
    Joseph Newman, Amin S. Asfor, Stephen Berryman, Terry Jackson, Stephen Curry, Tobias J. Tuthill · 2017 · Journal of Virology
  12. A Human Lectin Microarray for Sperm Surface Glycosylation Analysis
    Yangyang Sun, Li Ting Cheng, Yihua Gu, Aijie Xin, Bin Wu, Shumin Zhou, Shujuan Guo, Yin Liu, Hua Diao, Huijuan Shi et al. · 2016 · Molecular & Cellular Proteomics
  13. Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription
    Kay Y. Chong, Min Kang, Francesca Garofalo, Daiki Ueno, Huamao Liang, Sarah L. Cady, Oluwagbemisola Madarikan, Nicholas Pitruzzello, Cheng-Hsiu Tsai, Tobias M.P. Hartwich et al. · 2019 · Molecular Pharmacology
  14. Chaperome Networks – Redundancy and Implications for Cancer Treatment
    Pengrong Yan, Tai Wang, Mónica L. Guzmán, Ioan Radu Peter, Gabriela Chiosis · 2020 · Advances in experimental medicine and biology
  15. The Hsp90-Dependent Proteome Is Conserved and Enriched for Hub Proteins with High Levels of Protein–Protein Connectivity
    Rajaneesh Karimpurath Gopinath, Shu‐Ting You, Kun‐Yi Chien, Krishna B. S. Swamy, Jau‐Song Yu, Scott C. Schuyler, Jun‐Yi Leu · 2014 · Genome Biology and Evolution
  16. Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
    Matea Perić, Peter Bou Dib, Sven Dennerlein, Marina Musa, Marina Rudan, Anita Lovrić, Andrea Nikolić, Ana Šarić, Sandra Sobočanec, Željka Mačak Šafranko et al. · 2016 · Scientific Reports
  17. The known unknowns of the Hsp90 chaperone
    Laura‐Marie Silbermann, Benjamin Vermeer, Sonja Schmid, Katarzyna M. Tych · 2024 · eLife
  18. Molecular chaperones biochemistry and role in neurodegenerative diseases
    Ali Châari · 2019 · International Journal of Biological Macromolecules
  19. Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1
    А. В. Антонова, Barbara Hummel, Ashkan Khavaran, Desiree Melanie Redhaber, Fernando Aprile-Garcia, Prashant Rawat, Kathrin Gundel, Megan Schneck, Erik C Hansen, Jan Mitschke et al. · 2019 · Cell Reports
  20. Hsp90 as a Potential Therapeutic Target in Retinal Disease
    Mònica Aguilà, Michael E. Cheetham · 2015 · Advances in experimental medicine and biology
  21. Puupehenone, a Marine-Sponge-Derived Sesquiterpene Quinone, Potentiates the Antifungal Drug Caspofungin by Disrupting Hsp90 Activity and the Cell Wall Integrity Pathway
    Siddharth Tripathi, Qin Fu Feng, Li Liu, David E. Levin, Kuldeep Kumar Roy, Robert J. Doerksen, Scott R. Baerson, Xiaomin Shi, Xuewen Pan, Wenhui Xu et al. · 2020 · mSphere
  22. Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology
    Diane C. Munday, Gareth J. Howell, John N. Barr, Julian A. Hiscox · 2014 · Journal of Pharmacy and Pharmacology
  23. Proteomic and Phosphoproteomic Analyses of the Soluble Fraction following Acute Spinal Cord Contusion in Rats
    Anshu Chen, Melanie L. McEwen, Shixin Sun, R. Ravikumar, Joe E. Springer · 2009 · Journal of Neurotrauma
  24. Both the Charged Linker Region and ATPase Domain of Hsp90 Are Essential for Rad51-Dependent DNA Repair
    Tanvi Suhane, Shyamasree Laskar, Siddheshwari Advani, Nabamita Roy, Shalu M. Varunan, Dibyendu Bhattacharyya, Sunanda Bhattacharyya, Mrinal Kanti Bhattacharyya · 2014 · Eukaryotic Cell
  25. Antifungal Drugs: The Current Armamentarium and Development of New Agents
    Nicole Robbins, Gerard D. Wright, Leah E. Cowen · 2017 · ASM Press eBooks
  26. Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52
    Rein, Theo · 2020 · BioEssays
  27. A G protein–coupled receptor and the intracellular synthase of its agonist functionally cooperate
    Chantal Binda, Samuel Génier, Andréane Cartier, Jean‐François Larrivée, Jana Staňková, Jason C. Young, Jean‐Luc Parent · 2014 · The Journal of Cell Biology
  28. Network Theoretical Approach to Explore Factors Affecting Signal Propagation and Stability in Dementia’s Protein-Protein Interaction Network
    Amit Kumar Lalwani, Kushagra Krishnan, Sali Abubaker Bagabir, Mustfa Alkhanani, Atiah H. Almalki, Shafiul Haque, Saurabh Kumar Sharma, R. K. Brojen Singh, Md. Zubbair Malik · 2022 · Biomolecules
  29. Analysis of the prognostic, diagnostic and immunological role of HSP90α in malignant tumors
    Zhimin Yuan, Longhao Wang, Cheng Yeh Chen · 2022 · Frontiers in Oncology
  30. Hsp90 in non-mammalian metazoan model systems
    Veronika Haslbeck, Christoph J. O. Kaiser, Klaus Richter · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  31. The Anticancer Drug AUY922 Generates a Proteomics Fingerprint That Is Highly Conserved among Structurally Diverse Hsp90 Inhibitors
    Sudhakar Voruganti, Jeff C. LaCroix, Chelsea N. Rogers, Janet Rogers, Robert L. Matts, Steven D. Hartson · 2013 · Journal of Proteome Research
  32. Hsp90 and mitochondrial proteases Yme1 and Yta10/12 participate in ATP synthase assembly in Saccharomyces cerevisiae
    Brian R. Francis, Peter E. Thorsness · 2011 · Mitochondrion
  33. Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia
    Kalubai Vari Khajapeer, Baskaran Rajasekaran · 2015 · Leukemia Research and Treatment
  34. OsGRF4AA compromises heat tolerance of developing pollen grains in rice
    Yujian Mo, Guangyan Li, Li Liu, Yingjie Zhang, Junyi Li, Meizhen Yang, Shanlan Chen, Qiaoling Lin, Guanfu Fu, Dianfeng Zheng et al. · 2023 · Frontiers in Plant Science
  35. Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis
    Yasmine Draceni, Sebastian Pechmann · 2019 · Proceedings of the National Academy of Sciences
  36. Protein Complexes Form a Basis for Complex Hybrid Incompatibility
    Krishna B. S. Swamy, Scott C. Schuyler, Jun‐Yi Leu · 2021 · Frontiers in Genetics
  37. Biogenesis of RNA Polymerases in Yeast
    Ana Isabel Garrido-Godino, Francisco Gutiérrez-Santiago, Francisco Navarro · 2021 · Frontiers in Molecular Biosciences
  38. Experimentally Guided Structural Modeling and Dynamics Analysis of Hsp90–p53 Interactions: Allosteric Regulation of the Hsp90 Chaperone by a Client Protein
    Kristin M. Blacklock, Gennady M. Verkhivker · 2013 · Journal of Chemical Information and Modeling
  39. Hsp90, a team player in protein quality control and the stress response in bacteria
    Anushka C. Wickramaratne, Sue Wickner, Andrea N. Kravats · 2024 · Microbiology and Molecular Biology Reviews
  40. The Saccharomyces cerevisiae Hot1p regulated gene YHR087W (HGI1) has a role in translation upon high glucose concentration stress
    Mercè Gomar‐Alba, Elena Jiménez-Martí, Marcel·lí del Olmo · 2012 · BMC Molecular Biology
  41. Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression: An Update
    André‐Patrick Arrigo · 2012 · Scientifica
  42. Proteomic Characterization of Aspergillus fumigatus Treated with an Antifungal Coumarin for Identification of Novel Target Molecules of Key Pathways
    Seema Singh, Shilpi Gupta, Bharat Singh, Sunil Kumar Sharma, Vijay K. Gupta, Gainda L. Sharma · 2012 · Journal of Proteome Research
  43. Functional Role and Hierarchy of the Intermolecular Interactions in Binding of Protein Kinase Clients to the Hsp90–Cdc37 Chaperone: Structure-Based Network Modeling of Allosteric Regulation
    Gabrielle Stetz, Gennady M. Verkhivker · 2018 · Journal of Chemical Information and Modeling
  44. Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats
    Tetsuro Marunouchi, Takumi Ito, Sumika Onda, Lina Kyo, Kirara Takahashi, Manami Uchida, Emi Yano, Kouichi Tanonaka · 2021 · Journal of Pharmacological Sciences
  45. How do plants cope with oxidative stress in nature? A study on the dwarf bearded iris (Iris pumila)
    Ana Vuleta, Sanja Jovanović, Branka Tucić · 2014 · Acta Physiologiae Plantarum
  46. Differences in the Ovine HSP90AA1 Gene Expression Rates Caused by Two Linked Polymorphisms at Its Promoter Affect Rams Sperm DNA Fragmentation under Environmental Heat Stress Conditions
    Judit Salces-Ortiz, Manuel Ramón, Carmen González, M. Dolores Pérez-Guzmán, José Julián Garde, Olga García‐Álvarez, Alejandro Maroto-Morales, J. H. Calvo, M. Serrano · 2015 · PLoS ONE
  47. Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery
    Vikram Narayan, Mirjam J Eckert, Maciej Żylicz, Maciej Żylicz, Kathryn L. Ball · 2009 · Journal of Biological Chemistry
  48. A comparative analysis of DNA barcode microarray feature size
    Ron Ammar, Andrew M Smith, Lawrence E. Heisler, Guri N. Giaever, Corey Nislow · 2009 · BMC Genomics
  49. Rng3, a member of the UCS family of myosin co‐chaperones, associates with myosin heavy chains cotranslationally
    Maria João Amorim, Juan Mata · 2008 · EMBO Reports
  50. Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design
    Gennady M. Verkhivker, Anshuman Dixit, Giulia Morra, Giorgio Colombo · 2009 · Current Topics in Medicinal Chemistry
  51. Comparative Transcriptome Analysis Reveals the Potential Mechanism of Abortion in Tobacco sua-Cytoplasmic Male Sterility
    Zhiwen Liu, Yanfang Liu, Yuhe Sun, Aiguo Yang, Fengxia Li · 2020 · International Journal of Molecular Sciences
  52. Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14
    Nikoletta Murvai, Lajos Kalmár, Beáta Szabó, Éva Schád, András Micsonai, József Kardos, László Buday, Kyou‐Hoon Han, Péter Tompa, Ágnes Tantos · 2021 · International Journal of Molecular Sciences
  53. Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae
    Gary A. Flom, Ewa Langner, Jill L. Johnson · 2012 · Current Genetics
  54. Novel insights into molecular chaperone regulation of ribonucleotide reductase
    Laura E. Knighton, Lena E. Delgado, Andrew W. Truman · 2018 · Current Genetics
  55. Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo
    Katharina Ernst, Ann‐Katrin Mittler, Veronika Eva Winkelmann, Carolin Kling, Nina Eberhardt, Anna Anastasia, Michael Sonnabend, Robin Lochbaum, Jan Wirsching, Moona Sakari et al. · 2021 · Scientific Reports
  56. Suppressing the CDC 37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth
    Zhanhui Wang, Wei Wei, Chris Kin-Wai Sun, Mei‐Sze Chua, Samuel K. So · 2014 · Liver International
  57. Chaperone–client complexes: A dynamic liaison
    Sebastian Hiller, Björn M. Burmann · 2018 · Journal of Magnetic Resonance
  58. Dynamics-based community analysis and perturbation response scanning of allosteric interaction networks in the TRAP1 chaperone structures dissect molecular linkage between conformational asymmetry and sequential ATP hydrolysis
    Gennady M. Verkhivker · 2018 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  59. Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms
    Steven De Almeida, Mathilde Regimbeau, Gaëtan Jégo, Carmen Garrido, François Girodon, François Hermetet · 2020 · Cancers
  60. Regulation of chaperone gene expression by heat shock transcription factor inSaccharomyces cerevisiae: Importance in normal cell growth, stress resistance, and longevity
    Hiroshi Sakurai, Azumi Ota · 2011 · FEBS Letters
  61. Molecular Chaperones: Structure-Function Relationship and their Role in Protein Folding
    Bhaskar K. Chatterjee, Sarita Puri, Ashima K. Sharma, Ashutosh Pastor, Tapan K. Chaudhuri · 2018 · Heat shock proteins
  62. Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity
    Yukiko Takemori, Yasuaki Enoki, Noritaka Yamamoto, Yo Fukai, Kaori Adachi, Hiroshi Sakurai · 2009 · Biochemical Journal
  63. Gedunin Binds to Myeloid Differentiation Protein 2 and Impairs Lipopolysaccharide-Induced Toll-Like Receptor 4 Signaling in Macrophages
    Perla Villani Borges, Katelim Hottz Moret, Clarissa M. Maya‐Monteiro, Franklin Souza‐Silva, Carlos Roberto Alves, Paulo Ricardo Batista, Ernesto R. Caffarena, Patrícia Pacheco, Maria das Graças Henriques, Carmen Penido · 2015 · Molecular Pharmacology
  64. Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding
    Marc B. Cox, Jill L. Johnson · 2017 · Methods in molecular biology
  65. Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives
    Ghosh, Arnab, Stuehr, Dennis J. · 2017 · Antioxidants & Redox Signaling
  66. Antiviral evaluation of an Hsp90 inhibitor, gedunin, against dengue virus
    Deeba Amraiz, Najam‐us‐Sahar Sadaf Zaidi, Munazza Tamkeen Fatima · 2017 · Tropical Journal of Pharmaceutical Research
  67. Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization
    Lisa E. L. Romano, Wen Yih Aw, Kathryn M. Hixson, Tatiana V. Novoselova, Tammy M. Havener, Stefanie Howell, Bonnie Taylor‐Blake, Charlotte Louise Hall, Lei Xing, Joshua Beri et al. · 2022 · Cell Reports
  68. Incorporating gene ontology into fuzzy relational clustering of microarray gene expression data
    Animesh Kumar Paul, Pintu Chandra Shill · 2017 · Biosystems
  69. A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production
    Madeline Y. Wong, Ngoc Duc Doan, Andrew S. DiChiara, Louis J. Papa, Jaime H. Cheah, Christian K. Soule, Nicki Watson, John D. Hulleman, Matthew D. Shoulders · 2018 · Biochemistry
  70. Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target
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  71. HSP90 as a novel therapeutic target for posterior capsule opacification
    Jing Li, Wenxian Xue, Xuance Wang, Weikang Huang, Xiangxiang Wang, Hui Li, Xiukun Cui, Mengyuan Li, Hongmei Mu, Yan-Zhu Ren et al. · 2019 · Experimental Eye Research
  72. The Heat Shock Connection of Metabolic Stress and Dietary Restriction
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  73. The Nuclear and DNA-Associated Molecular Chaperone Network
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  74. ATP Impedes the Inhibitory Effect of Hsp90 on Aβ40 Fibrillation
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  75. Heat-activated nanomedicine formulation improves the anticancer potential of the HSP90 inhibitor luminespib in vitro
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  76. Involvement of Hsp90 in NLRP3 inflammasome activation in the failing heart following myocardial infarction in rats
    Tetsuro Marunouchi, Aika Iguchi, Aono Shindo, Nana Shimbo, Emi Yano, Kouichi Tanonaka · 2023 · Biochemical Pharmacology
  77. Conformational and functional studies of a cytosolic 90 kDa heat shock protein Hsp90 from sugarcane
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  78. A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones
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  79. Toxoplasma gondiiHsp90: potential roles in essential cellular processes of the parasite
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  80. GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA
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  81. How and why do toxic conformers of aberrant proteins accumulate during ageing?
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  82. PRDM14 directly interacts with heat shock proteins HSP90α and glucose‐regulated protein 78
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  83. Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-κB Activation in Human Myeloid Leukemia THP-1 Cells
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  84. Hsp90 Inhibitor Attenuates the Development of Pathophysiological Cardiac Fibrosis in Mouse Hypertrophy via Suppression of the Calcineurin-NFAT and c-Raf-Erk Pathways
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  85. BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation
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  86. Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
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  87. In vitro and in vivo Study of Antifungal Effect of Pyrvinium Pamoate Alone and in Combination With Azoles Against Exophiala dermatitidis
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  88. System Level Mechanisms of Adaptation, Learning, Memory Formation and Evolvability: The Role of Chaperone and Other Networks
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  89. Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats
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  90. HSP90 inhibitors decrease AID levels and activity in mice and in human cells
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  91. Multiple functionalities of molecular chaperones revealed through systematic mapping of their interaction networks
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  92. Establishing Order Through Disorder by the Hsp90 Molecular Chaperone
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  93. Hsp90 interaction networks in fungi—tools and techniques
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  94. Diagnostic value of HSP90α and related markers in lung cancer
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  95. Drought priming evokes essential regulation of Hsp gene families, Hsfs and their related miRNAs and induces heat stress tolerance in chickpea
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  96. Enrichment and aggregation of topological motifs are independent organizational principles of integrated interaction networks
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  97. Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States
    Stephanie Diezmann, Michelle D. Leach, Leah E. Cowen · 2015 · PLoS ONE
  98. Exploring Mechanisms of Allosteric Regulation and Communication Switching in the Multiprotein Regulatory Complexes of the Hsp90 Chaperone with Cochaperones and Client Proteins: Atomistic Insights from Integrative Biophysical Modeling and Network Analysis of Conformational Landscapes
    Gennady M. Verkhivker · 2022 · Journal of Molecular Biology
  99. The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells
    Jianjun Zhang, Zhichao Zheng, Yan Zhao, Tao Zhang, Xiaohu Gu, Wei Yang · 2012 · Clinical and Experimental Medicine
  100. Molecular Evolutionary Mechanisms Driving Functional Diversification of the HSP90A Family of Heat Shock Proteins in Eukaryotes
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