Cited by 328Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

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H3K27 Demethylases, at Long Last

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Swigut, Tomek, Wysocka, Joanna·2007·Cell

DOI 10.1016/j.cell.2007.09.026

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Abstract

Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
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Self-citation
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
De Santa, F., Totaro, M. G., Prosperini, E., Notarbartolo, S., Testa, G., & Natoli, G. (2007) · Cell · doi:10.1016/j.cell.2007.08.019 · Cited by 965
Regulation of histone methylation by demethylimination and demethylation
Klose, R. J., & Zhang, Y. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2143 · Cited by 922

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Agger, 2007, Nature
De Santa, 2007, Cell
Lan, 2007, Nature
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Authors: Swigut, T., & Wysocka, J.
Affiliations: Stanford Medicine (US)
Corresponding author: Wysocka, Joanna
ORCID: Swigut, Tomek
Wysocka, Joanna
Venue: Cell
Publisher: Elsevier BV
Published: 2007-10
Volume: 131
Issue: 1
Pages: 29-32
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2007.09.026
OpenAlex: W1971180847
Cited by: 327
References: 18
Citations by year: 2026: 7 · 2025: 10 · 2024: 15 · 2023: 11 · 2022: 19 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 12 · 2016: 17 · 2015: 20 · 2014: 19 · 2013: 18 · 2012: 26
FWCI: 8.21
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: H3K27 demethylase, H3K27 methylation, polycomb repressive complex 2, JmjC domain proteins, KDM6A, JMJD3, histone demethylation, gene silencing, gene activation, body patterning, inflammation
MeSH terms: Animals, Gene Expression Regulation, Immune System, Methylation, Oxidoreductases, N-Demethylating, Repressor Proteins, Homeodomain Proteins, Body Patterning, Gene Silencing, Epigenesis, Genetic, Jumonji Domain-Containing Histone Demethylases, Polycomb-Group Proteins

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H3K27 Demethylases, at Long Last

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