The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
H3K27 Demethylases, at Long Last
Open accessAbstract
Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.
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In the citing paper
“KDM6A/B mediate the removal of the suppressive chromatin modification H3K27me3, which is associated with silenced genes26.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [26]
In the citing paper
“Enrichment of mRNAs encoding the H3K27me3-specific demethylases, KDM6A/B26 in cbMg (Supplementary Fig. 5b, Supplementary Table 3) as well as the up-regulation of Kdm6a/b in microglia upon exposure to dying cells in vitro (Fig. 3c, Supplementary Fig. 10g) point to the possible role of PRC2/H3K27me3 in suppressing clearance-promoting genes in stMg.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [26]
In the citing paper
“Among the genes that become rapidly induced in microglia upon exposure to apoptotic cells were the cbMg-enriched Kdm6a/b, which encode histone demethylases26 (Fig. 3c, Supplementary Fig. 10g).”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [26]
Citations
Cites
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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Agger, K., Cloos, P. A., Christensen, J. F., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E., & Helin, K. (2007) · Nature · doi:10.1038/nature06145 · Cited by 1,392
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Self-citationDe Santa, F., Totaro, M. G., Prosperini, E., Notarbartolo, S., Testa, G., & Natoli, G. (2007) · Cell · doi:10.1016/j.cell.2007.08.019 · Cited by 965
Regulation of histone methylation by demethylimination and demethylation
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Flagged first, then by citations
Research works printed but not linked: 4
- Agger, 2007, Nature
- De Santa, 2007, Cell
- Lan, 2007, Nature
- Lee, 2007, Science
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Sorted by citations
Items 301–328 of 328
Differential Regulation of Large-scale Chromosome Conformations in Osteoblasts and OsteosarcomaPreprint
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Differential regulation of mesoscale chromosome conformations in osteoblasts and osteosarcoma
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Investigation of histone lysine methylation in stem cell differentiation using inhibitor peptide
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The molecular mechanism of the aberrant expression of the B-cell specific PAX5 gene in t(8;21) AML
Ray, D. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Swigut, T., & Wysocka, J.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Wysocka, Joanna
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 131
- Issue
- 1
- Pages
- 29-32
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1971180847
- Cited by
- 327
- References
- 18
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 11 · 2022: 19 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 12 · 2016: 17 · 2015: 20 · 2014: 19 · 2013: 18 · 2012: 26
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- H3K27 demethylase, H3K27 methylation, polycomb repressive complex 2, JmjC domain proteins, KDM6A, JMJD3, histone demethylation, gene silencing, gene activation, body patterning, inflammation
- MeSH terms
- Animals, Gene Expression Regulation, Immune System, Methylation, Oxidoreductases, N-Demethylating, Repressor Proteins, Homeodomain Proteins, Body Patterning, Gene Silencing, Epigenesis, Genetic, Jumonji Domain-Containing Histone Demethylases, Polycomb-Group Proteins
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