The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles
Open accessAbstract
Satellite cells reside beneath the basal lamina of skeletal muscle fibers and include cells that act as precursors for muscle growth and repair. Although they share a common anatomical localization and typically are considered a homogeneous population, satellite cells actually exhibit substantial heterogeneity. We used cell-surface marker expression to purify from the satellite cell pool a distinct population of skeletal muscle precursors (SMPs) that function as muscle stem cells. When engrafted into muscle of dystrophin-deficient mdx mice, purified SMPs contributed to up to 94% of myofibers, restoring dystrophin expression and significantly improving muscle histology and contractile function. Transplanted SMPs also entered the satellite cell compartment, renewing the endogenous stem cell pool and participating in subsequent rounds of injury repair. Together, these studies indicate the presence in adult skeletal muscle of prospectively isolatable muscle-forming stem cells and directly demonstrate the efficacy of myogenic stem cell transplant for treating muscle degenerative disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Skeletal muscle repair is facilitated by a population of dedicated muscle stem cells (MuSCs), also known as satellite cells, that reside in anatomically defined niches within muscle tissues.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [6]
In the citing paper
“Subsequently, MuSCs undergo multiple rounds of self-renewing divisions that are essential to their function in regeneration, as demonstrated by transplantation, genetic ablation, and lineage tracing experiments5–12.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [6]
In the citing paper
“Several groups have reported successful replenishment of the stem cell pool by satellite cell transplantation into dystrophic or irradiated/injured muscles in mice120,139,140, although the rarity of satellite cells in muscle tissue has been a challenge for translating muscle stem cell transplantation to clinical practice141”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [139]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Self-citationMyogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,646
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449
Collins, C. A., Olsen, I., Zammit, P. S., Heslop, L., Petrie, A., Partridge, T. A., & Morgan, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.05.010 · Cited by 1,445
The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation
Sicinski, P., Geng, Y., Ryder-Cook, A. S., Barnard, E. A., Darlison, M. G., & Barnard, P. J. (1989) · Science · doi:10.1126/science.2662404 · Cited by 1,276
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
Montarras, D., Morgan, J., Collins, C., Relaix, F., Zaffran, S., Cumano, A., Partridge, T., & Buckingham, M. (2005) · Science · doi:10.1126/science.1114758 · Cited by 1,100
Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application
Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., & Weissman, I. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141007 · Cited by 1,025
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–472 of 472
Molecular Mechanisms of Muscle Stem Cell Aging
Baig, A. H., & Tümpel, S. (2012) · Else Kröner-Fresenius Symposia · doi:10.1159/000338030
Stem Cells for the Treatment of Muscular Dystrophy
Tedesco, F. S., Sampaolesi, M., & Cossu, G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-385942-6.00056-1
Retention of Stem Cell Properties Post-expansion in Myosphere Culture
Yan, W., Kaufmann, A. M., & Albers, A. E. (2012) · Stem cells and cancer stem cells · doi:10.1007/978-94-007-4798-2_3
Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells
Gayraud-Morel, B., Chrétien, F. C., Jory, A., Sambasivan, R., Négroni, E., Flamant, P., Soubigou, G., Coppée, J., Santo, J. P. D., Cumano, A., et al. (2012) · Development · doi:10.1242/dev.084186
potentials for adult skeletal muscle stem cells.
Gayraud-Morel, B., Sambasivan, R., Négroni, E., Flamant, P., & Soubigou, G. (2013)
Stem Cell Diversity and Applications in Therapy
Oliveira, K., Guia, M., Bezerra, J. M., & Azevedo, C. F. (2016) · International Blood Research & Reviews · doi:10.9734/ibrr/2016/23258
Stearns-Reider, K. M., & Ambrosio, F. (2015) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-4939-3228-3_8
Stem cells and regenerative medicine
Fernandes, T. G., Diogo, M. M., & Cabral, J. M. S. (2013) · Elsevier eBooks · doi:10.1533/9781908818300.177
Chen, J., & Li, Q. (2016) · InTech eBooks · doi:10.5772/62819
Therapeutic Approach of iPS Cell Technology for Treating Muscular Dystrophy
Sakurai, H. (2016) · Springer eBooks · doi:10.1007/978-4-431-55678-7_9
Regulation of Satellite Cell Homeostasis by C/EBPβ: Therapeutic Perspectives
Lala-Tabbert, N. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-457
Stem Cell Therapies to Treat Muscular Dystrophy to Date
Meregalli, M., Farini, A., Parolini, D., Maciotta, S., & Torrente, Y. (2010)
The Cellular and Molecular Axis of Muscle Regeneration
Ieronimakis, N. M. (2014) · ResearchWorks at the University of Washington (University of Washington)
Review Article Applications of skeletal muscle progenitor cells for neuromuscular diseases
Hosoyama, T., Dyke, J. V., & Suzuki, M. (2012)
Embryonic and Adult Stem Cells Explored through Microfluidics and Biological Manipulation
Jabart, E. (2013) · eScholarship (California Digital Library)
Muscle Stem Cell Biology and Implications in Gene Therapy
Partridge, T. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-03095-7_4
Balakrishnan, K. R. (2014) · eScholarship (California Digital Library)
Abreu, P., & Kowaltowski, A. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/845438
A Multi-angled Approach to Discover and Improve Skeletal Muscle Stem Cell Therapies
Davoudi, S. (2019) · TSpace (University of Toronto)
Cosgrove, B. D., & Blau, H. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-381422-7.10020-3
Stem Cells in Dystrophic Animal Models: From Preclinical to Clinical Studies
Sitzia, C., Erratico, S., Farini, A., Torrente, Y., & Meregalli, M. (2014) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-03572-7_1
Mesenchymal stem cells in skeletal muscle regeneration
de la Garza-Rodea, A. S. (2011)
Cerletti, M., Rao, T. N., Cole, D. A., Moore, J. T., Chuang, T. T., Becherer, D. J., Sheckler, L. R., Stimpson, S. A., Schroeder, J. J., Inlay, M. A., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3244794
Self-citationMSC Therapy in Animal Models and in Regenerative Medicine for Human Diseases
Zipori, D. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-130-1_8
Role of Lamina-associated polypeptide 2 alpha in striated muscle differentiation and regeneration
Gotić, I. (2009) · University of Vienna · doi:10.25365/thesis.7771
Tracking Dynamics of Muscle Engraftment in Small Animals by In Vivo Fluorescent Imaging
Yang, Z., Zeng, Q., Ma, Z., Wang, Y., & Xu, X. (2009) · Journal of Visualized Experiments · doi:10.3791/1388-v
van Buul, G. M., & van Osch, G. J. V. M. (2013) · Springer eBooks · doi:10.1007/978-94-007-5690-8_17
A preview of selected articles
Atkinson, S. P. (2021) · Stem Cells · doi:10.1002/stem.3350
VÁZIZOMSÉRÜLÉS KEZELÉSEK JELENLEGI MÓDJAINAK ÁTTEKINTÉSE
Gyenes, D., Budai, Z., & Sarang, Z. (2020) · STADIUM - Hungarian Journal of Sport Sciences · doi:10.36439/sjsc.v3i1.5423
Rossi, F. M. V., & Paylor, B. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717748073.793153358
(2008) · Nature Genetics · doi:10.1038/ng0808-937
Parise, G. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734161666.793552121
VÁZIZOMSÉRÜLÉS KEZELÉSEK JELENLEGI MÓDJAINAK ÁTTEKINTÉSE
Gyenes, D., Budai, Z., & Sarang, Z. (2020) · STADIUM - Hungarian Journal of Sport Sciences · doi:10.36439/hjsc/2020/1/5423
(2008) · Nature Biotechnology · doi:10.1038/nbt0808-888
Rawlins, E. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.2384956.793463448
Vnencak‐Jones, C. L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6164-9.00040-8
Takenaka-Ninagawa, N., & Sakurai, H. (2022) · リハビリテーション医学 : 日本リハビリテーション医学会誌 · doi:10.2490/jjrmc.59.1020
Tavakoli, S., Adatto, I., Kakhki, S. A., Chan, V., Fotowat, H., Gähwiler, E. K. N., Manning, M. E., Messemer, K. A., Rangan, A., Yang, S. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.13.523942
Self-citationZhang, H., Li, Z., Cheng, Q.-S., Chen, X., Zhang, C., & Zeng, T. (2023) · Transplant Immunology · doi:10.1016/j.trim.2023.101796
Clinical Trials of Cell Therapy and Regenerative Medicine in Muscular Dystrophies
Skuk, D. (2023) · Springer eBooks · doi:10.1007/978-981-99-0846-2_17-1
Stem cell therapeutic approaches and signaling pathways in rheumatoid arthritis and osteoarthritis
Ahmed, N. A., Yassin, N. Y. S., Zaky, M. Y., & Ahmed, O. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18800-8.00016-2
Cells–biomaterials structure–function at different length scales
Mishra, S., & Kumarasamy, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91821-3.00020-7
Introduction on Stem Cell Therapy and Regeneration
Masrour, M., Moeinafshar, A., & Rezaei, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00059-7
Then and Now: Regenerative Medicine --- A Short Over view
(2022) · Archives of Health Science · doi:10.31829/2641-7456/ahs2022-6(1)-009
Porpiglia, E., & Blau, H. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-822213-3.00003-6
Clinical Trials of Cell Therapy and Regenerative Medicine in Muscular Dystrophies
Skuk, D. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_17
Exercise-Induced Myostimulin Enhances Muscle Function in Health and DiseasePreprint
Hillger, F., Hansjörg, K., Furrer, A., Melly, S., Julian, B., Seddik, S., Pierrel, E., Fiona, B., Scharenberg, M., Xavier, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.09.647960
Khosrowpour, Z., Ramaswamy, N., Engquist, E. N., Dincer, B., Shah, A. M., Soliman, H. A. N., Goloviznina, N. A., Karachunski, P. I., & Kyba, M. (2025) · Cells · doi:10.3390/cells14151150
Physiological and mechanical influences on muscle function following total knee arthroplasty
Hamilton, D. F. (2011) · ERA
Buchanan, S. M., Price, F. D., Castiglioni, A., Gee, A. W., Schneider, J., Matyas, M. N., Hayhurst, M., Tabebordbar, M., Wagers, A. J., & Rubin, L. L. (2020) · Figshare · doi:10.6084/m9.figshare.13076700
Self-citationJeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943075
Buchanan, S. M., Price, F. D., Castiglioni, A., Gee, A. W., Schneider, J., Matyas, M. N., Hayhurst, M., Tabebordbar, M., Wagers, A. J., & Rubin, L. L. (2020) · Figshare · doi:10.6084/m9.figshare.13076709
Self-citationJeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943078
Jeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943066
Buchanan, S. M., Price, F. D., Castiglioni, A., Gee, A. W., Schneider, J., Matyas, M. N., Hayhurst, M., Tabebordbar, M., Wagers, A. J., & Rubin, L. L. (2020) · Figshare · doi:10.6084/m9.figshare.13076703
Self-citationJeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943072
Buchanan, S. M., Price, F. D., Castiglioni, A., Gee, A. W., Schneider, J., Matyas, M. N., Hayhurst, M., Tabebordbar, M., Wagers, A. J., & Rubin, L. L. (2020) · Figshare · doi:10.6084/m9.figshare.13076712
Self-citationBuchanan, S. M., Price, F. D., Castiglioni, A., Gee, A. W., Schneider, J., Matyas, M. N., Hayhurst, M., Tabebordbar, M., Wagers, A. J., & Rubin, L. L. (2020) · Figshare · doi:10.6084/m9.figshare.13076706
Self-citationJeon, S. G., Lee, J., Lee, S. J., Seo, J., Choi, J., Bae, D. H., Chun, D.-H., Ko, S. Y., Shin, H. S., Joo, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26943069
Beyond muscle weakness: pathogenesis of sepsis-induced myopathy and its management
Liu, Y., Zhao, X., Xu, Z., Liu, Q., & Wang, Y.-C. (2026) · Open Medicine · doi:10.1515/med-2025-1342
Role of CTGF and TNF on fibrosis in muscular dystrophy
Steger, J. G. C. (2014) · theses.fr (ABES) · doi:10.70675/0e5cabb6zabbbz47bfza555z5a0e014f1c39
L1 retrotransposon activity in muscle cells
Lopez, P. P. (2020) · theses.fr (ABES) · doi:10.70675/d6a87136z1044z4451z9156z5fd79eb81aff
Chapotte-Baldacci, C.-A. (2021) · theses.fr (ABES) · doi:10.70675/7b99cb30z1d3fz483bz9d63z379d67023e35
Biomaterials for Skeletal Muscle Stem Cell Transplantation and Expansion
Park, G., & Han, W. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30151-3.00008-5
Peacker, B. L., Lin, K., Lam, A., Rios, C. L., Zhu, K., Goldstein, J., Messemer, K. A., Ellis, R., Florea, M., Kletzien, H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.30.735705
Self-citationJaklin, F. J., Keller, L., Spittler, A., Reissig, L., & Aszmann, O. C. (2026) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2026.153348
Engelbrecht, L. (2013) · SUNScholar (Stellenbosch University)
The role of human blood-vessel-derived stem cells in tissue repair and regeneration
Chen, C.-W. W. (2012) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Cerletti, M., Jurga, S., Witczak, C. A., Hirshman, M. F., Shadrach, J. L., Goodyear, L. J., & Wagers, A. J.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- Wagers, Amy J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 134
- Issue
- 1
- Pages
- 37-47
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3665268
- OpenAlex
- W2019428638
- Cited by
- 472
- References
- 49
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 16 · 2023: 14 · 2022: 9 · 2021: 24 · 2020: 31 · 2019: 23 · 2018: 19 · 2017: 18 · 2016: 29 · 2015: 29 · 2014: 33 · 2013: 39 · 2012: 46
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK068626)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (F32AR051663)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- skeletal muscle stem cells, satellite cells, dystrophic muscle, mdx mice, dystrophin deficiency, cell transplantation, muscle regeneration, stem cell heterogeneity, stem cell engraftment
- MeSH terms
- Animals, Cell Separation, Humans, Membrane Proteins, Mice, Inbred C57BL, Muscle Contraction, Muscular Dystrophy, Animal, Dystrophin, Muscle, Skeletal, Satellite Cells, Skeletal Muscle, Stem Cell Transplantation, Mice, Adult Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
