Hirshman, Michael F.

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated Receptors

Cited by 5,652

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,180

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science

Muscle Physiology and DisordersTelomeres, Telomerase, and Senescence

Cited by 824

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

Musi, N., Hirshman, M. F., Nygren, J., Svanfeldt, M., Bavenholm, P., Rooyackers, O., Zhou, G., Williamson, J. M., Ljunqvist, O., Efendic, S., et al. (2002) · Diabetes

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 806

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 774

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 743

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles

Cerletti, M., Jurga, S., Witczak, C. A., Hirshman, M. F., Shadrach, J. L., Goodyear, L. J., & Wagers, A. J. (2008) · Cell

Muscle Physiology and DisordersNeurogenetic and Muscular Disorders Research

Cited by 472

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

Hayashi, T., Hirshman, M. F., Fujii, N., Habinowski, S. A., Witters, L. A., & Goodyear, L. J. (2000) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 447

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Norris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., et al. (2003) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 417

Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes

Kennedy, J. W., Hirshman, M. F., Gervino, E. V., Ocel, J. V., Forse, R. A., Hoenig, S. J., Aronson, D., Goodyear, L. J., & Horton, E. S. (1999) · Diabetes

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 415

AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise

Musi, N., Fujii, N., Hirshman, M. F., Ekberg, I., Fröberg, S., Ljungqvist, O., Thorell, A., & Goodyear, L. J. (2001) · Diabetes

Metabolism, Diabetes, and CancerNatural Antidiabetic Agents Studies

Cited by 371

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle

Fujii, N., Hayashi, T., Hirshman, M. F., Smith, J. T., Habinowski, S. A., Kaijser, L., Mu, J., Ljungqvist, O., Birnbaum, M. J., Witters, L. A., et al. (2000) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 351

Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise

Devlin, J. T., Hirshman, M., Horton, E. D., & Horton, E. S. (1987) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 342

Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, K., Hirshman, M. F., & Goodyear, L. J. (2006) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 315

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, K., Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C., & Kahn, C. R. (2002) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 207

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism

Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 204

Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3

Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 202

AMP-activated Protein Kinase α2 Activity Is Not Essential for Contraction- and Hyperosmolarity-induced Glucose Transport in Skeletal Muscle

Fujii, N., Hirshman, M. F., Kane, E. M., Ho, R. C., Peter, L. E., Seifert, M. M., & Goodyear, L. J. (2005) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 177

Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis

O’Neill, B. T., Lauritzen, H. P. M. M., Hirshman, M. F., Smyth, G., Goodyear, L. J., & Kahn, C. R. (2015) · Cell Reports

Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth Factors

Cited by 171

Skeletal muscle plasma membrane glucose transport and glucose transporters after exercise

Goodyear, L. J., Hirshman, M. F., King, P. A., Horton, E. D., Thompson, C. M., & Horton, E. S. (1990) · Journal of Applied Physiology

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 160

Exercise and regulation of carbohydrate metabolism

Mul, J. D., Stanford, K. I., Hirshman, M. F., & Goodyear, L. J. (2015) · Progress in molecular biology and translational science

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 151

Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring

Stanford, K. I., Lee, M.-Y., Getchell, K. M., So, K., Hirshman, M. F., & Goodyear, L. J. (2015) · Diabetes

Birth, Development, and HealthGestational Diabetes Research and Management

Cited by 151

TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

An, D., Toyoda, T., Taylor, E. B., Yu, H., Fujii, N., Hirshman, M. F., & Goodyear, L. J. (2010) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 147

Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway

Higaki, Y., Mikami, T., Fujii, N., Hirshman, M. F., Koyama, K., Seino, T., Tanaka, K., & Goodyear, L. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism

Redox biology and oxidative stressMetabolism, Diabetes, and Cancer

Cited by 138