The DOI matches its Crossref record; 74 of the 76 references it cites were found in a registry or an index.
Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity
Open accessAbstract
Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity. We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing. Conversely, conditional removal of Otx2 from non-PV cells or from the visual pathway abolished plasticity. Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“On the other hand, an experience-dependent accumulation of exogenous OTX2, a homeoprotein commonly bound to PNNs and PV1 cells in the mPFC (Lee et al., 2017), is necessary for the formation of PNNs and critical period closure in the visual cortex (Sugiyama et al., 2008).”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Sugiyama et al., 2008
In the citing paper
“For example, reductions of inhibitory neural activity in adulthood have increased visual plasticity in rodents (He et al., 2007, Sugiyama et al., 2008, Harauzov et al., 2010) and even restored visual function in amblyopic adult rats (Vetencourt et al., 2008).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Accordingly, disruption of E-I balance powerfully shifts the timing and quality of critical period development, as seen in the primary visual cortex (V1) (27–29).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [27]
In the citing paper
“Second, PNN disruption prevents the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells required for their maintenance (27, 40, 41) (Fig. S3).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [27]
In the citing paper
“Compromised PNNs prevent the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells needed for their maturation (including PNN maintenance itself) (27, 40, 41).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [27]
In the citing paper
“Blocking Otx2 transport in the retina (between bipolar cells and retinal ganglion cells) or in the cortex (by directly infusing anti-Otx2 antibodies) retards the activity-dependent opening of CP in the visual cortex (Sugiyama et al., 2008).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“In support of the hypothesis is that direct infusion of Otx2 before CP opening opens CP ahead of time and also closes it ahead of time (Sugiyama et al., 2008).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Moreover, the opening of plasticity (first threshold) does not take place in dark-reared animals, where the Otx2 and PV levels remain low in PV-cells.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Accordingly, we showed that Otx2 injected in the eye can travel along this pathway and terminates in PV-cells (Sugiyama et al., 2008; Sugiyama et al., 2009).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Subsequent Otx2 internalization increases intracellular Otx2 and PV-cell maturation reflected by further PV expression and PNN assembly (Sugiyama et al., 2008) until a second threshold is reached that closes plasticity.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Instead, PV-cell maturation in dark-reared animals is rescued by direct Otx2 infusion leading to its specific accumulation in PV-cells and CP opening (Sugiyama et al., 2008).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Otx2 expression coincides with both PV and PNN expression in the cortex during critical period plasticity (Sugiyama et al., 2008).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Sugiyama et al., 2008
In the citing paper
“PNNs also regulate PV cell maturation via internalization of homeoprotein Otx2, which is needed for transcription, normal PV development and critical period plasticity in developing visual cortex (Sugiyama et al. 2008).”
From Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice (2018) · cites this paper as Sugiyama et al. 2008
In the citing paper
“this homeoprotein signals the maturation of the parvalbumin-containing GABAergic interneurons, which contributes to the opening and possibly also the closure of the critical period”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Sugiyama et al., 2008
In the citing paper
“PNNs also facilitate the capture and uptake of the transcription factor Otx2, which in turn promotes PVBC maturation as well as further PNN development (100, 173, 912, 1063).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1063]
In the citing paper
“PNNs also facilitate the capture and uptake of the transcription factor Otx2, which in turn promotes PVBC maturation as well as further PNN development (100, 173, 912, 1063).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1063]
In the citing paper
“The maturation of cortical inhibitory networks in the postnatal brain is important for initiating this critical period (Fagiolini and Hensch, 2000; Sugiyama et al., 2008).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Acceleration of PV-cell maturation by over-expressing non-cell-autonomous factors, such as brain-derived neurotrophic factor (BDNF) or orthodenticle homeobox 2 (Otx2), induces precocious plasticity (Huang et al., 1999; Sugiyama et al., 2008).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Sugiyama et al., 2008
In the citing paper
“PNNs have been linked to the transcription factor orthodenticle homeobox protein 2 (OTX2) (35)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [35]
In the citing paper
“Additionally, OTX2 has been shown to specifically accumulate in PV+ cells through exogenous transfer from the choroid plexus, the region where it is produced (35; 46).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [35]
In the citing paper
“Orthodenticle homeobox protein 2 (OTX2) is a transcription factor known to be important in the regulation of the critical period of plasticity in the visual cortex of developing mice (46) and its expression coincides with the maturation of PV+ cells and the closure of the critical period (35).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [35]
Citations
Cites
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE
Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.1003 · Cited by 2,628
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Self-citationReactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198
The origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · cited 1×
“Cortical interneurons originate within the subcortical telencephalon (for PV-cells the medial ganglionic eminence) and then migrate tangentially into the overlying cortex but never express Otx2 (Butt et al., 2007; Wonders and Anderson, 2006).”
BackgroundLocal GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910
Self-citationExperience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse
Gordon, J. A., & Stryker, M. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03274.1996 · Cited by 856
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781
Inhibitory threshold for critical-period activation in primary visual cortex
Fagiolini, M., & Hensch, T. K. (2000) · Nature · doi:10.1038/35004582 · Cited by 716
Self-citation
Flagged first, then by citations
2 of the 76 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 401–491 of 491
Astrocyte regulation of critical period plasticity across neural circuits
Brandt, J. P., & Ackerman, S. D. (2024) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2024.102948 · Cited by 2
“Ocular dominance plasticity is well-conserved in other mammals, including mice, which exhibit peak plasticity at postnatal day 28 and limited plasticity by 3 months of age [2,15,42].”
Obesity induced transcriptional changes in skeletal muscle across different species
Wang, Y., Zhang, J., Yang, X., Wang, F., Jin, L. G., Li, J., Li, X., & Li, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0327988 · Cited by 2
Schwartz, B. A., Wang, W.-H., & Bao, S.-W. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.056 · Cited by 1
Neuroproteomics applied to the study of visual cortex plasticity
Rossi, F., & Pizzorusso, T. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.04.021 · Cited by 2
The Nuclear Transitory Zone: A Key Player in the Cerebellar Development
Ghiyamihoor, F., Rad, A. A., & Marzban, H. (2025) · The Cerebellum · doi:10.1007/s12311-025-01848-5 · Cited by 2
“…the migration of Cajal–Retzius cells [ 123] and oligodendrocyte precursors [124 ], EN1/2 modulates retinal ganglion cell axon guidance [ 125–127], and OTX2 signaling governs the timing of critical period plasticity in the visual, auditory, and medial prefrontal cortices [128], reviewed in [87].”
Xu, J., Hörner, M., Nagel, M., Perhat, P., Korneck, M., Noß, M., Hauser, S., Schöls, L. J., Admard, J., Casadei, N., et al. (2025) · Open Biology · doi:10.1098/rsob.250101 · Cited by 1
Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex
Qin, Y., Wang, W., Gu, Y., & Shi, X. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01448-7 · Cited by 2
“PNNs are wrapped around PV neurons and promote the aggregation of Otx2 [99] and Sema 3A [35]; IGF-1 [103] and Crtl1 [98] can enhance the expression of PNNs. PSD-95 promotes excitatory synapse maturation and dendritic spine stability [107, 108].”
Single-Cell Visualization Deep in Brain Structures by Gene Transfer
Sugiyama, S., Sugi, J., Iijima, T., & Hou, X. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.586043 · Cited by 2
Self-citationDistinct roles of homeoproteins in brain topographic mapping and in neural circuit formation
Stettler, O., & Moya, K. L. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.07.004 · Cited by 2
Otx genes and seizure susceptibility
(2014) · Molecular & Cellular Epilepsy · doi:10.14800/mce.74 · Cited by 2
“Indeed, Otx2 secreted from subcortical structures (retina, dorsal lateral geniculate nucleus and choroid plexus) accumulates in visual cortical PV cells, regulating their maturation [36-38] .”
BackgroundIntermittent divergent squint in prematurity and its neurophysiological aspects
Sharma, K., Panwar, P., & Chaudhary, K. (2017) · Journal of Pediatric Neurosciences · doi:10.4103/jpn.jpn_11_17 · Cited by 2
Hypotheses concerning how Otx2 makes its incredible journey: a hitchhiker on the road to Rome?
Edelstein, L. R., & Smythies, J. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00055 · Cited by 2
“When injected into the eye Otx2 is transported to the visual cortex where it enters PV-expressing GABAergic INs (PVs), which it activates (Sugiyama et al., 2008; Beurdeley et al., 2012; Carlier et al., 2013; Spatazza et al., 2013a,b).”
BackgroundMethodInfluentialXu, J.-S., Hörner, M., Nagel, M., Perhat, P., Korneck, M., Noß, M., Hauser, S., Schöls, L., Admard, J., Casadei, N., et al. (2024) · bioRxiv · doi:10.1101/2024.03.26.586780 · Cited by 1
“…they can influence gene transcription and be involved in plasticity, axon pathfinding and neuroprotection (Sgado et al. , 2006; Cox et al. , 2008; Sugiyama et al. , 2008; Wizenmann et al. , 2009; Torero Ibad et al. , 2011; Ben-Yaakov et al. , 2012; Ji & Jaffrey, 2012; Kadkhodaei et al. , 2013).”
BackgroundHsiao, Y., Fonseca, M. A., Tiemroth, A. S., Vasquez, E. J., & Gomez, A. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.16.633439 · Cited by 2
Chen, Y., Jiang, C., Yan, B., & Zhang, J. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.70007 · Cited by 1
“PV neurons are known to regulate the onset of critical periods and plasticity of the visual cortex (Hensch 2005; Sugiyama et al. 2008).”
Jacobs-Brichford, E., Donka, R. M., Lasek, A. W., Hsu, T. M., & Roitman, J. D. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.03.039 · Cited by 1
“The pattern of PNN and PV+ cell emergence in PFC observed here is consistent with experience-dependent critical period development of PNNs in other cortical regions (Bernard & Prochiantz, 2016; Dityatev et al., 2007; Sugiyama et al., 2008).”
Wang, L., & Maffei, A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6978-1_1 · Cited by 1
“expected to be lost by postnatal days 13 (P13) until very recently, when Hensch and collaborators found non-cell-autonomous Otx2 coordinates the maturation of PV-expressing interneurons even after the third postnatal week and that visual experience promotes the accumulation of Otx2 in PV-cells ( Sugiyama et al. 2008 ).”
BackgroundInsights into Visual Cortex Plasticity: Interaction Between Genes and Sensory Experience
Fernando, J. B., & Caleo, M. (2012) · InTech eBooks · doi:10.5772/50721 · Cited by 1
Inhibition of Cdk5 in PV Neurons Reactivates Experience-Dependent Plasticity in Adult Visual Cortex
Zhang, X., Tang, H., Li, S., Liu, Y., Wu, W., Li, Y., Ma, C., Ma, X., Chen, L., & Yang, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010186 · Cited by 1
Bamsey, J. L., Brunt, L. H., & Scholpp, S. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.12.005 · Cited by 1
do Amaral, F. L., Rodrigues, T. A., da Silva, N. L. T., Diniz, I. N. A., de Morais, L. N. A., Diniz, D. G., Brites, D. M. T. O., Anthony, D. C., & Diniz, C. W. P. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70179
“The transcription factor Otx2, secreted by the choroid plexus and internalized by the PV+ interneurons, has been shown to control the timing of PNN formation and the onset of plasticity (Beurdeley et al. 2012; Sakai and Sugiyama 2018; Sugiyama et al. 2008).”
How to navigate counter dogmatic research findings
Prochiantz, A. (2018) · The EMBO Journal · doi:10.15252/embj.201898945 · Cited by 1
“However, when it works, it can be extremely successful and put your hypothesis in the forefront (Brunet et al , 2005; Sugiyama et al , 2008; Wizenmann et al , 2009).”
Self-citationMikami, T., & Kitagawa, H. (2021) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2004.1e · Cited by 1
Studies on Semaphorin 3A in the Neuromuscular
Heutink, P. D. P., Hol, D. E., Pasterkamp, D. R. J., Fonds, V. L., Bv, L., Tri, C., Vo, T., Bossers, B. D. K., & Vo, T. T. (2011) · Data Archiving and Networked Services (DANS) · Cited by 1
Cummings, J. A. (2016) · doi:10.14418/wes01.1.1210 · Cited by 1
“Furthermore, delivering the protein into one hemisphere of the visual cortex in animals raised in darkness significantly increases the number of PV-expressing neurons and perineuronal nets in comparison to the non-treated hemisphere (Sugiyama et al. 2008).”
The Role of Perineuronal Nets in Regulating Barrel Cortex Physiology
Chu, P. (2015) · CUNY Academic Works (City University of New York) · Cited by 1
Otx2 stimulates adult retinal ganglion cell regenerationPreprint
Ibad, R. T., Quenech’Du, N., Prochiantz, A., & Moya, K. L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.06.327999 · Cited by 1
Self-citationIdentification of a new, Rab14-dependent, endo-lysosomal pathwayPreprint
Trofimenko, E., Homma, Y., Fukuda, M., & Widmann, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.25.436964 · Cited by 1
Editorial: Brain extracellular matrix: Involvement in adult neural functions and disease volume II
Pantazopoulos, H., & Berretta, S. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.1009456 · Cited by 1
“PNNs ensheath distinct populations of neurons and regulate key neural functions such as synaptic plasticity, electrophysiological properties and access to neuroactive molecules (Kalb and Hockfield, 1988; Sugiyama et al., 2008; Gogolla et al., 2009).”
BackgroundScarlatti, F. (2023) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/gfuet · Cited by 2
Gibel-Russo, R., & Nardo, A. A. D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.04.578782 · Cited by 1
“OTX2 activity promotes PV expression and critical period onset and also participates in critical period closure through induction of PNN expression (Beurdeley et al., 2012; Sugiyama et al., 2008).”
BackgroundGlycan Structure and Neural Plasticity
Mikami, T., & Kitagawa, H. (2014) · Springer eBooks · doi:10.1007/978-4-431-55381-6_7
Brunette, K. E. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Developmental function of PirB restricts adult ocular dominance plasticity
Mann, M. (2009) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.10606
Zenonos, G. A., & Kim, J. E. (2010) · Neurosurgery · doi:10.1227/01.neu.0000375280.14650.3a
Life without glutamate: the epigenetic effects of glutamate deletion
Edelstein, L. R., Fuxé, K., & Smythies, J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00014
“THE ROLE OF OTX2 It is possible that another part of the mechanism responsible may be a homeoprotein such as Otx2 that is carried from the thalamus to the cortex, via the glutamatergic input (Sugiyama et al., 2008; Beurdeley et al., 2012; Carlier et al., 2013; Spatazza et al., 2013).”
BackgroundWittrup, A. (2009) · Lund University Publications (Lund University)
Critical period plasticity and sensory function in a neuroligin-3 model of autism
LeBlanc, J. J. (2013) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Synaptic Specificity and Plasticity in Parvalbumin-Basket Cell Circuits
Bogart, L. J. (2015) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Greifzu, F. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4372
Araujo, O. A. D., & Folha, C. (2013)
Chondroitin Sulfate Proteoglycans Regulate Experience-Dependent Neuronal Plasticity
Miyata, S., & Kitagawa, H. (2011) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.23.239
Mécanismes du transfert intercellulaire des homéoprotéines
Lin, T. (2015) · theses.fr (ABES) · doi:10.70675/02fc235czd35fz44f9z9324z1ce16ebbf4d3
“, 2009), aswell as for other homeoproteins in neuronal plasticity (Sugiyama et al., 2008; Beurdeley et al., 2012; Spatazza et al., 2013b), eye field development (Lesaffre et al.”
BackgroundKalogeraki, E. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6103
Genetic determination and layout rules of visual cortical architecture
Liedtke, J. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6458
Stodieck, S. K. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6478
Axon-seq decodes the motor axon transcriptome and its modulation in response to ALSPreprint
Nijssen, J., Benitez, J. A., Hoogstraaten, R. I., Kee, N., & Hedlund, E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/321596
Competition and boundary formation in heterogeneous media: Application to neuronal differentiationPreprint
Benoît Perthame, B., Quiñinao, C., & Touboul, J. D. (2014) · arXiv (Cornell University) · doi:10.48550/arxiv.1408.2091
“where they exert they transcriptional activity. This direct signaling was experimentally demonstrated in vivo during development in the zebrafish [21, 34], or involved in plasticity of adult networks [6, 29, 28, 7]. The spatial extension and rate of this process are very low: transcription factors can diffuse and reach…”
BackgroundNon-cell autonomous OTX2 transcription factor regulates anxiety-related behaviors in the mousePreprint
Vincent, C., Gilabert‐Juan, J., Alvarez‐Fischer, D., Nardo, A. A. D., Krebs, M., Pen, G. L., & Prochiantz, A. (2019) · HAL
Self-citationNakamura, T., Kurosaki, K., Kanemoto, M., Sasahara, M., & Ichijo, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.23.056200
“Maturation of circuits reduces plasticity and closes the critical period through the development of inhibitory PV neurons (Sugiyama et al., 2008; Miyata et al., 2012).”
BackgroundMcgillis, K. (2018) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Studies on retina-specific gene expression
Reinisalo, M. (2012) · UEF eRepo (University of Eastern Finland)
Odenwald, N. (2019) · TSpace (University of Toronto)
Elucidating Memory Specificity by Exploring Parvalbumin Interneuron Modulation of Perineuronal Nets
Yeung, B.-R. A. (2020) · TSpace (University of Toronto)
PERINEURONAL NETS IN HIPPOCAMPAL AREA CA2: REGULATION BY ACTIVITY AND DISEASE
Carstens, K. E. (2018) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/khgn-dw13
Cortical Processing of Frequency Modulated Sweeps in a Mouse Model of Presbycusis
Trujillo, M. S. (2012) · eScholarship (California Digital Library)
Mikami, T., & Kitagawa, H. (2021) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2004.1j
Prochiantz, A. (2010) · L’annuaire du Collège de France · doi:10.4000/annuaire-cdf.309
Self-citation(2018) · Elsevier eBooks · doi:10.1016/b978-1-78548-295-3.50015-7
Mechanisms of Experience-dependent Prevention of Plasticity in Visual Circuits
Balmer, T. S. (2022) · Digital Archive @ GSU · doi:10.57709/5814205
Warren, I. D., & Knowles, A. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0792-23.2023
Experience-dependent plasticity of cortical inhibition
van Versendaal, D. (2024) · doi:10.5463/thesis.609
Colodete, D. A. E. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2023.tde-06022024-101938
Self-Reported Findings of the Korean Intermittent Exotropia Multicenter Study Questionnaire
Yang, H. K., Park, S. H., Lee, H., Kim, S.-Y., Gye, H. J., Kim, S. Y., Shin, S. Y., & Lim, K. H. (2024) · Korean Journal of Ophthalmology · doi:10.3341/kjo.2023.0129
“Several factors have been postulated as the neurodevelopmental mechanisms of intermittent exotropia in prematurity [25,26].”
BackgroundOf travelling homeoproteins and medulloblastomas
Vigneul, E., Krins, F., & Clotman, F. (2025) · Oncogene · doi:10.1038/s41388-025-03523-9
“…representations of the known non-cell autonomous roles of OTX2, including in vitro [10] and in vivo [11, 12] experiment, as well as transcriptional [11] and non-transcriptional [12] post-transfer targets. and in postmitotic, migrating granule cells, while its expression is lost as post migratory…”
InfluentialMicroglia: Key Players in Perineuronal Net Dynamics
Garmendia-Berges, M., & Puerta, E. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1012413 · Cited by 1
Sánchez-Moreno, B., Mesa-Lombardo, A., de la Fuente‐Fernández, M., Fraga-Sanchez, A. I., Calzado-González, Á., García-Ortiz, I., Martínez-Jiménez, M., García‐Piqueras, J., Vega‐Avelaira, D., Claudio Toma, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.04.692295
Experience-dependent plasticity of layer 2/3 circuits in developing somatosensory neocortex
Wen, J. A. (2018) · KiltHub Repository · doi:10.1184/r1/6716537
Functional Organization and Plasticity of Visual Cortex over the Lifespan of the Ferret
Whitney, D. E. (2013) · KiltHub Repository · doi:10.1184/r1/6717416
Visual experience drives functional reorganization of cortical GABAergic circuitsPreprint
Sun, S., Yue, Y., Li, Z., Perrenoud, Q., & Cardin, J. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.12.705412
Quiñinao, C. (2015) · doi:10.70675/bfb0756bza6e2z4fd9zb5bfze7453a4e0f71
“An important novelty of this study is to introduce in the calculations the intercellular transfer of HPs allowed by two short peptidic sequences present in their DNA-binding domain [138, 80, 143, 163, 139, 92, 114, 168].”
Synaptic changes upon removal of extracellular perineuronal nets in adult mouse visual cortex
Faini, G. (2017) · theses.fr (ABES) · doi:10.70675/7b38d504z7edfz47dezbf9az0a8668ae448a
“In mice, cortical infusion of recombinant Otx2 protein before CP onset accelerates CP timing, while the extracellular blocking of Otx2 protein delays CP onset (Sugiyama et al., 2008).”
BackgroundDevienne, G. F. (2019) · theses.fr (ABES) · doi:10.70675/453418efzc908z49e0zba6fz71fefaa50691
“Indeed, Otx2 accumulation in PV interneurons is activity-dependent, Otx2 induces changes in the transcriptional program of these neurons, and the block of Otx2 import induces PNN regression in the adult (Sugiyama et al. 2008, Beurdeley et al. 2012, Apulei et al. 2018).”
InfluentialFelgerolle, C. (2019) · theses.fr (ABES) · doi:10.70675/fbd5cf69zed5az4a57zbfdez48e26a937a72
Etude du rôle du Syndécan à la jonction neuromusculaire de Caenorhabditis elegans
Vachon, C. (2020) · theses.fr (ABES) · doi:10.70675/4f34af1dzeed7z426dzbab2zb1e21a201491
Douceau, S. (2020) · theses.fr (ABES) · doi:10.70675/6f1007f2z8468z4365zb07dz7d863bf32cd5
Regulation of homeoproteins intercellular transfer
Amblard, I. (2020) · theses.fr (ABES) · doi:10.70675/bbf68b66zb816z4669z84f4zec67820f5b54
Altérations de la connectivité corticale au cours de périodes critiques du développement
Druart, M. (2020) · theses.fr (ABES) · doi:10.70675/b4f48d73za850z42b2z8dadzfad47d4f0a69
Rôle des astrocytes dans la période critique de la plasticité visuelle
Breton, R. (2023) · theses.fr (ABES) · doi:10.70675/9140a00az6c88z4fb6zaabfz9eb16e7593ca
Rodrigues, K. S., Yamashita, R., & Katada, S. (2026) · Frontiers in Neural Circuits · doi:10.3389/fncir.2026.1818927
“Notably, PV interneurons do not express Otx2 themselves (Sugiyama et al., 2008).”
Panday, M., Monteiro, L., Daudi, A., & Murphy, K. M. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1848222
Cramer, T. L. M., Hannan, S. B., Petre, L., Bear, M. F., Hensch, T. K., & Tyagarajan, S. K. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03672-7
Self-citationThe Critical Period Microbiota Shape Brain PlasticityPreprint
Damiani, F., Ashtiani, K. C., Tognozzi, A., Abdelkarim, S., Cornuti, S., Caldarelli, M., Baldi, P., & Tognini, P. (2026) · Research Square · doi:10.64898/2026.06.08.730811
Smith, J. J., Taylor, S. R., Destain, H., Kim, G., Hall, D. H., White, J. G., Miller, D. M., & Kratsios, P. (2026) · Nature Communications · doi:10.1038/s41467-026-76320-x
Barr, C. L., Wigg, K. G., Feng, Y., Blokland, K., Wilkinson, M., Kerr, E. N., Guger, S., Lovett, M. W., Strug, L. J., Oefner, R., et al. (2026) · Genes Brain & Behavior · doi:10.1111/gbb.70071
“At the molecular level, the expression of OTX2 is responsible for the maturation of parvalbumin-positive inhibitory neurons that control plasticity onset [93].”
Interneurons and network activity in the cerebral cortex: a developmental dialogue
Moissidis, M., & Marín, Ó. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01088-4
Metadata
- Authors
- Sugiyama, S., Di Nardo, A. A., Aizawa, S., Matsuo, I., Volovitch, M., Prochiantz, A., & Hensch, T. K.
- Affiliations
- Boston Children's Hospital (US)
- RIKEN (JP)
- Osaka Women's and Children's Hospital (JP)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Prochiantz, Alain
- Hensch, Takao K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 134
- Issue
- 3
- Pages
- 508-520
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2150947848
- Cited by
- 491
- References
- 76
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 22 · 2023: 23 · 2022: 16 · 2021: 32 · 2020: 33 · 2019: 25 · 2018: 26 · 2017: 31 · 2016: 20 · 2015: 38 · 2014: 42 · 2013: 41 · 2012: 28
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Otx2, homeoproteins, parvalbumin interneurons, visual cortex, critical period, ocular dominance, visual experience, GABAergic circuits, neural circuit development
- MeSH terms
- Animals, Humans, Interneurons, Neuronal Plasticity, Parvalbumins, Recombinant Proteins, Sensory Deprivation, Visual Cortex, Visual Pathways, Mice, Otx Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
