Otx2-PNN interaction to regulate cortical plasticity
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The ability of the environment to shape cortical function is at its highest during critical periods of postnatal development. In the visual cortex, critical period onset is triggered by the maturation of parvalbumin inhibitory interneurons, which gradually become surrounded by a specialized glycosaminoglycan-rich extracellular matrix: the perineuronal nets. Among the identified factors regulating cortical plasticity in the visual cortex, extracortical homeoprotein Otx2 is transferred specifically into parvalbumin interneurons and this transfer regulates both the onset and the closure of the critical period of plasticity for binocular vision. Here, we review the interaction between the complex sugars of the perineuronal nets and homeoprotein Otx2 and how this interaction regulates cortical plasticity during critical period and in adulthood.
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Otx-2 maintains PNNs.
“Otx--2, which maintains PNNs (Beurdeley et al., 2012;Bernard and Prochiantz, 2016)”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Bernard and Prochiantz, 2016
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Synaptic changes upon removal of extracellular perineuronal nets in adult mouse visual cortex
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- Authors
- Bernard, C., & Prochiantz, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Prochiantz, Alain
- Venue
- Neural Plasticity
- Publisher
- Hindawi Limited
- Published
- 2016
- Volume
- 2016
- Pages
- 1-7
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC4736602
- OpenAlex
- W1562783671
- Cited by
- 102
- References
- 80
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale pour la Recherche (ANR-10-BLAN-141-01, 339379)
- ERC Advanced Grant HOMEOSIGN (ANR-10-BLAN-141-01, 339379)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- Otx2, perineuronal nets, cortical plasticity, critical period, visual cortex, parvalbumin interneurons, extracellular matrix, glycosaminoglycans, homeoproteins, binocular vision, postnatal development, interneuron maturation
- MeSH terms
- Animals, Critical Period, Psychological, Extracellular Matrix, Humans, Interneurons, Neuronal Plasticity, Parvalbumins, Visual Cortex, Extracellular Matrix Proteins, Otx Transcription Factors
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