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Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity
Open accessAbstract
Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity. We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. Visual experience promoted the accumulation of non-cell-autonomous Otx2 in PV-cells, and cortical infusion of exogenous Otx2 accelerated both PV-cell development and critical period timing. Conversely, conditional removal of Otx2 from non-PV cells or from the visual pathway abolished plasticity. Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit.
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In the citing paper
“On the other hand, an experience-dependent accumulation of exogenous OTX2, a homeoprotein commonly bound to PNNs and PV1 cells in the mPFC (Lee et al., 2017), is necessary for the formation of PNNs and critical period closure in the visual cortex (Sugiyama et al., 2008).”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Sugiyama et al., 2008
In the citing paper
“For example, reductions of inhibitory neural activity in adulthood have increased visual plasticity in rodents (He et al., 2007, Sugiyama et al., 2008, Harauzov et al., 2010) and even restored visual function in amblyopic adult rats (Vetencourt et al., 2008).”
From The impact of developmental timing for stress and recovery (2015) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Accordingly, disruption of E-I balance powerfully shifts the timing and quality of critical period development, as seen in the primary visual cortex (V1) (27–29).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [27]
In the citing paper
“Second, PNN disruption prevents the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells required for their maintenance (27, 40, 41) (Fig. S3).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [27]
In the citing paper
“Compromised PNNs prevent the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells needed for their maturation (including PNN maintenance itself) (27, 40, 41).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [27]
In the citing paper
“Blocking Otx2 transport in the retina (between bipolar cells and retinal ganglion cells) or in the cortex (by directly infusing anti-Otx2 antibodies) retards the activity-dependent opening of CP in the visual cortex (Sugiyama et al., 2008).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“In support of the hypothesis is that direct infusion of Otx2 before CP opening opens CP ahead of time and also closes it ahead of time (Sugiyama et al., 2008).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Moreover, the opening of plasticity (first threshold) does not take place in dark-reared animals, where the Otx2 and PV levels remain low in PV-cells.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Accordingly, we showed that Otx2 injected in the eye can travel along this pathway and terminates in PV-cells (Sugiyama et al., 2008; Sugiyama et al., 2009).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Subsequent Otx2 internalization increases intracellular Otx2 and PV-cell maturation reflected by further PV expression and PNN assembly (Sugiyama et al., 2008) until a second threshold is reached that closes plasticity.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Instead, PV-cell maturation in dark-reared animals is rescued by direct Otx2 infusion leading to its specific accumulation in PV-cells and CP opening (Sugiyama et al., 2008).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Otx2 expression coincides with both PV and PNN expression in the cortex during critical period plasticity (Sugiyama et al., 2008).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Sugiyama et al., 2008
In the citing paper
“PNNs also regulate PV cell maturation via internalization of homeoprotein Otx2, which is needed for transcription, normal PV development and critical period plasticity in developing visual cortex (Sugiyama et al. 2008).”
From Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice (2018) · cites this paper as Sugiyama et al. 2008
In the citing paper
“this homeoprotein signals the maturation of the parvalbumin-containing GABAergic interneurons, which contributes to the opening and possibly also the closure of the critical period”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Sugiyama et al., 2008
In the citing paper
“PNNs also facilitate the capture and uptake of the transcription factor Otx2, which in turn promotes PVBC maturation as well as further PNN development (100, 173, 912, 1063).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1063]
In the citing paper
“PNNs also facilitate the capture and uptake of the transcription factor Otx2, which in turn promotes PVBC maturation as well as further PNN development (100, 173, 912, 1063).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1063]
In the citing paper
“The maturation of cortical inhibitory networks in the postnatal brain is important for initiating this critical period (Fagiolini and Hensch, 2000; Sugiyama et al., 2008).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Sugiyama et al., 2008
In the citing paper
“Acceleration of PV-cell maturation by over-expressing non-cell-autonomous factors, such as brain-derived neurotrophic factor (BDNF) or orthodenticle homeobox 2 (Otx2), induces precocious plasticity (Huang et al., 1999; Sugiyama et al., 2008).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Sugiyama et al., 2008
In the citing paper
“PNNs have been linked to the transcription factor orthodenticle homeobox protein 2 (OTX2) (35)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [35]
In the citing paper
“Additionally, OTX2 has been shown to specifically accumulate in PV+ cells through exogenous transfer from the choroid plexus, the region where it is produced (35; 46).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [35]
In the citing paper
“Orthodenticle homeobox protein 2 (OTX2) is a transcription factor known to be important in the regulation of the critical period of plasticity in the visual cortex of developing mice (46) and its expression coincides with the maturation of PV+ cells and the closure of the critical period (35).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [35]
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Perineuronal nets in brain physiology and disease
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Self-citationExtracellular Movement of Signaling Molecules
Müller, P., & Schier, A. F. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.001 · Cited by 145
“…(Gregor et al., 2007), some homeodomain transcription factors that move through cell membranes (Prochiantz and Joliot, 2003; Brunet et al., 2007; Sugiyama et al., 2008; Wizenmann et al., 2009), and signals that move through special cellular channels such as gap junctions in animals (Esinduy et…”
BackgroundChondroitin sulfates and their binding molecules in the central nervous system
Djerbal, L., Lortat-Jacob, H., & Kwok, J. (2017) · Glycoconjugate Journal · doi:10.1007/s10719-017-9761-z · Cited by 144
“During this period, Otx2 is transferred from choroid plexus into the visual cortex and accumulates on the PNN of PVcells [164].”
BackgroundLensjø, K. K., Christensen, A. C., Tennøe, S., Fyhn, M., & Hafting, T. (2017) · eneuro · doi:10.1523/eneuro.0379-16.2017 · Cited by 133
Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
Mangin, J., Li, P., Scafidi, J., & Gallo, V. (2012) · Nature Neuroscience · doi:10.1038/nn.3190 · Cited by 139
Vo, T., Carulli, D., Ehlert, E., Kwok, J. C. F., Dick, G., Mecollari, V., Moloney, E. B., Neufeld, G., de Winter, F., Fawcett, J. W., et al. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.04.009 · Cited by 150
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134
Kim, S. Y., Senatorov, V. V., Morrissey, C. S., Lippmann, K., Vazquez, O. N., Milikovsky, D. Z., Gu, F., Parada, I., Prince, D. A., Becker, A. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07394-3 · Cited by 141
Oohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131
The transcription factor Otx2 regulates choroid plexus development and function
Johansson, P. A., Irmler, M., Acampora, D., Beckers, J., Simeone, A., & Götz, M. (2013) · Development · doi:10.1242/dev.090860 · Cited by 130
“Notably, the Otx2 protein itself is also secreted (Sugiyama et al., 2008) and might hence be present in different amounts in the CSF from Gdf7-Cre/Otx2fl/fl embryos compared with control embryos.”
BackgroundDirect Detection of Biotinylated Proteins by Mass Spectrometry
Schiapparelli, L., McClatchy, D. B., Liu, H.-H., Sharma, P., Yates, J. R., & Cline, H. T. (2014) · Journal of Proteome Research · doi:10.1021/pr5002862 · Cited by 127
Progressive maturation of silent synapses governs the duration of a critical period
Huang, X., Stodieck, S. K., Goetze, B., Cui, L., Wong, M. H., Wenzel, C., Hosang, L., Dong, Y., Löwel, S., & Schlüter, O. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506488112 · Cited by 136
Carceller, H., Guirado, R., Ripolles-Campos, E., Teruel-Marti, V., & Nacher, J. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0291-20.2020 · Cited by 112
An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity
Carulli, D., & Verhaagen, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052434 · Cited by 136
“Neural activity drives the release of developmental regulators, which promote PV neuron maturation, including brain-derived neurotrophic factor (BDNF) [14], neuronal pentraxins (NARP) [15], neuregulins [16], and orthodenticle homeobox 2 (Otx2) [17].”
InfluentialImpact of Early Life Stress on Reward Circuit Function and Regulation
Hanson, J. L., Williams, A. V., Bangasser, D. A., & Peña, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.744690 · Cited by 133
Murthy, S., Kane, G. A., Katchur, N. J., Lara Mejia, P. S., Obiofuma, G., Buschman, T. J., McEwen, B. S., & Gould, E. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.021 · Cited by 118
Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity
Sun, Y., Ikrar, T., Davis, M. F., Gong, N., Zheng, X., Luo, Z. D., Lai, C., Mei, L., Holmes, T. C., Gandhi, S. P., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.033 · Cited by 117
“Previous studies have identified that signaling through neurotrophins (nerve growth factor and brain-derived neurotrophic factor), insulin-like growth factor-1, transcriptional control by OTX2, maturation of the extracellular matrix, and synapse formation molecules contribute to regulation of visual cortical plasticit…”
BackgroundExtracellular Engrailed Participates in the Topographic Guidance of Retinal Axons In Vivo
Wizenmann, A., Brunet, I., Lam, J. S. Y., Sonnier, L., Beurdeley, M., Zarbalis, K. S., Weisenhorn, D. M. V., Weinl, C., Dwivedy, A., Joliot, A., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.018 · Cited by 117
Self-citationGABAergic inhibition in visual cortical plasticity
Sale, A. (2010) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2010.00010 · Cited by 122
“Sugiyama et al. (2008) have demonstrated that another factor might impinge on IGI development to promote CP onset.”
Nowicka, D., Soulsby, S., Skangiel‐Kramska, J., & Glazewski, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06996.x · Cited by 110
“…Neuroscience, 30, 2053–2063 et al., 1990; Hensch et al., 1998; Huang et al., 1999; Pizzorusso et al., 2002; Iwai et al., 2003; Jiao et al., 2006; Majewska & Sur, 2006; Dityatev et al., 2007; McRae et al., 2007; Bahia et al., 2008; Bartley et al., 2008; Sugiyama et al., 2008; Nakamura et al., 2009).”
BackgroundObligatory Role for the Immediate Early Gene NARP in Critical Period Plasticity
Gu, Y., Huang, S., Chang, M., Worley, P. F., Kirkwood, A., & Quinlan, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.016 · Cited by 124
“For example, promotion of the early maturation of inhibitory synapses onto principle neurons induces a precocious initiation of the critical period (Huang et al., 1999; Di Cristo et al., 2007; Sugiyama et al., 2008).”
BackgroundNatural Restoration of Critical Period Plasticity in the Juvenile and Adult Primary Auditory Cortex
Zhou, X., Panizzutti, R., de Villers‐Sidani, E., Madeira, C., & Merzenich, M. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6470-10.2011 · Cited by 121
“Recent studies also argue that the embryonic Otx2 homeoprotein controls changes in parvalbumin GABAA neurons that may open and close the critical period in the visual cortex (Sugiyama et al., 2008).”
BackgroundNetwork homeostasis: a matter of coordination
Maffei, A., & Fontanini, A. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.012 · Cited by 116
Fuentealba, P., Klausberger, T., Karayannis, T., Suen, W. Y., Huck, J., Tomioka, R., Rockland, K., Capogna, M., Studer, M., Morales, M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4199-09.2010 · Cited by 113
“The diversity of GABAergic cells is generated at early embryonic stages in the ventral telencephalon (Flames and Marín, 2005; Wonders and Anderson, 2006), and their functional maturation requires cell type-specific transcription factors (Sugiyama et al., 2008).”
BackgroundClock Genes Control Cortical Critical Period Timing
Kobayashi, Y., Ye, Z., & Hensch, T. K. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.036 · Cited by 99
Self-citationFunctions of Chondroitin Sulfate and Heparan Sulfate in the Developing Brain
Maeda, N., Ishii, M., Nishimura, K., & Kamimura, K. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0324-y · Cited by 111
Age-dependent effect of hearing loss on cortical inhibitory synapse function
Takesian, A. E., Kotak, V. C., & Sanes, D. H. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00515.2011 · Cited by 107
Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS
Nijssen, J., Benitez, J. A., Hoogstraaten, R. I., Kee, N., & Hedlund, E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.11.005 · Cited by 104
“Some TFs were recently shown to function outside the soma and to be important in neuronal circuitry plasticity, axon pathfinding, and neuroprotection (Sugiyama et al., 2008; Torero Ibad et al., 2011; Wizenmann et al., 2009).”
BackgroundPerineuronal nets affect parvalbumin expression in GABA ergic neurons of the mouse hippocampus
Yamada, J., Ohgomori, T., & Jinno, S. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12792 · Cited by 99
“Maturation of the PV+ neuron network that controls plasticity onset is regulated by selective re-expression of embryonic orthodenticle homeobox 2 (Otx2) in the visual cortex (Sugiyama et al., 2008).”
BackgroundInfluentialOtx2-PNN interaction to regulate cortical plasticity
Bernard, C., & Prochiantz, A. (2016) · Neural Plasticity · doi:10.1155/2016/7931693 · Cited by 102
“Interestingly, Otx2 conditional knockdown heterozygous mice have a delayed onset of ocular dominance critical period, suggesting that a 50% reduction in Otx2 protein is sufficient to alter PV-cell maturation [32].”
BackgroundInfluentialSelf-citationSommeijer, J.-P., & Levelt, C. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035323 · Cited by 100
“Especially the maturation of synapses formed by parvalbumin (PV) positive interneurons seems to determine the start of the sensitive period [3].”
BackgroundPatrizi, A., Picard, N., Simon, A. J., Gunner, G., Centofante, E., Andrews, N. A., & Fagiolini, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.018 · Cited by 100
Miller, G. M., & Hsieh‐Wilson, L. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.015 · Cited by 101
Davis, M. F., Figueroa Velez, D. X., Guevarra, R. P., Yang, M. C., Habeeb, M., Carathedathu, M. C., & Gandhi, S. P. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.062 · Cited by 97
“Several manipulations of inhibition have been shown to stimulate plasticity in mouse visual cortex up to postnatal day 70 (P70) (Beurdeley et al., 2012; Fagiolini and Hensch, 2000; Kuhlman et al., 2013; Southwell et al., 2010; Stephany et al., 2014; Sugiyama et al., 2008).”
Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
Nahmani, M., & Turrigiano, G. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.029 · Cited by 97
“…level of GABAergic inhibition (Hensch et al., 1998; Iwai et al., 2003; Fagiolini et al., 2004), likely originating from the maturation of FS interneuron connections (Huang et al., 1999; Pizzorusso et al., 2002; Chattopadhyaya et al., 2004; Maffei et al., 2006, 2010; Sugiyama et al., 2008).”
InfluentialProlonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
Morishita, H., Cabungcal, J.-H., Chen, Y., Do, K. Q., & Hensch, T. K. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.026 · Cited by 92
Self-citationPerineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95
Origins of strabismus and loss of binocular vision
Quoc, E. B., & Milleret, C. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00071 · Cited by 93
Komitova, M., Xenos, D., Salmaso, N., May Tran, K., Brand, T., Schwartz, M. L., Ment, L., & Vaccarino, F. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5286-12.2013 · Cited by 88
Baker, K., Gray, A. R., & Richardson, R. (2017) · Behavioral Neuroscience · doi:10.1037/bne0000203 · Cited by 100
Bozzelli, P. L., Alaiyed, S., Kim, E., Villapol, S., & Conant, K. E. (2018) · Neural Plasticity · doi:10.1155/2018/5735789 · Cited by 93
“Expression of PNN components by PV neurons in particular is intriguing in a way that it may be regulated in significant part by the homeobox protein orthodenticle homeobox-2 (Otx2) [32].”
BackgroundGABA through the Ages: Regulation of Cortical Function and Plasticity by Inhibitory Interneurons
Lehmann, K., Steinecke, A., & Bolz, J. (2012) · Neural Plasticity · doi:10.1155/2012/892784 · Cited by 94
Murase, S., Lantz, C. L., & Quinlan, E. M. (2017) · eLife · doi:10.7554/elife.27345 · Cited by 87
“…barrier to structural plasticity, the regu- lation of neuronal excitability via the accumulation of cations and other effectors (Härtig et al., 1999; Sugiyama et al., 2008), the protection of neurons from oxidative stress (Cabungcal et al., 2013) and the sequestration of molecules that inhibit…”
Larsen, B., Sydnor, V. J., Keller, A. S., Yeo, B. T. T., & Satterthwaite, T. D. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.007 · Cited by 93
Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons
Tang, Y., Stryker, M. P., Álvarez-Buylla, A., & Espinosa, J. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421844112 · Cited by 88
Nabel, E. M., & Morishita, H. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00146 · Cited by 85
The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J. (2016) · Neural Plasticity · doi:10.1155/2016/3679545 · Cited by 84
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
Spijker, H. M. V. ‘., & Kwok, J. C. F. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00033 · Cited by 89
“When Otx2 reaches the visual cortex, it binds the PNNs and enters the neuron to regulate maturation and thus affect plasticity (Sugiyama et al., 2008).”
BackgroundTranscriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing
Han, X., Wu, X., Chung, W.-Y., Li, T., Nekrutenko, A., Altman, N. S., Chen, G., & Ma, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902417106 · Cited by 83
Social Origins of Developmental Risk for Mental and Physical Illness
Cameron, J. L., Eagleson, K. L., Fox, N. A., Hensch, T. K., & Levitt, P. R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1822-17.2017 · Cited by 89
“Factors that may accelerate or delay GABA circuit maturation, such as BDNF (Huang et al., 1999; Bath et al., 2013), Clock gene expression (Kobayashi et al., 2015; Marco et al., 2016), Otx2 (Sugiyama et al., 2008; Pena et al., 2017), or the GUCY1A3 mentioned above (Sabatini et al., 2007), may be vulnerable to ELS, pred…”
BackgroundSelf-citationGenetic Otx2 mis-localization delays critical period plasticity across brain regions
Lee, H. H. C., Bernard, C., Ye, Z., Acampora, D., Simeone, A., Prochiantz, A., Di Nardo, A. A., & Hensch, T. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.1 · Cited by 82
Self-citation
Metadata
- Authors
- Sugiyama, S., Di Nardo, A. A., Aizawa, S., Matsuo, I., Volovitch, M., Prochiantz, A., & Hensch, T. K.
- Affiliations
- Boston Children's Hospital (US)
- RIKEN (JP)
- Osaka Women's and Children's Hospital (JP)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Prochiantz, Alain
- Hensch, Takao K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 134
- Issue
- 3
- Pages
- 508-520
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2150947848
- Cited by
- 491
- References
- 76
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 22 · 2023: 23 · 2022: 16 · 2021: 32 · 2020: 33 · 2019: 25 · 2018: 26 · 2017: 31 · 2016: 20 · 2015: 38 · 2014: 42 · 2013: 41 · 2012: 28
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1847 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Otx2, homeoproteins, parvalbumin interneurons, visual cortex, critical period, ocular dominance, visual experience, GABAergic circuits, neural circuit development
- MeSH terms
- Animals, Humans, Interneurons, Neuronal Plasticity, Parvalbumins, Recombinant Proteins, Sensory Deprivation, Visual Cortex, Visual Pathways, Mice, Otx Transcription Factors
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