The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Regulation and Evolution of a Genetic Switch Controlling Sexually Dimorphic Traits in Drosophila
Open accessAbstract
SUMMARY Sexually dimorphic traits play key roles in animal evolution and behavior. Little is known, however, about the mechanisms governing their development and evolution. One recently evolved dimorphic trait is the male-specific abdominal pigmentation of Drosophila melanogaster, which is repressed in females by the Bric-à-brac (Bab) proteins. To understand the regulation and origin of this trait, we have identified and traced the evolution of the genetic switch controlling dimorphic bab expression. We show that the HOX protein Abdominal-B (ABD-B) and the sex-specific isoforms of Doublesex (DSX) directly regulate a bab cis-regulatory element (CRE). In females, ABD-B and DSXF activate bab expression whereas in males DSXM directly represses bab, which allows for pigmentation. A new domain of dimorphic bab expression evolved through multiple fine-scale changes within this CRE, whose ancestral role was to regulate other dimorphic features. These findings reveal how new dimorphic characters can emerge from genetic networks regulating pre-existing dimorphic traits.
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Cites
The genetical theory of natural selection
Fisher, R. A. (1930) · doi:10.5962/bhl.title.27468 · Cited by 17,617
Evolution at Two Levels: On Genes and Form
Carroll, S. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030245 · Cited by 882
Self-citationGene duplication and the adaptive evolution of a classic genetic switch
Hittinger, C. T., & Carroll, S. B. (2007) · Nature · doi:10.1038/nature06151 · Cited by 439
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Cited by
Cis-regulatory elements: Molecular mechanisms and evolutionary processes underlying divergence
Wittkopp, P. J., & Kalay, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3095 · Cited by 1,231
Stepwise Modification of a Modular Enhancer Underlies Adaptation in a Drosophila Population
Rebeiz, M., Pool, J. E., Kassner, V. A., Aquadro, C. F., & Carroll, S. B. (2009) · Science · doi:10.1126/science.1178357 · Cited by 249
Self-citationSex and the Single Cell. II. There Is a Time and Place for Sex
Robinett, C. C., Vaughan, A. G., Knapp, J.-M., & Baker, B. S. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000365 · Cited by 242
Kazemian, M., Suryamohan, K., Chen, J.-Y., Zhang, Y., Samee, M. A. H., Halfon, M. S., & Sinha, S. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu184 · Cited by 42
Metadata
- Authors
- Williams, T. M., Selegue, J. E., Werner, T., Gompel, N., Kopp, A., & Carroll, S. B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 134
- Issue
- 4
- Pages
- 610-623
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2136348345
- Cited by
- 307
- References
- 3
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Williams, T. M., Selegue, J. E., Werner, T., Gompel, N., Kopp, A., & Carroll, S. B. (2008). The Regulation and Evolution of a Genetic Switch Controlling Sexually Dimorphic Traits in Drosophila. Cell. https://doi.org/10.1016/j.cell.2008.06.052
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