Cited by 458Fungal and yeast genetics researchEvolution and Genetic DynamicsChromosomal and Genetic Variations

Gene duplication and the adaptive evolution of a classic genetic switch

Hittinger, Chris Todd, Carroll, Sean B.·2007·Nature

Abstract

How gene duplication and divergence contribute to genetic novelty and adaptation has been of intense interest, but experimental evidence has been limited. The genetic switch controlling the yeast galactose use pathway includes two paralogous genes in Saccharomyces cerevisiae that encode a co-inducer (GAL3) and a galactokinase (GAL1). These paralogues arose from a single bifunctional ancestral gene as is still present in Kluyveromyces lactis. To determine which evolutionary processes shaped the evolution of the two paralogues, here we assess the effects of precise replacement of coding and non-coding sequences on organismal fitness. We suggest that duplication of the ancestral bifunctional gene allowed for the resolution of an adaptive conflict between the transcriptional regulation of the two gene functions. After duplication, previously disfavoured binding site configurations evolved that divided the regulation of the ancestral gene into two specialized genes, one of which ultimately became one of the most tightly regulated genes in the genome.

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Crossref · 10.1038/nature06151

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  • Microbial metabolic networks often provide appropriate functions at a minimal size, and their complexity seems to be correlated with environmental factors.

    “Microbial metabolic networks often provide appropriate functions at a minimal size [134] and furthermore, their complexity seems to be correlated with environmental factors [135].”

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Authors
Hittinger, C. T., & Carroll, S. B.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Carroll, Sean B.
Venue
Nature
Published
2007-10
Volume
449
Issue
7163
Pages
677-681
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1996490834
Cited by
439
References
51
Citations by year
2026: 7 · 2025: 14 · 2024: 26 · 2023: 24 · 2022: 21 · 2021: 23 · 2020: 17 · 2019: 22 · 2018: 17 · 2017: 28 · 2016: 20 · 2015: 30 · 2014: 27 · 2013: 25 · 2012: 27
FWCI
11.51
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
gene duplication, gene divergence, adaptive evolution, genetic novelty, genetic switch, galectin-3, GAL1, paralogs, transcriptional regulation, Saccharomyces cerevisiae, Kluyveromyces lactis, fitness
MeSH terms
Base Sequence, Binding Sites, DNA-Binding Proteins, Galactokinase, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Saccharomyces cerevisiae, Transcription Factors, Gene Expression Regulation, Fungal, Evolution, Molecular, Genes, Duplicate, Gene Duplication, Saccharomyces cerevisiae Proteins

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