The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization
Open accessAbstract
SUMMARY Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein into one of the two daughter cells. Numb is uniformly cortical in interphase but assumes a polarized localization in mitosis. Here, we show that a phosphorylation cascade triggered by the activation of Aurora-A is responsible for the asymmetric localization of Numb in mitosis. Aurora-A phosphorylates Par-6, a regulatory subunit of atypical protein kinase C (aPKC). This activates aPKC, which initially phosphorylates Lethal (2) giant larvae (Lgl), a cytoskeletal protein that binds and inhibits aPKC during interphase. Phosphorylated Lgl is released from aPKC and thereby allows the PDZ domain protein Bazooka to enter the complex. This changes substrate specificity and allows aPKC to phosphorylate Numb and release the protein from one side of the cell cortex. Our data reveal a molecular mechanism for the asymmetric localization of Numb and show how cell polarity can be coupled to cell-cycle progression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanisms of Asymmetric Stem Cell Division
Knoblich, J. A. (2008) · Cell · doi:10.1016/j.cell.2008.02.007 · Cited by 1,015
Self-citationMutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
Glover, D. M., Leibowitz, M. H., McLean, D. A., & Parry, H. (1995) · Cell · doi:10.1016/0092-8674(95)90374-7 · Cited by 836
Rhyu, M. S., Jan, L. Y., & Jan, Y. N. (1994) · Cell · doi:10.1016/0092-8674(94)90112-0 · Cited by 767
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch
Guo, M., Jan, L. Y., & Jan, Y. N. (1996) · Neuron · doi:10.1016/s0896-6273(00)80278-0 · Cited by 670
The Carnegie Protein Trap Library: A Versatile Tool for Drosophila Developmental Studies
Buszczak, M., Paterno, S., Lighthouse, D., Bachman, J., Planck, J., Owen, S., Skora, A. D., Nystul, T. G., Ohlstein, B., Allen, A., et al. (2007) · Genetics · doi:10.1534/genetics.106.065961 · Cited by 577
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
Betschinger, J., Mechtler, K., & Knoblich, J. A. (2003) · Nature · doi:10.1038/nature01486 · Cited by 564
Self-citationBetschinger, J., Mechtler, K., & Knoblich, J. A. (2006) · Cell · doi:10.1016/j.cell.2006.01.038 · Cited by 524
Self-citationMechanisms of asymmetric cell division: flies and worms pave the way
Gönczy, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2388 · Cited by 489
The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila
Bowman, S. K., Rolland, V., Betschinger, J., Kinsey, K. A., Emery, G., & Knoblich, J. A. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.004 · Cited by 444
Self-citation
Cited by
Drosophila neuroblasts: a model for stem cell biology
Homem, C. C. F., & Knoblich, J. A. (2012) · Development · doi:10.1242/dev.080515 · Cited by 476
Self-citationAurora A kinase (AURKA) in normal and pathological cell division
Nikonova, A. S., Astsaturov, I., Serebriiskii, I. G., Dunbrack, R. L., & Golemis, E. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1073-7 · Cited by 448
Asymmetric cell divisions promote Notch-dependent epidermal differentiation
Williams, S. E., Beronja, S., Pasolli, H. A., & Fuchs, E. (2011) · Nature · doi:10.1038/nature09793 · Cited by 406
Zhao, E., Maj, T., Kryczek, I., Li, W., Wu, K., Zhao, L., Wei, S., Crespo, J., Wan, S., Vatan, L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3313 · Cited by 405
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F., & Richardson, H. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.055 · Cited by 346
Metadata
- Authors
- Wirtz-Peitz, F., Nishimura, T., & Knoblich, J. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 135
- Issue
- 1
- Pages
- 161-173
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2152642445
- Cited by
- 369
- References
- 39
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization. https://app.cochat.ai/papers/10.1016/j.cell.2008.07.049
- The paper
- Wirtz-Peitz, F., Nishimura, T., & Knoblich, J. A. (2008). Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization. Cell. https://doi.org/10.1016/j.cell.2008.07.049
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
