The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
Open accessAbstract
SUMMARY Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly due to increasing p16Ink4a expression, but little is known about the mechanisms responsible for these changes. We discovered the Hmga2 transcriptional regulator was highly expressed in fetal neural stem cells but expression declined with age, partly due to increasing let-7b microRNA expression. Hmga2 deficiency reduced stem cell frequency and self-renewal throughout the central and peripheral nervous systems of fetal and young adult mice, but not old adult mice where it was no longer expressed. Hmga2 deficiency did not affect restricted neural progenitor proliferation. Hmga2 deficient fetal and young adult stem cells exhibited increased p16Ink4a and p19Arf expression, and deletion of p16Ink4a and/or p19Arf partially rescued their self-renewal. let-7b over-expression reduced Hmga2 expression and increased p16Ink4a/p19Arf expression. Changes in let-7b and Hmga2 expression during stem cell aging increase p16Ink4a/p19Arf expression and reduce self-renewal.
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Cites
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
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Ink4a/Arf expression is a biomarker of aging
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BackgroundInfluentialIncreasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
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Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
Telley, L., Agirman, G., Prados, J., Amberg, N., Fièvre, S., Oberst, P., Bartolini, G., Vitali, I., Cadilhac, C., Hippenmeyer, S., et al. (2019) · Science · doi:10.1126/science.aav2522 · Cited by 423
Lin28: Primal Regulator of Growth and Metabolism in Stem Cells
Shyh-Chang, N., & Daley, G. Q. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.03.005 · Cited by 458
Suppression of lung adenocarcinoma progression by Nkx2-1
Winslow, M. M., Dayton, T. L., Verhaak, R. G. W., Kim-Kiselak, C., Snyder, E. L., Feldser, D. M., Hubbard, D. D., DuPage, M. J., Whittaker, C. A., Hoersch, S., et al. (2011) · Nature · doi:10.1038/nature09881 · Cited by 467
Metadata
- Authors
- Nishino, J., Kim, I., Chada, K., & Morrison, S. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 135
- Issue
- 2
- Pages
- 227-239
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2106670703
- Cited by
- 627
- References
- 14
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nishino, J., Kim, I., Chada, K., & Morrison, S. J. (2008). Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression. Cell. https://doi.org/10.1016/j.cell.2008.09.017
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