Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310 · see citing works

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989 · see citing works

RAS Is Regulated by the let-7 MicroRNA Family

Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,662 · see citing works

Identification of Tissue-Specific MicroRNAs from Mouse

Lagos‐Quintana, M., Rauhut, R., Yalçın, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 3,298 · see citing works

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint

Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003) · Genes & Development · doi:10.1101/gad.1158803 · Cited by 3,020 · see citing works

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,568 · see citing works

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

Yu, F., Yao, H., Zhu, P., Zhang, X., Pan, Q., Gong, C., Huang, Y., Hu, X., Su, F., Lieberman, J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.054 · Cited by 1,910 · see citing works

Naive and Primed Pluripotent States

Nichols, J., & Smith, A. G. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.015 · Cited by 1,835 · see citing works

Efficient tumour formation by single human melanoma cells

Quintana, E., Shackleton, M. J., Sabel, M. S., Fullen, D. R., Johnson, T. M., & Morrison, S. J. (2008) · Nature · doi:10.1038/nature07567 · Cited by 1,796 · see citing works

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683 · see citing works

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · see citing works

Selective Blockade of MicroRNA Processing by Lin28

Viswanathan, S. R., Daley, G. Q., & Gregory, R. I. (2008) · Science · doi:10.1126/science.1154040 · Cited by 1,442 · see citing works

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403 · see citing works

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374 · see citing works

Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells

Marson, A., Levine, S. S., Cole, M. F., Frampton, G. M., Brambrink, T., Johnstone, S. E., Guenther, M. G., Johnston, W. K., Wernig, M., Newman, J. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.020 · Cited by 1,369 · see citing works

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works

The let-7 family of microRNAs

Roush, S. F., & Slack, F. J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.007 · Cited by 1,332 · see citing works

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,272 · see citing works

The <i>let-7</i> MicroRNA Represses Cell Proliferation Pathways in Human Cells

Johnson, C. D., Esquela-Kerscher, A., Stefani, G., Byrom, M., Kelnar, K., Ovcharenko, D., Wilson, M., Wang, X., Shelton, J., Shingara, J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1083 · Cited by 1,224 · see citing works

The tumor suppressor microRNA let-7 represses the HMGA2 oncogenePreprint

Lee, Y. S., & Dutta, A. (2007) · Genes & Development · doi:10.1101/gad.1540407 · Cited by 1,155 · see citing works

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120 · see citing works

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

Mayr, C., Hemann, M. T., & Bartel, D. P. (2007) · Science · doi:10.1126/science.1137999 · Cited by 1,099 · see citing works

Direct cell reprogramming is a stochastic process amenable to acceleration

Hanna, J. H., Saha, K., Pando, B., van Zon, J. S., Lengner, C. J., Creyghton, M. P., van Oudenaarden, A., & Jaenisch, R. (2009) · Nature · doi:10.1038/nature08592 · Cited by 1,006 · see citing works

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez‐Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Pérez-Terzic, C. M., & Terzic, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.011 · Cited by 980 · see citing works

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

Heo, I., Joo, C., Cho, J., Ha, M., Han, J., & Kim, V. N. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.014 · Cited by 957 · see citing works

The Lin28/let-7 axis regulates glucose metabolism

Zhu, H., Shyh-Chang, N., Segrè, A., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J., Kharas, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.033 · Cited by 907 · see citing works

Extensive post-transcriptional regulation of microRNAs and its implications for cancerPreprint

Thomson, J. M., Newman, M., Parker, J. S., Morin-Kensicki, E. M., Wright, T., & Hammond, S. M. (2006) · Genes & Development · doi:10.1101/gad.1444406 · Cited by 858 · see citing works

The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA

Moss, E. G., Lee, R. C., & Ambros, V. (1997) · Cell · doi:10.1016/s0092-8674(00)81906-6 · Cited by 827 · see citing works

Lin28 promotes transformation and is associated with advanced human malignancies

Viswanathan, S. R., Powers, J. T., Einhorn, W. S., Hoshida, Y., Ng, T., Toffanin, S., O’Sullivan, M. J., Lü, J., Phillips, L. A., Lockhart, V. L., et al. (2009) · Nature Genetics · doi:10.1038/ng.392 · Cited by 816 · see citing works

MicroRNA Let-7a Down-regulates MYC and Reverts MYC-Induced Growth in Burkitt Lymphoma Cells

Sampson, V. B., Rong, N. H., Han, J., Yang, Q., Aris, V. M., Soteropoulos, P., Petrelli, N. J., Dunn, S. P., & Krueger, L. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2462 · Cited by 806 · see citing works

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

Buganim, Y., Faddah, D. A., Cheng, A. W., Itskovich, E., Markoulaki, S., Ganz, K., Klemm, S. L., van Oudenaarden, A., & Jaenisch, R. (2012) · Cell · doi:10.1016/j.cell.2012.08.023 · Cited by 800 · see citing works

Heterochronic Mutants of the Nematode <i>Caenorhabditis elegans</i>

Ambros, V., & Horvitz, H. R. (1984) · Science · doi:10.1126/science.6494891 · Cited by 797 · see citing works

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Rybak‐Wolf, A., Fuchs, H. R., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 788 · see citing works

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

Heo, I., Joo, C., Kim, Y. K., Ha, M., Yoon, M.-J., Cho, J., Yeom, K., Han, J., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2009.08.002 · Cited by 780 · see citing works

Linking functional decline of telomeres, mitochondria and stem cells during ageing

Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759 · see citing works

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

Boiko, A. D., Razorenova, O. V., van de Rijn, M., Swetter, S. M., Johnson, D. L., Ly, D. P., Butler, P. D., Yang, G. P., Joshua, B., Kaplan, M. J., et al. (2010) · Nature · doi:10.1038/nature09161 · Cited by 714 · see citing works

The Increasing Complexity of the Cancer Stem Cell Paradigm

Rosen, J. M., & Jordan, C. T. (2009) · Science · doi:10.1126/science.1171837 · Cited by 699 · see citing works

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells

Melton, C. A., Judson, R. L., & Blelloch, R. H. (2010) · Nature · doi:10.1038/nature08725 · Cited by 693 · see citing works

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

Newman, M. A., Thomson, J. M., & Hammond, S. M. (2008) · RNA · doi:10.1261/rna.1155108 · Cited by 691 · see citing works

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.050 · Cited by 660 · see citing works

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., Kim, J., Zhang, K., & Ding, S. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.11.015 · Cited by 656 · see citing works

MicroRNA-125b is a novel negative regulator of p53Preprint

Le, M. T. N., Teh, C., Shyh‐Chang, N., Xie, H., Zhou, B., Korzh, V. P., Lodish, H. F., & Lim, B. (2009) · Genes & Development · doi:10.1101/gad.1767609 · Cited by 655 · see citing works

Influence of Threonine Metabolism on <i>S</i> -Adenosylmethionine and Histone Methylation

Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., et al. (2013) · Science · doi:10.1126/science.1226603 · Cited by 638 · see citing works

Chromatin-modifying enzymes as modulators of reprogramming

Önder, T. T., Kara, N., Cherry, A. B. C., Sinha, A. U., Zhu, N., Bernt, K. M., Cahan, P., Mancarci, B. O., Unternaehrer, J., Gupta, P. B., et al. (2012) · Nature · doi:10.1038/nature10953 · Cited by 627 · see citing works

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

Nishino, J., Kim, I., Chada, K. K., & Morrison, S. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.017 · Cited by 623 · see citing works

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

Piskounova, E., Polytarchou, C., Thornton, J. E., LaPierre, R. J., Pothoulakis, C., Hagan, J. P., Iliopoulos, D., & Gregory, R. I. (2011) · Cell · doi:10.1016/j.cell.2011.10.039 · Cited by 611 · see citing works

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

Quintana, E., Shackleton, M. J., Foster, H. R., Fullen, D. R., Sabel, M. S., Johnson, T. M., & Morrison, S. J. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.012 · Cited by 599 · see citing works

Stem cell metabolism in tissue development and aging

Shyh‐Chang, N., Daley, G. Q., & Cantley, L. C. (2013) · Development · doi:10.1242/dev.091777 · Cited by 573 · see citing works

Mutations that lead to reiterations in the cell lineages of C. elegans.

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Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.039 · Cited by 512 · see citing works

Metabolic oxidation regulates embryonic stem cell differentiation

Yanes, Ó., Clark, J., Wong, D. M., Patti, G. J., Sánchez‐Ruiz, A., Benton, H. P., Trauger, S. A., Desponts, C., Ding, S., & Siuzdak, G. E. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.364 · Cited by 506 · see citing works

Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis

Tang, F., Bárbácioru, C., Bao, S., Lee, C. G. L., Nordman, E., Wang, X., Lao, K., & Surani, M. A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.015 · Cited by 499 · see citing works

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

Zhang, J., Khvorostov, I., Hong, J. S., Oktay, Y., Vergnes, L., Nuebel, E., Wahjudi, P. N., Setoguchi, K., Wang, G., Do, A., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.401 · Cited by 499 · see citing works

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

Heng, J.-C. D., Feng, B., Han, J., Jiang, J., Kraus, P., Ng, J.-H., Orlov, Y. L., Huss, M., Yang, L., Lufkin, T., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.12.009 · Cited by 486 · see citing works

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

Hagan, J. P., Piskounova, E., & Gregory, R. I. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1676 · Cited by 481 · see citing works

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb

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The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans

Abbott, A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R., & Ambros, V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.009 · Cited by 467 · see citing works

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsPreprint

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Metabolic flux and the regulation of mammalian cell growth

Locasale, J. W., & Cantley, L. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.014 · Cited by 449 · see citing works

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

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MicroRNA Function Is Globally Suppressed in Mouse Oocytes and Early Embryos

Suh, N., Baehner, L., Moltzahn, F., Melton, C. A., Shenoy, A., Chen, J., & Blelloch, R. H. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.044 · Cited by 435 · see citing works

Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans.

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daf-12encodes a nuclear receptor that regulates the dauer diapause and developmental age inC. elegansPreprint

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Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression

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Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

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Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal

Martello, G., Sugimoto, T., Diamanti, E., Joshi, A., Hannah, R., Ohtsuka, S., Göttgens, B., Niwa, H., & Smith, A. G. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.008 · Cited by 389 · see citing works

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues

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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

Molenaar, J. J., Domingo-Fernandéz, R., Ebus, M. E., Lindner, S., Köster, J., Drabek, K., Mestdagh, P., Sluis, P. V., Valentijn, L. J., van Nes, J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2436 · Cited by 382 · see citing works

A role for Lin28 in primordial germ-cell development and germ-cell malignancy

West, J. A., Viswanathan, S. R., Yabuuchi, A., Cunniff, K. C., Takeuchi, A., Park, I., Sero, J., Zhu, H., Pérez‐Atayde, A. R., Frazier, A. L., et al. (2009) · Nature · doi:10.1038/nature08210 · Cited by 371 · see citing works

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

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Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway

Ramachandran, R., Fausett, B. V., & Goldman, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb2115 · Cited by 361 · see citing works

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

Nam, Y., Chen, C., Gregory, R. I., Chou, J. J., & Piotr Sliz, A. (2011) · Cell · doi:10.1016/j.cell.2011.10.020 · Cited by 354 · see citing works

MicroRNA miR-125a controls hematopoietic stem cell number

Guo, S.-Q., Lu, J., Schlanger, R., Zhang, H., Wang, J. Y., Fox, M., Purton, L., Fleming, H., Cobb, B., Merkenschlager, M., et al. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0913574107 · Cited by 348 · see citing works

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

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Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis

Yuan, J., Nguyen, C. K., Liu, X., Kanellopoulou, C., & Muljo, S. A. (2012) · Science · doi:10.1126/science.1216557 · Cited by 343 · see citing works

Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites

Moss, E. G., & Tang, L. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00126-x · Cited by 329 · see citing works

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Zhu, H., Shah, S. P., Shyh‐Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., et al. (2010) · Nature Genetics · doi:10.1038/ng.593 · Cited by 306 · see citing works

Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs

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Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma

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MicroRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets

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MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

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Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiencyPreprint

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Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans

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LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance

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Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines

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Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma

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MicroRNA miR-125b causes leukemia

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Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

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Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

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Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1

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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

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IGF-II is regulated by microRNA-125b in skeletal myogenesis

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LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

Lehrbach, N. J., Armisen, J., Lightfoot, H. L., Murfitt, K. J., Bugaut, A., Balasubramanian, S., & Miska, E. A. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1675 · Cited by 230 · see citing works

daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans

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Tumor-Initiating Cells Are Rare in Many Human Tumors

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LIN28B Promotes Colon Cancer Progression and Metastasis

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LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells

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The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse

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miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemiaPreprint

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Telomere length is reset during early mammalian embryogenesis

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MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets

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Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosisPreprint

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Identification of Let-7–Regulated Oncofetal Genes

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Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7)

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Localization of the Developmental Timing Regulator Lin28 to mRNP Complexes, P-bodies and Stress Granules

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Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells

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Genome-Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells

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The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter

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Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment

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LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

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Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse

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Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia

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Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

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Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition

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Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression

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Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs

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Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis

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Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

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A Late Transition in Somatic Cell Reprogramming Requires Regulators Distinct from the Pluripotency Network

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A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans

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A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency

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Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation

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MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit

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Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A

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LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans

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Changes in Hypothalamic Expression of the Lin28/let-7 System and Related MicroRNAs During Postnatal Maturation and After Experimental Manipulations of Puberty

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let-7 Overexpression Leads to an Increased Fraction of Cells in G2/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts

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Presence of telomeric G‐strand tails in the telomerase catalytic subunit TERT knockout mice

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Therapeutic Targeting of Myc-Reprogrammed Cancer Cell MetabolismPreprint

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Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function

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Functional Variants of the HMGA1 Gene and Type 2 Diabetes Mellitus

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A genome-wide approach reveals novel imprinted genes expressed in the human placenta

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Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes

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Glucose regulation and oxidative stress in healthy centenarians

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Musashi1 Cooperates in Abnormal Cell Lineage Protein 28 (Lin28)-mediated Let-7 Family MicroRNA Biogenesis in Early Neural Differentiation

Kawahara, H., Okada, Y., Imai, T., Iwanami, A., Mischel, P. S., & Okano, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199166 · Cited by 81 · see citing works

lin-28 Controls the Succession of Cell Fate Choices via Two Distinct Activities

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Lin-28 Homologue A (LIN28A) Promotes Cell Cycle Progression via Regulation of Cyclin-dependent Kinase 2 (CDK2), Cyclin D1 (CCND1), and Cell Division Cycle 25 Homolog A (CDC25A) Expression in Cancer

Li, N., Zhong, X., Lin, X., Guo, J., Zou, L., Tanyi, J. L., Shao, Z., Liang, S., Wang, L., Hwang, W., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.321158 · Cited by 75 · see citing works

Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma

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RNA-binding protein LIN28 is a marker for testicular germ cell tumors

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Healthy Aging: Is Smaller Better? – A Mini-Review

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Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin‐28 in Caenorhabditis elegans

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Targeted killing of a mammalian cell based upon its specialized metabolic state

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Sox2 Uses Multiple Domains to Associate with Proteins Present in Sox2-Protein Complexes

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Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development

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RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases

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Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma

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Lin28a Regulates Germ Cell Pool Size and Fertility

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RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours

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Human pluripotent stem cells decouple respiration from energy production

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Leucine-Rich Repeat Kinase 2 Modulates Retinoic Acid-Induced Neuronal Differentiation of Murine Embryonic Stem Cells

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The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

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Age-dependent effects of <i>Igf2bp2</i> on gene regulation, function, and aging of hematopoietic stem cells in mice

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The Hippo signal transduction network for exercise physiologists

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PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway

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Dead Cas(t) light on new life: CRISPRa-mediated reprogramming of somatic cells into neurons

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The Progress of Epigenetics in Somatic Nuclear Reprogramming

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Five classic articles in somatic cell reprogramming.

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Two Effective Routes for Removing Lineage Restriction Roadblocks: From Somatic Cells to Hepatocytes

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