The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity
Open accessAbstract
SUMMARY We have assembled, annotated, and analyzed a database of over 1700 breakpoints from the most common chromosomal rearrangements in human leukemias and lymphomas. Using this database, we show that although the CpG dinucleotide constitutes only 1% of the human genome, it accounts for 40–70% of breakpoints at proB/pre-B stage translocation regions – specifically, those near the bcl-2, bcl-1, and E2A genes. We do not observe CpG hotspots in rearrangements involving lymphoid-myeloid progenitors, mature B cells, or T cells. The stage-specificity, lineage-specificity, CpG targeting, and unique breakpoint distributions at these cluster regions may be explained by a lesion-specific double-strand breakage mechanism involving the RAG complex acting at AID-deaminated methyl-CpGs.
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The essentials of DNA methylation
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Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882
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Schatz, D. G., & Ji, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2941 · Cited by 658
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Metadata
- Authors
- Tsai, A. G., Lu, H., Raghavan, S. C., Muschen, M., Hsieh, C.-L., & Lieber, M. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 135
- Issue
- 6
- Pages
- 1130-1142
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2056265881
- Cited by
- 238
- References
- 4
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tsai, A. G., Lu, H., Raghavan, S. C., Muschen, M., Hsieh, C.-L., & Lieber, M. R. (2008). Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity. Cell. https://doi.org/10.1016/j.cell.2008.10.035
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