The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling
Open accessAbstract
SUMMARY The Disrupted In Schizophrenia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scottish family with a high incidence of major depression, schizophrenia and bipolar disorder. Subsequent studies provided indications that DISC1 plays a role in brain development. Here we demonstrate that suppression of DISC1 expression reduces neural progenitor proliferation, leading to premature cell cycle exit and differentiation. Several lines of evidence suggest that DISC1 mediates this function by regulating GSK3β. First, DISC1 inhibits GSK3β activity through direct physical interaction, which reduces β-catenin phosphorylation and stabilizes β-catenin. Importantly, expression of stabilized β-catenin overrides the impairment of progenitor proliferation caused by DISC1 loss-of-function. Furthermore, GSK3 inhibitors normalize progenitor proliferation and behavioral defects caused by DISC1 loss-of-function. Together, these results implicate DISC1 in GSK3β/β-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders.
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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
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The physiology, signaling, and pharmacology of dopamine receptors
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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
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Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
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The Diagnosis of Mental Disorders: The Problem of Reification
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Metadata
- Authors
- Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., Tassa, C., Berry, E. M., Soda, T., Singh, K. K., Biechele, T., Petryshen, T. L., Moon, R. T., Haggarty, S. J., & Tsai, L.-H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 136
- Issue
- 6
- Pages
- 1017-1031
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2153779995
- Cited by
- 774
- References
- 53
- FWCI
- 50.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., Tassa, C., Berry, E. M., Soda, T., Singh, K. K., Biechele, T., Petryshen, T. L., Moon, R. T., Haggarty, S. J., & Tsai, L.-H. (2009). Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling. Cell. https://doi.org/10.1016/j.cell.2008.12.044
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