Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Open accessAbstract
The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.
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They did not find clusters strongly related to adult neurogenesis in DG.
“We did not find clusters strongly related to adult neurogenesis in DG (Goncalves et al., 2016)”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Goncalves et al., 2016
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“First, proliferating progenitor cells are generated in the hippocampal subgranular zone and differentiate into dentate granule neurons (23).”
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- Authors
- Gonçalves, J. T., Schafer, S. T., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Gage, Fred H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 167
- Issue
- 4
- Pages
- 897-914
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2547225283
- Cited by
- 1,122
- References
- 132
- Citations by year
- 2026: 74 · 2025: 101 · 2024: 101 · 2023: 107 · 2022: 126 · 2021: 134 · 2020: 150 · 2019: 113 · 2018: 132 · 2017: 81 · 2016: 3
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, hippocampus, dentate gyrus, neural stem cells, adult-born neurons, neural integration, neuroplasticity, learning and memory, behavior
- MeSH terms
- Animals, Mental Disorders, Hippocampus, Humans, Neurodegenerative Diseases, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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