Cited by 1,122Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

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Gonçalves, J. Tiago, Schafer, Simon T., Gage, Fred H.·2016·Cell

Abstract

The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.

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Crossref · 10.1016/j.cell.2016.10.021

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132 of 132 references verified0 citation errors · 0 not checkable

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Authors
Gonçalves, J. T., Schafer, S. T., & Gage, F. H.
Affiliations
Salk Institute for Biological Studies (US)
Corresponding author
Gage, Fred H.
Venue
Cell
Publisher
Elsevier BV
Published
2016-11
Volume
167
Issue
4
Pages
897-914
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2547225283
Cited by
1,122
References
132
Citations by year
2026: 74 · 2025: 101 · 2024: 101 · 2023: 107 · 2022: 126 · 2021: 134 · 2020: 150 · 2019: 113 · 2018: 132 · 2017: 81 · 2016: 3
FWCI
13.64
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult neurogenesis, hippocampus, dentate gyrus, neural stem cells, adult-born neurons, neural integration, neuroplasticity, learning and memory, behavior
MeSH terms
Animals, Mental Disorders, Hippocampus, Humans, Neurodegenerative Diseases, Adult Stem Cells, Neurogenesis, Neural Stem Cells

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