The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation
Open accessAbstract
Summary The C. elegans insulin/IGF-1 signaling (IIS) cascade plays a central role in the regulation of lifespan, dauer diapause, metabolism and stress response. The major regulatory control of IIS is through phosphorylation of its components by serine/threonine-specific protein kinases. In a RNAi screen for serine/threonine protein phosphatases that counter-balance the effect of the kinases in the IIS pathway, we identified pptr-1, a B56 regulatory subunit of the PP2A holoenzyme. Modulation of pptr-1 affects phenotypes associated with the IIS pathway including lifespan, dauer, stress resistance and fat storage. We show that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr 350. With striking conservation, mammalian B56β regulates Akt phosphorylation at Thr 308 in 3T3-L1 adipocytes. In C. elegans, this modulation ultimately leads to changes in subcellular localization and transcriptional activity of the forkhead transcription factor DAF-16. This study reveals a conserved role for the B56 regulatory subunit in modulating insulin signaling through AKT dephosphorylation and thereby has widespread implications in cancer and diabetes research.
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AKT/PKB Signaling: Navigating the Network
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Insulin/insulin-like growth factor signaling in C. elegans
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Metadata
- Authors
- Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G., Czech, M. P., & Tissenbaum, H. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 136
- Issue
- 5
- Pages
- 939-951
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2060964204
- Cited by
- 170
- References
- 9
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G., Czech, M. P., & Tissenbaum, H. A. (2009). A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation. Cell. https://doi.org/10.1016/j.cell.2009.01.025
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