Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
Open accessAbstract
Using an siRNA-based screen, we identified the transcriptional corepressor RIP140 as a negative regulator of insulin-responsive hexose uptake and oxidative metabolism in 3T3-L1 adipocytes. Affymetrix GeneChip profiling revealed that RIP140 depletion upregulates the expression of clusters of genes in the pathways of glucose uptake, glycolysis, TCA cycle, fatty acid oxidation, mitochondrial biogenesis, and oxidative phosphorylation in these cells. Conversely, we show that reexpression of RIP140 in mouse embryonic fibroblasts derived from RIP140-null mice downregulates expression of many of these same genes. Consistent with these microarray data, RIP140 gene silencing in cultured adipocytes increased both conversion of [14C]glucose to CO2 and mitochondrial oxygen consumption. RIP140-null mice, previously reported to resist weight gain on a high-fat diet, are shown here to display enhanced glucose tolerance and enhanced responsiveness to insulin compared with matched wild-type mice upon high-fat feeding. Mechanistically, RIP140 was found to require the nuclear receptor ERRalpha to regulate hexose uptake and mitochondrial proteins SDHB and CoxVb, although it likely acts through other nuclear receptors as well. We conclude that RIP140 is a major suppressor of adipocyte oxidative metabolism and mitochondrial biogenesis, as well as a negative regulator of whole-body glucose tolerance and energy expenditure in mice.
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Nuclear co-repressor RIP140 directs histone and DNA methylation to silence UCP1 expression and suppress mitochondrial biogenesis in white adipocytes.
“Nuclear co-repressor RIP140 directs histone and DNA methylation to silence UCP1 expression and suppress mitochondrial biogenesis in white adipocytes 169,170.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [170]
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Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
Diatchenko, L. B., Lau, Y. C., Campbell, A. P., Chenchik, A. A., Moqadam, F., Huang, B. C. B., Lukyanov, S., Lukyanov, K. A., Gurskaya, N. G., Sverdlov, E. D., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6025 · Cited by 3,009 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889 · see citing works
PPARs and the complex journey to obesity
Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works
Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
Ntambi, J. M., Miyazaki, M., Stoehr, J. P., Hong, L., Kendziorski, C. M., Yandell, B. S., Song, Y., Cohen, P., Friedman, J. M., & Attie, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132384699 · Cited by 1,096 · see citing works
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
Cavaillès, V., Dauvois, S., L’Horset, F., Lopez, G. N., Hoare, S., Kushner, P. J., & Parker, M. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00044.x · Cited by 740 · see citing works
Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St. Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401401101 · Cited by 688 · see citing works
Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675 · see citing works
Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Wisløff, U., Najjar, S. M., Ellingsen, Ø., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G., et al. (2005) · Science · doi:10.1126/science.1108177 · Cited by 657 · see citing works
Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP
Lin, J. D., Yang, R., Tarr, P. T., Wu, P., Handschin, C., Li, S., Yang, W., Pei, L., Uldry, M., Tontonoz, P., et al. (2005) · Cell · doi:10.1016/j.cell.2004.11.043 · Cited by 618 · see citing works
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works
Lin, J., Puigserver, P., Donovan, J., Tarr, P., & Spiegelman, B. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100631200 · Cited by 552 · see citing works
Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 520 · see citing works
Signaling Mechanisms That Regulate Glucose Transport
Czech, M., & Corvera, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.1865 · Cited by 514 · see citing works
Huss, J. M., Pineda‐Torra, I., Staels, B., Giguère, V., & Kelly, D. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9079-9091.2004 · Cited by 485 · see citing works
Acquirement of brown fat cell features by human white adipocytes
Tiraby, C., Tavernier, G., Lefort, C., Larrouy, D., Bouillaud, F., Ricquier, D., & Langin, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305235200 · Cited by 474 · see citing works
Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459 · see citing works
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
Picard, F., Géhin, M., Annicotte, J., Rocchi, S., Champy, M., O’Malley, B. W., Chambon, P., & Auwerx, J. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01169-8 · Cited by 444 · see citing works
The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones
Arner, P. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00024-9 · Cited by 423 · see citing works
Jiang, Z. Y., Zhou, Q. L., Coleman, K. A., Chouinard, M., Boese, Q., & Czech, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332633100 · Cited by 378 · see citing works
Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.
Luo, J., Sladek, R., Carrier, J., Bader, J.-A., Richard, D., & Giguère, V. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7947-7956.2003 · Cited by 370 · see citing works
Distinct Transcriptional Profiles of Adipogenesisin Vivo and in Vitro
Soukas, A. A., Socci, N. D., Saatkamp, B. D., Novelli, S. E., & Friedman, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104421200 · Cited by 368 · see citing works
Nuclear receptor corepressor RIP140 regulates fat accumulation
Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366 · see citing works
Kamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O., & Kakizuka, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135217100 · Cited by 357 · see citing works
Tamori, Y., Masugi, J., Nishino, N., & Kasuga, M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2045 · Cited by 294 · see citing works
Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle
Ojuka, E., Jones, T. E., Han, D.-H., Chen, M. M., & Holloszy, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0951com · Cited by 258 · see citing works
A Regulatory Role for RIP140 in Nuclear Receptor Activation
Treuter, E., Albrektsen, T., Johansson, L., Leers, J., & Gustafsson, J.-Α. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.6.0123 · Cited by 229 · see citing works
Regulation of Mitochondrial Biogenesis by Thyroid Hormone
Weitzel, J. M., Iwen, K. A., & Seitz, H. J. (2003) · Experimental Physiology · doi:10.1113/eph8802506 · Cited by 223 · see citing works
Minokoshi, Y., Kahn, C. R., & Kahn, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300019200 · Cited by 219 · see citing works
Meirhaeghe, A., Crowley, V., Lenaghan, C., Lelliott, C. J., GREEN, K., Stewart, A., Kevin, H. A. R. T., Schinner, S., Sethi, J. K., Yeo, G. S. H., et al. (2003) · Biochemical Journal · doi:10.1042/bj20030200 · Cited by 210 · see citing works
Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression
Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409189200 · Cited by 206 · see citing works
The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility
White, R., Leonardsson, G., Rosewell, I. R., Jacobs, M. A., Milligan, S. R., & Parker, M. G. (2000) · Nature Medicine · doi:10.1038/82183 · Cited by 193 · see citing works
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2002) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2002.120111_3.x · Cited by 188 · see citing works
RIP140-Targeted Repression of Gene Expression in Adipocytes
Christian, M., Kiskinis, E., Debevec, D., Leonardsson, G., White, R., & Parker, M. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9383-9391.2005 · Cited by 181 · see citing works
Higami, Y., Pugh, T. D., Page, G. P., Allison, D. B., Prolla, T. A., & Weindruch, R. (2004) · The FASEB Journal · doi:10.1096/fj.03-0678fje · Cited by 173 · see citing works
Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice
Oh, W. K., Abu-Elheiga, L. A., Kordari, P., Gu, Z.-W., Shaiken, T. E., Chirala, S. S., & Wakil, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409451102 · Cited by 139 · see citing works
Mukherjee, R., Hoener, P. A., Jow, L., Bilakovics, J. M., Klausing, K., Mais, D. E., Faulkner, A. L., Croston, G. E., & Paterniti, J. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.9.0528 · Cited by 132 · see citing works
Peroxisome proliferator‐activated receptor‐γ: too much of a good thing causes harm
Cock, T., Houten, S. M., & Auwerx, J. H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400082 · Cited by 131 · see citing works
RIP-140 Interacts with Multiple Nuclear Receptors by Means of Two Distinct Sites
L’Horset, F., Dauvois, S., Heery, D. M., Cavaillès, V., & Parker, M. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6029 · Cited by 129 · see citing works
PPARs and the complex journey to obesity
Evans, R. M. (2004) · The Keio Journal of Medicine · doi:10.2302/kjm.53.53 · Cited by 123 · see citing works
Watson, R. T., & Pessin, J. E. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5375 · Cited by 118 · see citing works
Tang, X., Powelka, A. M., Soriano, N. A., Czech, M., & Guilherme, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501949200 · Cited by 103 · see citing works
Self-citationNugent, C., Prins, J. B., Whitehead, J. P., Savage, D. B., Wentworth, J. M., Chatterjee, K., & O’Rahilly, S. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0715 · Cited by 93 · see citing works
Deveaud, C., Beauvoit, B., Salin, B., Schaeffer, J., & Rigoulet, M. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049374.52989.9b · Cited by 88 · see citing works
Eriksson, K., & Lindg�rde, F. (1990) · Diabetologia · doi:10.1007/bf00404139 · Cited by 86 · see citing works
Kanoh, Y., Bandyopadhyay, G. K., Sajan, M. P., Standaert, M. L., & Farese, R. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000287200 · Cited by 68 · see citing works
Park, S. Y., Choi, G. H., Choi, H. I., Ryu, J., Jung, C. Y., & Lee, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409399200 · Cited by 61 · see citing works
Comparison of adipose tissue changes following administration of rosiglitazone in the dog and rat
Toseland, C. D. N., Campbell, S., Francis, I., Bugelski, P. J., & Mehdi, N. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00117.x · Cited by 43 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Schreiber, S.N., et al. 2004. The estrogen-related receptor alpha (ERRalpha) functions in PPARgam- ma coactivator 1alpha (PGC-1alpha)-induced mito- chondrial biogenesis. Proc. Natl. Acad. Sci. U. S. A. 101:6472-6477.
Cited by
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Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508 · see citing works
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281 · see citing works
Transcriptional Control of Brown Fat Determination by PRDM16
Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works
Adaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828 · see citing works
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development · doi:10.1101/gad.1666108 · Cited by 468 · see citing works
Joseph, A., Adhihetty, P. J., Buford, T. W., Wohlgemuth, S. E., Lees, H. A., Nguyen, L. M. ‐., Aranda, J. M., Sandesara, B. D., Pahor, M., Manini, T. M., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00844.x · Cited by 395 · see citing works
Pharmacological approaches to restore mitochondrial function
Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383 · see citing works
Mitochondrial biogenesis and healthy aging
López-Lluch, G., Irusta, P. M., Navas, P., & de Cabo, R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.014 · Cited by 364 · see citing works
Repairing mitochondrial dysfunction in disease
Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104908 · Cited by 337 · see citing works
Rong, J. X., Qiu, Y., Hansen, M. K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Mattie, M. D., Higashiyama, H., Asano, S., et al. (2007) · Diabetes · doi:10.2337/db06-1135 · Cited by 335 · see citing works
Transcriptional coregulators in the control of energy homeostasis
Feige, J. N., & Auwerx, J. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.04.001 · Cited by 325 · see citing works
Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301 · see citing works
ERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · see citing works
“First, ERRα can act as a downstream effector of the corepressor RIP140 [40,54].”
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Douris, N., Stevanovic, D. M., Fisher, F. M., Cisu, T. I., Chee, M. J., Nguyen, N. L., Zarebidaki, E., Adams, A. C., Kharitonenkov, A., Flier, J. S., et al. (2015) · Endocrinology · doi:10.1210/en.2014-2001 · Cited by 215 · see citing works
Regulatory circuits controlling white versus brown adipocyte differentiation
Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178 · see citing works
Molecular determinants of brown adipocyte formation and function: Figure 1.
Farmer, S. R. (2008) · Genes & Development · doi:10.1101/gad.1681308 · Cited by 165 · see citing works
Diabetes regulates mitochondrial biogenesis and fission in mouse neurons
Edwards, J. L., Quattrini, A., Lentz, S. I., Figueroa-Romero, C., Cerri, F., Backus, C., Hong, Y., & Feldman, E. L. (2010) · Diabetologia · doi:10.1007/s00125-009-1553-y · Cited by 156 · see citing works
Yuan, R., Meng, Q., Nautiyal, J., Flurkey, K., Tsaih, S.-W., Krier, R., Parker, M. G., Harrison, D. E., & Paigen, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121113109 · Cited by 121 · see citing works
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
Kiskinis, E., Hallberg, M., Christian, M., Olofsson, M., Dilworth, S. M., White, R., & Parker, M. G. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601908 · Cited by 111 · see citing works
Okamoto, Y., Higashiyama, H., Rong, J. X., McVey, M. J., Kinoshita, M., Asano, S., & Hansen, M. K. (2007) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2007.02.007 · Cited by 38 · see citing works
- Authors
- Powelka, A. M.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Powelka, A. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-12-08
- Volume
- 116
- Issue
- 1
- Pages
- 125-136
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1319222
- OpenAlex
- W2128973774
- Cited by
- 236
- References
- 59
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 22
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- Wellcome Trust (061930)
- Imperial College London
- China Scholarship Council
- National Institutes of Health (DK30898)
- U.S. Public Health Service (D32520-20)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK030898, R37DK030898, DK30898, DK60837-03, R01DK060837)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- RIP140, corepressors, adipocytes, oxidative metabolism, mitochondrial biogenesis, glucose uptake, insulin sensitivity, glucose tolerance, estrogen-related receptor alpha, nuclear receptors, SDHB, high-fat diet, energy expenditure, 3T3-L1 adipocytes, fatty acid oxidation
- MeSH terms
- Nuclear Receptor Interacting Protein 1, Animals, Citric Acid Cycle, Energy Metabolism, Glucose, Glycolysis, Mitochondria, Nuclear Proteins, Oxidative Phosphorylation, Repressor Proteins, 3T3 Cells, Adipocytes, Adaptor Proteins, Signal Transducing, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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