The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior
Open accessAbstract
Summary The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits. These excitatory, non-selective cationic channels are regulated by G protein, phospholipase C-coupled receptors. Here, we show that TRPC5−/− mice exhibit diminished innate fear levels in response to innately aversive stimuli. Moreover, mutant mice exhibited significant reductions in responses mediated by synaptic activation of Group I metabotropic glutamate and cholecystokinin 2 receptors in neurons of the amygdala. Synaptic strength at afferent inputs to the amygdala was diminished in P10–P13 null mice. In contrast, baseline synaptic transmission, membrane excitability, and spike timing-dependent long-term potentiation at cortical and thalamic inputs to the amygdala were largely normal in older null mice. These experiments provide genetic evidence that TRPC5, activated via G protein-coupled neuronal receptors, has an essential function in innate fear.
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Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Self-citationNeuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Fear conditioning induces associative long-term potentiation in the amygdala
Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · cited 2×
“Long-term potentiation (LTP) in CS pathways may contribute to the acquisition of fear memory in response to auditory stimulation (Rogan et al., 1997; Tsvetkov et al., 2002).”
BackgroundPitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841 · cited 5×
“…and cortico-amygdala and thalamo-amygdala EPSPs, mediated by Group I mGluRs, were significantly diminished in slices from TRPC5 / mice, while basal synaptic transmission in cortical and thalamic inputs to the LA and inputs from the LA to intercalated cells (Pare et al., 2004) was unaltered.”
BackgroundInfluentialFear conditioning induces a lasting potentiation of synaptic currents in vitro
McKernan, M. G., & Shinnick-Gallagher, P. (1997) · Nature · doi:10.1038/37605 · Cited by 771
The Neuroscience of Mammalian Associative Learning
Fanselow, M. S., & Poulos, A. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070213 · Cited by 683
Cited by
Advances in TRP channel drug discovery: from target validation to clinical studies
Koivisto, A.-P., Belvisi, M. G., Gaudet, R., & Szallasi, A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00268-4 · Cited by 537
Rheotaxis Guides Mammalian Sperm
Miki, K., & Clapham, D. E. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.007 · Cited by 444
Self-citationTransient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
He, Z., Gao, Y., Lieu, L., Afrin, S., Cao, J., Michael, N. J., Dong, Y., Sun, J., Guo, H., & Williams, K. W. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.07.008 · Cited by 128
Dong, Y., Carty, J., Goldstein, N., He, Z., Hwang, E., Chau, D., Wallace, B., Kabahizi, A., Lieu, L., Peng, Y., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101352 · Cited by 93
Metadata
- Authors
- Riccio, A., Li, Y., Moon, J., Kim, K.-S., Smith, K. S., Rudolph, U., Gapon, S., Yao, G. L., Tsvetkov, E., Rodig, S. J., Van't Veer, A., Meloni, E. G., Carlezon, W. A., Bolshakov, V. Y., & Clapham, D. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 137
- Issue
- 4
- Pages
- 761-772
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2168728782
- Cited by
- 281
- References
- 13
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Riccio, A., Li, Y., Moon, J., Kim, K.-S., Smith, K. S., Rudolph, U., Gapon, S., Yao, G. L., Tsvetkov, E., Rodig, S. J., Van't Veer, A., Meloni, E. G., Carlezon, W. A., Bolshakov, V. Y., & Clapham, D. E. (2009). Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior. Cell. https://doi.org/10.1016/j.cell.2009.03.039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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