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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

Kwon, Hyock Joo, Abi-Mosleh, Lina, Wang, Michael L., Deisenhofer, Johann, Goldstein, Joseph L., Brown, Michael S., Infante, Rodney E.·2009·Cell
DOI 10.1016/j.cell.2009.03.049PMC PMC2739658
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Crossref · 10.1016/j.cell.2009.03.049

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  • NPC1 acts to enrich cholesterol in the lysosomal membrane.

    “Molecular studies have established that NPC1 acts to enrich cholesterol in the lysosomal membrane (40, 41)”

    From Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake (2023) · cites this paper as [40]

    The paper’s Abstract proposes that transfer from NPC2 to NPC1 allows cholesterol to insert into the lysosomal membrane. The Discussion says this membrane-insertion model remains unproven; it does not establish that NPC1 enriches cholesterol in that membrane. (LLM, conf=0.86)

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Research works printed but not linked: 39

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Metadata

Authors
Kwon, H. J., Abi-Mosleh, L., Wang, M. L., Deisenhofer, J., Goldstein, J. L., Brown, M. S., & Infante, R. E.
Venue
Cell
Publisher
Elsevier BV
Published
2009-06
Volume
137
Issue
7
Pages
1213-1224
ISSN
0092-8674
DOI
10.1016/j.cell.2009.03.049
PMC
PMC2739658
Cited by
636
References
3
Language
en
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